Reproducibility of endometrial intraepithelial neoplasia diagnosis is good, but influenced by the diagnostic style of pathologists

Modern Pathology

Volumn 25, Issue 6, 2012, Pages 877-884

  Usubutun, Alp ^a   Mutter, George L ^b   Saglam, Arzu ^a   Dolgun, Anil ^a   Ozkan, Eylem Akar ^c   Ince, Tan ^d   Akyol, Aytekin ^a   Bulbul, H Dilek ^e   Calay, Zerrin ^f   Eren, Funda ^g   Gumurdulu, Derya ^h   Haberal, A Nihan ^c   Ilvan, Sennur ^f   Karaveli, Seyda ⁱ   Koyuncuoglu, Meral ^j   Muezzinoglu, Bahar ^k   Muftuoglu, Kamil H ^e   Ozdemir, Necmettin ^l   Ozen, Ozlem ^c   Baykara, Sema ^m   Pestereli, Elif ⁱ   Ulukus, Emine Cagnur ^j   Zekioglu, Osman ^l   more..

^a HACETTEPE UNIVERSITY   (Turkey)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c BASKENT UNIVERSITY   (Turkey)

^d UNIVERSITY OF MIAMI   (United States)

^e Etlik Zubeyde Hanim Women's Health Teaching and Research Hospital   (Turkey)

^f ISTANBUL UNIVERSITY CERRAHPASA   (Turkey)

^g MARMARA UNIVERSITY   (Turkey)

^h CUKUROVA UNIVERSITY   (Turkey)

ⁱ AKDENIZ UNIVERSITY   (Turkey)

^j DOKUZ EYLUL UNIVERSITY   (Turkey)

^k KOCAELI UNIVERSITY   (Turkey)

^l EGE UNIVERSITY   (Turkey)

^m ULUDAG UNIVERSITY   (Turkey)

more..

Author keywords

endometrial hyperplasia; endometrial intraepithelial neoplasia; reproducibility

Indexed keywords

ARTICLE; CANCER DIAGNOSIS; CLINICAL ARTICLE; CONSENSUS; DEMOGRAPHY; DIAGNOSTIC ACCURACY; ENDOMETRIAL INTRAEPITHELIAL NEOPLASIA; ENDOMETRIUM BIOPSY; ENDOMETRIUM CANCER; ENDOMETRIUM CARCINOMA; ENDOMETRIUM POLYP; HUMAN; INTERRATER RELIABILITY; PRIORITY JOURNAL; PROFESSIONAL PRACTICE; REPRODUCIBILITY;

ADENOCARCINOMA; BIOPSY; CARCINOMA IN SITU; CLUSTER ANALYSIS; ENDOMETRIAL NEOPLASMS; FEMALE; GUIDELINE ADHERENCE; HUMANS; OBSERVER VARIATION; PATHOLOGY, CLINICAL; PRACTICE GUIDELINES AS TOPIC; PREDICTIVE VALUE OF TESTS; QUALITY INDICATORS, HEALTH CARE; REPRODUCIBILITY OF RESULTS; TERMINOLOGY AS TOPIC; TURKEY; UNITED STATES; WORKPLACE;

EID: 84861847901     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.2011.220     Document Type: Article

References (27)

1. Bergeron C, Nogales FF, Masseroli M, et al. A multicentric European study testing the reproducibility of the WHO classification of endometrial hyperplasia with a proposal of a simplified working classification for biopsy and curettage specimens. Am J Surg Pathol 1999;23:1102-1108. (Pubitemid 29409773)
2. Kendall BS, Ronnett BM, Isacson C, et al. Reproducibility of the diagnosis of endometrial hyperplasia, atypical hyperplasia, and well-differentiated carcinoma. Am J Surg Pathol 1998;22:1012-1019. (Pubitemid 28364502)
3. Dietel M. The histological diagnosis of endometrial hyperplasia - Is there a need to simplify? Virchows Arch 2001;439:604-608. (Pubitemid 33071196)
4. Zaino RJ. Endometrial hyperplasia: is it time for a quantum leap to a new classification? Int J Gynecol Pathol 2000;19:314-321.
5. Skov BG, Broholm H, Engel U, et al. Comparison of the reproducibility of the WHO classifications of 1975 and 1994 of endometrial hyperplasia. Int J Gynecol Pathol 1997;16:33-37. (Pubitemid 27199583)
6. Kurman RJ, Kaminski PF, Norris HJ. The behavior of endometrial hyperplasia - a long-term study of untreated hyperplasia in 170 patients. Cancer 1985;56: 403-412. (Pubitemid 15031667)
7. Mutter GL. Endometrial intraepithelial neoplasia (EIN): Will it bring order to chaos? Gynecol Oncol 2000;76:287-290. (Pubitemid 30131494)
8. Mutter GL, Zaino RJ, Baak JPA, et al. Benign endometrial hyperplasia sequence and endometrial intraepithelial neoplasia. Int J Gynecol Pathol 2007;26: 103-114. (Pubitemid 46573204)
9. Mutter GL, Baak JPA, Crum CP, et al. Endometrial precancer diagnosis by histopathology, clonal analysis, and computerized morphometry. J Pathol 2000;190: 462-469. (Pubitemid 30163587)
10. Berman JJ, Albores-Saavedra J, Bostwick D, et al. Precancer: A conceptual working definition results of a consensus conference. Cancer Detect Prev 2006; 30:387-394. (Pubitemid 44750409)
11. Mutter GL, Boynton KA, Faquin WC, et al. Allelotype mapping of unstable microsatellites establishes direct lineage continuity between endometrial precancers and cancer. Cancer Res 1996;56:4483-4486. (Pubitemid 26330458)
12. Mutter GL, Chaponot ML, Fletcher JA. A polymerase chain-reaction assay for nonrandom x-chromosome inactivation identifies monoclonal endometrial cancers and precancers. Am J Pathol 1995;146:501-508.
13. Hecht JL, Mutter GL. Molecular and pathologic aspects of endometrial carcinogenesis. J Clin Oncol 2006;24: 4783-4791. (Pubitemid 46630943)
14. Mutter GL. Histopathology of genetically defined endometrial precancers. Int J Gynecol Pathol 2000;19: 301-309.
15. Mutter GL. Diagnosis of premalignant endometrial disease. J Clin Pathol 2002;55:326-331. (Pubitemid 34494169)
16. Hecht JL, Ince TA, Baak JPA, et al. Prediction of endometrial carcinoma by subjective endometrial intraepithelial neoplasia diagnosis. Modern Pathol 2005;18:324-330. (Pubitemid 40395349)
17. Baak JP, Mutter GL, Robboy S, et al. The molecular genetics and morphometry-based Endometrial Intraepithelial Neoplasia classification system predicts disease progression in Endometrial hyperplasia more accurately than the 1994 World Health Organization classification system. Cancer 2005;103: 2304-2312. (Pubitemid 40686575)
18. Orbo A, Baak JPA, Kleivan I, et al. Computerised morphometrical analysis in endometrial hyperplasia for the prediction of cancer development. A long term retrospective study from northern Norway. J Clin Pathol 2000;53:697-703.
19. Baak JPA, Orbo A, van Diest PJ, et al. Prospective multicenter evaluation of the morphometric D-score for prediction of the outcome of endometrial hyperplasias. Am J Surg Pathol 2001;25:930-935. (Pubitemid 32594987)
20. Mutter GL, Zaino RJ, Baak JPA, et al. Benign endometrial hyperplasia and EIN, In: Robboy SJ, Mutter GL, Prat J, Bentley RC, Russel P, Anderson MC (eds). Robboy's Pathology of Female Reproductive Tract. 2nd edn. Elsevier: China, 2009, pp 367-397.
21. Fleiss JL, Levin B, Paik MC, (eds). Statistical Methods for Rates and Proportions, 3rd edn. John Wiley & Sons: New York, 2003, pp 614-617.
22. Zaino RJ, Kauderer J, Trimble CL, et al. Reproducibility of the diagnosis of atypical endometrial hyperplasia - A Gynecologic Oncology Group Study. Cancer 2006;106:804-811. (Pubitemid 43238447)
23. Landis JR, Koch GG. Measurement of Observer Agreement for Categorical Data. Biometrics 1977;33:159-174. (Pubitemid 8054849)
24. Mutter GL, Duska L, Crum CP. Endometrial intraepithelial neoplasia, In: Crum CP, Lee K (eds). Diagnostic Gynecologic and Obstetric Pathology. 1st edn. Saunders: China, 2006, pp 493-518.
25. Carlson JW, Mutter GL. Endometrial intraepithelial neoplasia is associated with polyps and frequently has metaplastic change. Histopathology 2008;53: 325-332.
26. Dunton CJ, Baak JPA, Palazzo JP, et al. Use of computerized morphometric analyses of endometrial hyperplasias in the prediction of coexistent cancer. Am J Obstet Gynecol 1996;174:1518-1521. (Pubitemid 26165271)
27. Baak JPA, Nauta JJP, Wissebrekelmans ECM, et al. Architectural and nuclear morphometrical features together are more important prognosticators in endometrial hyperplasias than nuclear morphometrical features alone. J Pathol 1988;154:335-341.