Endometrial intraepithelial neoplasia is associated with polyps and frequently has metaplastic change

Histopathology

Volumn 53, Issue 3, 2008, Pages 325-332

  Carlson, J W ^a   Mutter, G L ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Endometrial intraepithelial neoplasia; Histopathology; Metaplasia; Polyp; Precancer

Indexed keywords

ADULT; AGED; ARTICLE; DISEASE ASSOCIATION; ENDOMETRIUM BIOPSY; ENDOMETRIUM POLYP; FEMALE; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; METAPLASIA; PRIORITY JOURNAL; UTERINE CERVIX CARCINOMA IN SITU;

ADULT; AGED; AGED, 80 AND OVER; CELL DIFFERENTIATION; ENDOMETRIAL NEOPLASMS; EPITHELIAL CELLS; FEMALE; HUMANS; METAPLASIA; MIDDLE AGED; POLYPS; YOUNG ADULT;

EID: 50049127811     PISSN: 03090167     EISSN: 13652559     Source Type: Journal    
DOI: 10.1111/j.1365-2559.2008.03104.x     Document Type: Article

References (28)

1. Mutter GL, Zaino RJ, Baak JPA, Bentley RC, Robboy SJ. The benign endometrial hyperplasia sequence and endometrial intraepithelial neoplasia. Int. J. Gynecol. Pathol. 2007 26 103 114.
2. Mutter GL, Baak JPA, Crum CP, Richart RM, Ferenczy A, Faquin WC. Endometrial precancer diagnosis by histopathology, clonal analysis, and computerized morphometry. J. Pathol. 2000 190 462 469.
3. Mutter GL, Boynton KA, Faquin WC, Ruiz RE, Jovanovic AS. Allelotype mapping of unstable microsatellites establishes direct lineage continuity between endometrial precancers and cancer. Cancer Res. 1996 56 4483 4486.
4. Jovanovic AS, Boynton KA, Mutter GL. Uteri of women with endometrial carcinoma contain a histopathologic spectrum of monoclonal putative precancers, some with microsatellite instability. Cancer Res. 1996 56 1917 1921.
5. Mutter GL, Duska L, Crum CP. Endometrial intraepithelial neoplasia. In Crum CP, Lee K eds. Diagnostic gynecologic and obstetric pathology, 1st edn. Philadelphia, PA : Saunders, 2005 493 518.
6. Berman JJ, Bores-Saavedra J, Bostwick D et al. Precancer: a conceptual working definition. Results of a Consensus Conference. Cancer Detect. Prev. 2006 30 387 394.
7. Mutter GL. Diagnosis of premalignant endometrial disease. J. Clin. Pathol. 2002 55 326 331.
8. Silverberg SG, Mutter GL, Kurman RJ, Kubik-Huch RA, Nogales F, Tavassoli FA. Tumors of the uterine corpus: epithelial tumors and related lesions. In Tavassoli FA, Stratton MR eds. WHO classification of tumors: pathology and genetics of tumors of the breast and female genital organs, 1st edn. Lyon, France : IARC Press, 2003 221 232.
9. Baak JP, Mutter GL, Robboy S et al. The molecular genetics and morphometry-based endometrial intraepithelial neoplasia classification system predicts disease progression in endometrial hyperplasia more accurately than the 1994 World Health Organization classification system. Cancer 2005 103 2304 2312.
10. Hecht JL, Mutter GL. Molecular and pathologic aspects of endometrial carcinogenesis. J. Clin. Oncol. 2006 24 4783 4791.
11. Hecht JL, Ince TA, Baak JPA et al. Prediction of endometrial carcinoma by subjective EIN diagnosis. Mod. Path. 2005 18 324 330.
12. Crum CP, Hornstein MD, Stewart EA. Evaluation of cyclic endometrium and benign endometrial disorders. In Crum CP, Lee KR eds. Diagnostic gynecologic and obstetric pathology, 1st edn. Philadelphia, PA : Elsevier Saunders, 2006 441 491.
13. Mutter GL, Kauderer J, Baak JPA, Alberts DA. Biopsy histomorphometry predicts uterine myoinvasion by endometrial carcinoma: a Gynecologic Oncology Group Study. Hum. Pathol. 2008 39 866 874.
14. Fletcher J, Pinkus J, Lage J, Morton C, Pinkus G. Clonal 6p21 rearrangement is restricted to the mesenchymal component of an endometrial polyp. Genes Chromosomes Cancer 1992 5 260 263.
15. Dal Cin P, Vanni R, Marras S et al. Four cytogenetic subgroups can be identified in endometrial polyps. Cancer Res. 1995 55 1565 1568.
16. Peterson W, Novak E. Endometrial polyps. Obstet. Gynecol. 1956 8 40 49.
17. Gray L, Robertson R, Christopherson W. Atypical endometrial changes associated with carcinoma. Gynecol. Oncol. 1974 2 93 100.
18. Hertig A, Sommers S. Genesis of endometrial carcinoma. I. Study of prior biopsies. Cancer 1949 2 946 956.
19. Andersen WA, Taylor PT Jr., Fechner RE, Pinkerton JA. Endometrial metaplasia associated with endometrial adenocarcinoma. Am. J. Obstet. Gynecol. 1987 157 597 604.
20. Chiarelli S, Buritica C, Litta P, Ciani S, Guarch R, Nogales FF. An immunohistochemical study of morules in endometrioid lesions of the female genital tract: CD10 is a characteristic marker of morular metaplasia. Clin. Cancer Res. 2006 12 4251 4256.
21. Nucci M, Crum CP, Prasad C, Mutter GL. Mucinous endometrial epithelial proliferations: a morphologic spectrum of changes with diverse clinical significance. Mod. Pathol. 2000 12 1137 1142.
22. Kaku T, Tsukamoto N, Tsuruchi N, Sugihara K, Kamura T, Nakano H. Endometrial metaplasia associated with endometrial carcinoma. Obstet. Gynecol. 1992 80 812 816.
23. Moritani S, Kushima R, Ichihara S et al. Eosinophilic cell change of the endometrium: a possible relationship to mucinous differentiation. Mod. Pathol. 2005 18 1243 1248.
24. Hendrickson MR, Kempson RL. Endometrial epithelial metaplasias: proliferations frequently misdiagnosed as adenocarcinoma. Report of 89 cases and proposed classification. Am. J. Surg. Pathol. 1980 4 525 542.
25. Kaku T, Silverberg SG, Tsukamoto N et al. Association of endometrial epithelial metaplasias with endometrial carcinoma and hyperplasia in Japanese and American women. Am. J. Pathol. 1993 12 297 300.
26. Brachtel EF, Sanchez-Estevez C, Moreno-Bueno G, Prat J, Palacios J, Oliva E. Distinct molecular alterations in complex endometrial hyperplasia (CEH) with and without immature squamous metaplasia (squamous morules). Am. J. Surg. Pathol. 2005 29 1322 1329.
27. Saegusa M, Okayasu I. Frequent nuclear beta-catenin accumulation and associated mutations in endometrioid-type endometrial and ovarian carcinomas with squamous differentiation. J. Pathol. 2001 194 59 67.
28. Wheeler DT, Bristow RE, Kurman RJ. Histologic alterations in endometrial hyperplasia and well-differentiated carcinoma treated with progestins. Am. J. Surg. Pathol. 2007 31 988 998.