A new tandem cross metathesis-intramolecular aza-Michael reaction for the synthesis of α,α-difluorinated lactams

Synthesis (Germany)

Volumn 44, Issue 12, 2012, Pages 1863-1873

  Fustero, Santos ^a   Báez, Claribel ^a   Sánchez Roselló, María ^a   Asensio, Amparo ^a   Miro, Javier ^a   Del Pozo, Carlos ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

Author keywords

amides; asymmetric catalysis; catalysis; fluorine; heterocycles; Michael additions; tandem reactions

Indexed keywords

ASYMMETRIC CATALYSIS; AZA-MICHAEL REACTION; COCATALYST; DIFLUORINATED; HETEROCYCLES; MICHAEL ACCEPTORS; MICHAEL ADDITIONS; RUTHENIUM CATALYSTS; STEP BY STEP PROCEDURE; TANDEM REACTION; TETRAISOPROPOXIDE;

ADDITION REACTIONS; CATALYSIS; CATALYSTS; FLUORINE; KETONES; ORGANIC COMPOUNDS; RUTHENIUM; TITANIUM;

AMIDES;

2,2 DIFLUORO (4 METHOXYPHENYL)HEX 5 ENAMIDE; 2,2 DIFLUORO N (4 METHOXYPHENYL)PENT 4 ENAMIDE; 2,2 DIFLUORO N [2 (METHOXYMETHYL)PYRROLIDIN 1 YL]HEX 5 ENAMIDE; 2,2 DIFLUORO N [2 (METHOXYMETHYL)PYRROLIDIN 1 YL]PENT 4 ENAMIDE; 2,2 DIFLUORO N METHOXYHEX 5 ENAMIDE; 2,2 DIFLUORO N METHOXYPENT 4 ENAMIDE; 3,3 DIFLUORO 1 (4 METHOXYPHENYL) 5 (2 OXOPROPYL)PYYROLIDIN 2 ONE; 3,3 DIFLUORO 1 (4 METHOXYPHENYL) 6 (2 OXOPROPYL)PIPERIDIN 2 ONE; 3,3 DIFLUORO 1 [2 (METHOXYMETHYL)PYRROLIDIN 1 YL] 6 (2 OXOPROPYL)PIPERIDIN 2 ONE; 3,3 DIFLUORO 1 METHOXY 5 (2 OXOPROPYL)PYYROLIDIN 2 ONE; 3,3 DIFLUORO 1 METHOXY 6 (2 OXOPROPYL)PIPERIDIN 2 ONE; 3,3 DIFLUORO 2' (METHOXYMETHYL) 5 (2 OXOPROPYL) 1,1' BIPYRROLIDIN 2 ONE; 5 METHYL 2 (1 METHYL 1 PHENYLETHYL)CYCLOHEXYL (4,4 DIFLUORO 5 OXOPYRROLIDIN 2 YL)ACETATE; 5 METHYL 2 (1 METHYL 1 PHENYLETHYL)CYCLOHEXYL (5,5 DIFLUORO 1 METHOXY 6 OXOPIPERIDIN 2 YL)ACETATE; 5 METHYL 2 (1 METHYL 1 PHENYLETHYL)CYCLOHEXYL [4,4 DIFLUORO 1 (4 METHOXYPHENYL) 5 OXOPYRROLIDIN 2 YL]ACETATE; 5 METHYL 2 (1 METHYL 1 PHENYLETHYL)CYCLOHEXYL [4,4 DIFLUORO 1 METHOXY 5 OXOPYRROLIDIN 2 YL]ACETATE; 5 METHYL 2 (1 METHYL 1 PHENYLETHYL)CYCLOHEXYL [5,5 DIFLUORO 1 (4 METHOXYPHENYL) 6 OXOPYRROLIDIN 2 YL]ACETATE; ALPHA,ALPHA DIFLUORINATED LACTAM DERIVATIVE; ETHYL (4,4 DIFLUORO 1 METHOXY 5 OXOPYRROLIDIN 2 YL)ACETATE; ETHYL (5,5 DIFLUORO 1 METHOXY 6 OXOPIPERIDIN 2 YL)ACETATE; ETHYL 5,5 DIFLUORO 5 [(4 METHOXYPHENYL)AMINO] 6 OXOHEX 2 ENOATE; ETHYL 5,5 DIFLUORO 6 (METHOXYAMINO) 6 OXOHEX 2 ENOATE; ETHYL 6,6 DIFLUORO 7 (METHOXYAMINO) 7 OXOHEPT 2 ENOATE; ETHYL 6,6 DIFLUORO 7 [(4 METHOXYPHENYL)AMINO] 7 OXOHEPT 2 ENOATE; ETHYL [4,4 DIFLUORO 1 (4 METHOXYPHENYL) 5 OXOPYRROLIDIN 2 YL]ACETATE; ETHYL [4,4 DIFLUORO 2' (METHOXYMETHYL) 5 OXO 1,1' BIPYRROLIDIN 2 YL]ACETATE; ETHYL [5,5 DIFLUORO 1 (4 METHOXYPHENYL) 6 OXOPIPERIDIN 2 YL]ACETATE; ETHYL [5,5 DIFLUORO 1 [2 (METHOXYMETHYL)PYRROLIDIN 1 YL] 6 OXOPIPERIDIN 2 YL]ACETATE; LACTAM DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CATALYSIS; CHEMICAL REACTION; CHEMICAL STRUCTURE; CONJUGATION; CROSS METATHESIS; CYCLIZATION; MICHAEL ADDITION; MOLECULAR INTERACTION; REACTION ANALYSIS; STEREOCHEMISTRY; SYNTHESIS;

EID: 84861841704     PISSN: 00397881     EISSN: 1437210X     Source Type: Journal    
DOI: 10.1055/s-0031-1290964     Document Type: Article

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