Novel oral delivery system of indomethacin by solidified mPEG-PDLLA micelles: In vivo study

Drug Delivery

Volumn 19, Issue 4, 2012, Pages 232-237

  Ouahab, Ammar ^a   Shen, Yan ^a   Tu, Jia Sheng ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

in vitro dissolution; in vivo pharmacokinetic; Indomethacin; Poorly soluble drugs; Solidified polymeric micelles

Indexed keywords

ACETONE; COPOLYMER; CROSPOVIDONE; INDOMETACIN; METHOXY POLY(ETHYLENE GLYCOL) POLY(DEXTRO, LEVO LACTIDE) COPOLYMER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ADSORPTION; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM; DRUG SOLUBILITY; IN VITRO STUDY; IN VIVO STUDY; MALE; MAXIMUM PLASMA CONCENTRATION; MICELLE; NONHUMAN; PH; PRIORITY JOURNAL; RAT; SUSPENSION;

ADMINISTRATION, ORAL; ANIMALS; DRUG DELIVERY SYSTEMS; INDOMETHACIN; MALE; MICELLES; POLYESTERS; POLYETHYLENE GLYCOLS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84861834554     PISSN: 10717544     EISSN: 15210464     Source Type: Journal    
DOI: 10.3109/10717544.2012.690109     Document Type: Article

References (15)

1. Sweetman SC. Martindale: the complete drug reference. London: Pharmaceutical Press, 2005;47.
2. Löbenberg R, Amidon GL. Modern bioavailability, bioequivalence and biopharmaceutics classifcation system. New scientifc approaches to international regulatory standards. Eur J Pharm Biopharm 2000;50:3-12.
3. Yokoyama M, Miyauchi M, Yamada N, Okano T, Sakurai Y, Kataoka K, Inoue S. Characterization and anticancer activity of the micelle-forming polymeric anticancer drug adriamycin-conjugated poly(ethylene glycol)-poly(aspartic acid) block copolymer. Cancer Res 1990;50:1693-1700.
4. Torchilin VP. Structure and design of polymeric surfactant-based drug delivery systems. J Control Release 2001;73:137-172.
5. Yokoyama M. Novel passive targetable drug delivery with polymeric micelles. San Diego: Academic Press, 1998;193-229.
6. Florence AT, Hussain N. Transcytosis of nanoparticle and dendrimer delivery systems: evolving vistas. Adv Drug Deliv Rev 2001;50 Suppl 1:S69-S89.
7. Andrianov AK, Payne LG. Polymeric carriers for oral uptake of microparticulates. Adv Drug Deliv Rev 1998;34:155-170.
8. Kataoka K, Harada A, Nagasaki Y. Block copolymer micelles for drug delivery: design, characterization and biological signifcance. Adv Drug Deliv Rev 2001;47:113-131.
9. Zhang X, Burt HM, Mangold G, Dexter D, Von Hof D, Mayer L, Hunter WL. Anti-tumor efcacy and biodistribution of intravenous polymeric micellar paclitaxel. Anticancer Drugs 1997;8:696-701.
10. Shin IG, Kim SY, Lee YM, Cho CS, Sung YK. Methoxy poly(ethylene glycol)/epsilon-caprolactone amphiphilic block copolymeric micelle containing indomethacin. I. Preparation and characterization. J Control Release 1998;51:1-11.
11. Yu BG, Okano T, Kataoka K, Sardari S, Kwon GS. In vitro dissociation of antifungal efcacy and toxicity for amphotericin B-loaded poly(ethylene oxide)-block-poly(beta benzyl L aspartate) micelles. J Control Release 1998;56:285-291.
12. Allen C, Han J, Yu Y, Maysinger D, Eisenberg A. Polycaprolactone-b- poly(ethylene oxide) copolymer micelles as a delivery vehicle for dihydrotestosterone. J Control Release 2000;63:275-286.
13. Jeong YI, Nah JW, Lee HC, Kim SH, Cho CS. Adriamycin release from fower-type polymeric micelle based on star-block copolymer composed of poly(gamma-benzyl L-glutamate) as the hydrophobic part and poly(ethylene oxide) as the hydrophilic part. Int J Pharm 1999;188:49-58.
14. Khan F, Katara R, Ramteke S. Enhancement of bioavailability of cefpodoxime proxetil using diferent polymeric microparticles. AAPS PharmSciTech 2010;11:1368-1375.
15. Ahuja N, Katare OP, Singh B. Studies on dissolution enhancement and mathematical modeling of drug release of a poorly water-soluble drug using water-soluble carriers. Eur J Pharm Biopharm 2007;65:26-38.