Clinical outcome in Japanese elderly patients with non-valvular atrial fibrillation taking warfarin: A single-center observational study

Thrombosis Research

Volumn 130, Issue 1, 2012, Pages 21-26

  Naganuma, Miyoko ^a   Shiga, Tsuyoshi ^a,b   Sato, Kumi ^c   Murasaki, Kagari ^b   Hashiguchi, Masayuki ^d   Mochizuki, Mayumi ^d   Hagiwara, Nobuhisa ^b  

^a TOKYO WOMEN S MEDICAL UNIVERSITY MEDICAL CENTER EAST   (Japan)

^b TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^c JICHI MEDICAL UNIVERSITY   (Japan)

^d KEIO UNIVERSITY   (Japan)

Author keywords

atrial fibrillation; bleeding; elderly; Japanese; stroke; warfarin

Indexed keywords

WARFARIN;

AGED; ARTICLE; BLEEDING; BRAIN ISCHEMIA; COHORT ANALYSIS; DIABETES MELLITUS; FEMALE; FOLLOW UP; HAZARD RATIO; HEART ATRIUM FIBRILLATION; HUMAN; INTERNATIONAL NORMALIZED RATIO; JAPANESE; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; PRIORITY JOURNAL; SAFETY; SCORING SYSTEM; STROKE; THROMBOEMBOLISM; TRANSIENT ISCHEMIC ATTACK; TREATMENT OUTCOME;

AGED; AGED, 80 AND OVER; ANTICOAGULANTS; ATRIAL FIBRILLATION; COHORT STUDIES; FEMALE; HEMORRHAGE; HUMANS; INTERNATIONAL NORMALIZED RATIO; ISCHEMIC ATTACK, TRANSIENT; MALE; PROTHROMBIN TIME; STROKE; THROMBOEMBOLISM; TREATMENT OUTCOME; WARFARIN;

EID: 84861831358     PISSN: 00493848     EISSN: 18792472     Source Type: Journal    
DOI: 10.1016/j.thromres.2011.11.005     Document Type: Article

References (41)

1. W.M. Feinberg, J.L. Blackshear, A. Laupacis, R. Kronmal, and R.G. Hart Prevalence, age distribution, and gender of patients with atrial fibrillation. Analysis and implications Arch Intern Med 155 1995 469 473
2. A.S. Go, E.M. Hylek, K.A. Phillips, Y. Chang, L.E. Henault, and J.V. Selby Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the AnTicoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study JAMA 285 2001 2370 2375
3. P.A. Wolf, R.D. Abbott, and W.B. Kannel Atrial fibrillation as an indepemdent risk factor for stroke: the Framingham Heart Study Stroke 22 1991 983 988
4. E.J. Benjamin, P.A. Wolf, R.B. D'Agostino, H. Silbershatz, W.B. Kannel, and D. Levy Impact of atrial fibrillation on the risk of death: the Framingham Heart Study Circulation 98 1998 946 952
5. T.J. Wang, M.G. Larson, D. Levy, R.S. Vasan, E.P. Leip, and P.A. Wolf Temporal relations of atrial fibrillation and congestive heart failure and their joint influence on mortality: the Framingham Heart Study Circulation 107 2003 2920 2925
6. P. Dorian, W. Jung, D. Newman, M. Paquette, K. Wood, and G.M. Ayers The impairment of health-related quality of life in patients with intermittent atrial fibrillation: implications for the assessment of investigational therapy J Am Coll Cardiol 36 2000 1303 1309
7. Atrial Fibrillation Investigators Risk factors for stroke and efficacy of antithrombotic therapy in atrial fibrillation. Analysis of pooled data from five randomized controlled trials Arch Intern Med 154 1994 1449 1457
8. M. Hughes, and G.Y. Lip Stroke and thromboembolism in atrial fibrillation: a systematic review of stroke risk factors, risk stratification schema and cost effectiveness data Thromb Haemost 99 2008 295 304
9. Stroke Risk in Atrial Fibrillation Working Group Independent predictors of stroke in patients with atrial fibrillation: a systematic review Neurology 69 2007 546 554
10. A.J. Camm, P. Kirchhof, G.Y. Lip, U. Schotten, I. Savelieva, and S. Ernst Guidelines for the management of atrial fibrillation: The Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC) Eur Heart J 31 2010 2369 2429
11. E.M. Hylek, A.S. Go, Y. Chang, N.G. Jensvold, L.E. Henault, and J.V. Selby Effect of intensity of oral anticoagulation on stroke severity and mortality in atrial fibrillation N Engl J Med 349 2003 1019 1026
12. V. Fuster, L.E. Ryden, D.S. Cannom, H.J. Crijns, A.B. Curtis, and K.A. Ellenbogen ACC/AHA/ESC 2006 Guidelines for the Management of Patients with Atrial Fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 Guidelines for the Management of Patients With Atrial Fibrillation): developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society Circulation 114 2006 e257 e354
13. J. Mant, F.D.R. Hobbs, K. Fletcher, A. Roalfe, D. Fitzmaurice, and G.Y. Lip Warfarin versus aspirin for stroke prevention in an elderly community population with atrial fibrillation (the Birmingham Atrial Fibrillation Treatment of the Aged Study, BAFTA): a randomised controlled trial Lancet 370 2007 493 503
14. D.E. Singer, Y. Chang, M.C. Fang, L.H. Borowsky, N.K. Pomernacki, and N. Udaltsova The net clinical benefit of warfarin anticoagulation in atrial fibrillation Ann Intern Med 151 2009 297 305
15. A. Rash, T. Downes, R. Portner, W.W. Yeo, N. Morgan, and K.S. Channer A randomized controlled trial of warfarin versus aspirin for stroke prevention in octogenarians with atrial fibrillation (WASPO) Age Ageing 36 2007 151 156
16. D.E. Singer, G.W. Albers, J.E. Dalen, M.C. Fang, A.S. Go, and J.L. Halperin Antithrombotic therapy in atrial fibrillation: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition) Chest 133 2008 546S 592S
17. JCS Joint Working Group Guidelines for pharmacotherapy of atrial fibrillation (JCS 2008)-Digest version- Circ J 74 2010 2479 2500
18. T. Yamaguchi for Japanese Nonvalvular Atrial Fibrillation-Embolism Secondary Prevention Cooperative Study Group Optimal intensity of warfarin therapy for secondary prevention of stroke in patients with nonvalvular atrial fibrillation: A multicenter, prospective,randomized trial. Stroke 31 2000 817 821
19. M. Yasaka, K. Minematsu, and T. Yamaguchi Optimal intensity of international normalized ratio in warfarin therapy for secondary prevention of stroke in patients with non-valvular atrial fibrillation Intern Med 40 2001 1183 1188
20. S.A. Hunt, W.T. Abraham, M.H. Chin, A.M. Feldman, G.S. Francis, and T.G. Ganiats 2009 Focused update incorporated into the ACC/AHA 2005 guidelines for the diagnosis and management of heart failure in adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines Circulation 119 2009 e391 e479
21. F.R. Rosendaal, S.C. Cannegieter, F.J. van der Meer, and E. Briët A method to determine the optimal intensity of oral anticoagulant therapy Thromb Haemost 69 1993 236 239
22. S.J. Connolly, J. Pogue, J. Eikelboom, G. Flaker, P. Commerford, and M.G. Franzosi Benefit of oral anticoagulant over antiplatelet therapy in atrial fibrillation depends on the quality of international normalized ratio control achieved by centers and countries as measured by time in therapeutic range Circulation 118 2008 2029 2037
23. Stroke Prevention in Atrial Fibrillation Investigators Warfarin versus aspirin for prevention of thromboembolism in atrial fibrillation: Stroke Prevention in Atrial Fibrillation II Study Lancet 343 1994 687 691
24. R. Marinigh, G.Y. Lip, N. Fiotti, C. Giansante, and D.A. Lane Age as a risk factor for stroke in atrial fibrillation patients: Implications for thromboprophylaxis J Am Coll Cardiol 56 2010 827 837
25. G.P. Aithal, C.P. Day, P.J. Kesteven, and A.K. Daly Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications Lancet 353 1999 717 719
26. T. Yin, and T. Miyata Warfarin dose and the pharmacogenomics of CYP2C9 and VKORC1-Rationale and perspectives Thromb Res 120 2007 1 10
27. F. Dentali, J.D. Douketis, W. Lim, and M. Crowther Combined aspirin-oral anticoagulant therapy compared with oral anticoagulant therapy alone among patients at risk for cardiovascular disease: a meta-analysis of randomized trials Arch Intern Med 167 2007 117 124
28. D.A. Lane, P.W. Kamphuisen, P. Minini, H.R. Büller, and G.Y. Lip Bleeding risk in patients with atrial fibrillation: The AMADEUS Study Chest 140 2011 146 155
29. T.I. Shireman, P.A. Howard, T.F. Kresowik, and E.F. Ellerbeck Combined anticoagulant-antiplatelet use and major bleeding events in elderly atrial fibrillation patients Stroke 35 2004 2362 2367
30. K.H. Tay, G.Y. Lip, and D.A. Lane Bleeding rates in elderly patients on vitamin K antagonist therapy for nonvalvular atrial fibrillation Blood Coagul Fibrinolysis 20 2009 392 393
31. C. van Walraven, R.G. Hart, S. Connolly, P.C. Austin, J. Mant, and F.D. Hobbs Effect of age on stroke prevention therapy in patients with atrial fibrillation: the atrial fibrillation investigators Stroke 40 2009 1410 1416
32. D. Poli, E. Antonucci, E. Grifoni, R. Abbate, G.F. Gensini, and D. Prisco Bleeding risk during oral anticoagulation in atrial fibrillation patients older than 80 years J Am Coll Cardiol 54 2009 999 1002
33. H. Inoue, T. Nozawa, T. Hirai, A. Iwasa, K. Okumura, and J.D. Lee Accumulation of risk factors increases risk of thromboembolic events in patients with nonvalvular atrial fibrillation Circ J 70 2006 651 656
34. S. Suzuki, T. Yamashita, T. Kato, T. Fujino, K. Sagara, and H. Sawada Incidence of major bleeding complication of warfarin therapy in Japanese patients with atrial fibrillation Circ J 71 2007 761 765
35. J.H. You, F.W. Chan, R.S. Wong, and G. Cheng Is INR between 2.0 and 3.0 the optimal level for Chinese patients on warfarin therapy for moderate-intensity anticoagulation? Br J Clin Pharmacol 59 2005 582 587
36. A.Y.-J. Shen, J.F. Yao, S.S. Brar, M.B. Jorgensen, and W. Chen Racial/ethnic differences in the risk of intracranial hemorrhage among patients with atrial fibrillation J Am Coll Cardiol 50 2007 309 315
37. H. Tanaka, Y. Ueda, M. Hayashi, C. Date, T. Baba, and H. Yamashita Risk factors for cerebral hemorrhage and cerebral infarction in a Japanese rural community Stroke 13 1982 62 73
38. C. Ayala, K.J. Greenlund, J.B. Croft, N.L. Keenan, R.S. Donehoo, and W.H. Giles Racial/ethnic disparities in mortality by stroke subtype in the United States, 1995-1998 Am J Epidemiol 154 2001 1057 1063
39. J. Fang, S.H. Foo, J.S. Jeng, P.K. Yip, and M.H. Alderman Clinical characteristics of stroke among Chinese in New York City Ethn Dis 14 2004 378 383
40. A.L. Klatsky, G.D. Friedman, S. Sidney, H. Kipp, A. Kubo, and M.A. Armstrong Risk of hemorrhagic stroke in Asian American ethnic groups Neuroepidemiology 25 2005 26 31
41. A. Odén, M. Fahlén, and R.G. Hart Optimal INR for prevention of stroke and death in atrial fibrillation: a critical appraisal Thromb Res 117 2006 493 499