Cellular membrane phospholipids act as a depository for quaternary amine containing drugs thus competing with the acetylcholine/nicotinic receptor

Journal of Proteome Research

Volumn 11, Issue 6, 2012, Pages 3382-3389

  Barbacci, Damon ^a,b   Jackson, Shelley N ^a   Muller, Ludovic ^a   Egan, Thomas ^b   Lewis, Ernest K ^b   Schultz, J Albert ^b   Woods, Amina S ^a  

^a NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^b Ionwerks Inc   (United States)

Author keywords

drug lipid interactions; Drug protein interactions; guanidinium; MALDI IM TOF MS; noncovalent complexes; phospholipids; quaternary amines

Indexed keywords

ACETYLCHOLINE; AMINE; CHOLINERGIC RECEPTOR; DECAMETHONIUM; EPITOPE; MEMBRANE PHOSPHOLIPID; NICOTINIC RECEPTOR; HEXAMETHONIUM; PEPTIDE FRAGMENT; PHOSPHOLIPID; PROTEIN BINDING; SUXAMETHONIUM;

ARTICLE; BINDING AFFINITY; BINDING COMPETITION; DRUG BINDING; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; AMINO ACID SEQUENCE; CHEMISTRY; DRUG SCREENING; MASS SPECTROMETRY; MOLECULAR GENETICS; PROCEDURES;

ACETYLCHOLINE; AMINO ACID SEQUENCE; BINDING, COMPETITIVE; DECAMETHONIUM COMPOUNDS; DRUG EVALUATION, PRECLINICAL; HEXAMETHONIUM; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PHOSPHOLIPIDS; PROTEIN BINDING; RECEPTORS, NICOTINIC; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SUCCINYLCHOLINE;

EID: 84861805409     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr300184g     Document Type: Article

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