Is lavender an anxiolytic drug? A systematic review of randomised clinical trials

Phytomedicine

Volumn 19, Issue 8-9, 2012, Pages 825-835

  Perry, R ^a   Terry, R ^a   Watson, L K ^a   Ernst, E ^a  

^a UNIVERSITY OF EXETER   (United Kingdom)

Author keywords

Anxiety; Anxiolytic drug; Lavender; RCT; Stress; Systematic review

Indexed keywords

ANXIOLYTIC AGENT; HERBACEOUS AGENT; LAVENDER OIL;

ANXIETY DISORDER; AROMATHERAPY; CINAHL; COCHRANE LIBRARY; DRUG EFFICACY; EMBASE; HUMAN; LAVENDER; MEDLINE; PRIORITY JOURNAL; PSYCINFO; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SYSTEMATIC REVIEW;

LAVANDULA; LAVANDULA ANGUSTIFOLIA;

EID: 84861805220     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2012.02.013     Document Type: Article

References (41)

1. Anon, 2011. Shirodhara Massage. http://www.mindbodysoul.tv/health/ shirodhara-massage.html (accessed 25.05.11).
2. I. Boutron, D. Moher, P. Tugwell, B. Giraudeau, S. Poiraudeau, R. Nizard, and P. Ravaud A checklist to evaluate a report of a nonpharmacological trial (CLEAR NPT) was developed using consensus Journal of Clinical Epidemiology 58 2005 1233 1240
3. R. Braden, S. Reichow, and M.A. Halm The use of the essential oil lavandin to reduce preoperative anxiety in surgical patients Journal of Perianesthesia Nursing 24 6 2009 348 355
4. B.F. Bradley, S.L. Brown, S. Chu, and R.W. Lea Effects of orally administered lavender essential oil on responses to anxiety-provoking film clips Human Psychopharmacology 24 4 2009 319 330
5. L.F. Brum, E. Elisabetsky, and D. Souza Effects of linalool on ((3)H) MK801 and {(3)H} muscimol binding in mouse cortical membranes Phytotherapy Research 15 2001 422 425
6. J. Buckle Aromatherapy: does it matter which lavender essential oil is used Nursing Times 89 1993 32 35
7. H.M. Cavanagh, and J.M. Wilkinson Biological activities of lavender essential oil Phytotherapy Research 16 4 2002 301 308
8. J. Corner, N. Cawley, and S. Hildebrand An evaluation of the use of massage and essential oils in the wellbeing of cancer patients International Journal of Palliative Nursing 1 1995 67 73
9. I.H. Coulson, and A.S. Khan Facial pillow dermatitis due to lavender oil allergy Consult Dermatitis 41 1999 111
10. C. Dunn, J. Sleep, and D. Collett Sensing an improvement an experimental study to evaluate the use of aromatherapy, massage and periods of rest in an intensive care unit Journal of Advanced Nursing 21 1995 34 40
11. P.J. Easterbrook, J.A. Berlin, R. Gopalan, and D.R. Matthews Publication bias in clinical research Lancet 337 1991 867 872
12. E. Ernst Herbal medicinal products during pregnancy: are they safe? BJOG: An International Journal of Obstetric and Gynaecology 109 2002 227 235
13. E. Ernst 'First, do no harm' with complementary and alternative medicine Trends in Pharmacological Sciences 28 2 2007 48 50
14. E. Ernst Publication bias in complementary/alternative medicine Journal of Clinical Epidemiology 60 11 2007 1093 1094
15. E. Ernst, and M.H. Pittler Alternative therapy bias Nature 385 1997 480
16. J.J. Gagnier, H. Boon, P. Rochon, D. Moher, J. Barnes, C. Bombardier CONSORT Group Reporting randomized, controlled trials of herbal interventions: an elaborated CONSORT statement Annals of Internal Medicine 144 5 2006 364 367
17. P.H. Graham, L. Browne, H. Cox, and J. Graham Inhalation aromatherapy during radiotherapy: results of a placebo-controlled double-blind randomized trial Journal of Clinical Oncology 21 2003 2372 2376
18. S.J. Hossain, H. Aoshima, H. Koda, and Y. Kiso Fragrances in oolong tea that enhance the response of GABAA receptors Bioscience, Biotechnology, and Biochemistry 68 2004 1842 1848
19. S. Howard, and B.M. Hughes Expectancies, not aroma, explain impact of lavender aromatherapy on psychophysiological indices of relaxation in young healthy women British Journal of Health Psychology 13 Pt 4 2008 603 617
20. Y. Hoya, I. Matsumura, T. Fujita, and K. Yanaga The use of nonpharmacological interventions to reduce anxiety in patients undergoing gastroscopy in a setting with an optimal soothing environment Gastroenterology Nursing 31 6 2008 395 399
21. A.R. Jadad, R.A. Moore, D. Carrol, C. Jenkinson, D.J.M. Reynolds, D.J. Gavaghan, and H.J. McQuay Assessing the quality of reports of randomized clinical trials - is blinding necessary? Controlled Clinical Trials 17 1996 1 12
22. S. Kasper, M. Gastpar, W.E. ller, H.P. Volz, H.J. ller, and A. Dienel Silexan, an orally administered Lavandula oil preparation, is effective in the treatment of 'subsyndromal' anxiety disorder: a randomized, double-blind, placebo controlled trial International Clinical Psychopharmacology 25 5 2010 277 287
23. M. Kritsidima, T. Newton, and K. Asimakopoulou The effects of lavender scent on dental patient anxiety levels: a cluster randomised-controlled trial Community Dentistry & Oral Epidemiology 38 1 2010 83 87
24. A.K. Kutlu, E. Yilmaz, and D. Çeçen Effects of aroma inhalation on examination anxiety Teaching & Learning in Nursing 3 4 2008 125 130
25. A.Y. Leung, and S. Foster Encyclopedia of Common Natural Ingredients used in Food, Drugs and Cosmetics 1996 Wiley New York pp. 339-342
26. N. Morris The effects of lavender (Lavendula angustifolium) baths on psychological well-being: two exploratory randomised control trials Complementary Therapies in Medicine 10 4 2002 223 228
27. N. Motomura, A. Sakurai, and Y. Yotsuya A psychophysiological study of lavender odorant Memoirs of Osaka Kyoiku University Series III 47 2 1999 281 287
28. N. Motomura, A. Sakurai, and Y. Yotsuya Reduction of mental stress with lavender odorant Perceptual & Motor Skills 93 3 2001 713 718
29. L. Muzzarelli, M. Force, and M. Sebold Aromatherapy and reducing preprocedural anxiety: a controlled prospective study Gastroenterology Nursing 29 6 2006 466 471
30. H. Nakane, O. Assami, Y. Yamada, T. Harada, N. Matsui, and T. Kanno Salivary chromogranin A as an index of psychosomatic stress response Biomedical Research 19 1998 401 406
31. H. Nakane, O. Assami, Y. Yamada, and H. Ohira Effect of negative air ions on computer operation, anxiety, and salivary chromogranin-A-like immunoreactivity International Journal of Psychophysiology 46 2002 85 89
32. D. Nord, and J. Belew Effectiveness of the essential oils lavender and ginger in promoting children's comfort in a perianesthesia setting Journal of Perianesthesia Nursing 24 5 2009 307 312
33. W.N. Setzer Essential oils and anxiolytic aromatherapy Natural Product Communications 4 9 2009 1305 1316
34. S. Sgoutas-Emch, T. Fox, M. Preston, C. Brooks, and E. Serber Stress management: aromatherapy as an alternative Scientific Review of Alternative Medicine 5 2 2001 90 95
35. K. Soden, K. Vincent, S. Craske, C. Lucas, and S. Ashley A randomized controlled trial of aromatherapy massage in a hopsice setting Palliative Medicine 18 2004 87 92
36. M. Toda, and K. Morimoto Effect of lavender aroma on salivary endocrinological stress markers Archives of Oral Biology 53 10 2008 964 968
37. A.P. Verhagen, H.C.W. de Vet, R.A. De Bie, A.G. Kessels, M. Boers, L.M. Bouter, and P.G. Knipschild The Delphi list: a criteria list for quality assessment of randomised clinical trials for conducting systematic reviews developed by Delphi consensus Journal of Clinical Epidemiology 51 12 1998 1235 1241
38. M. Willman, J. Bink, and J. Swain Using an essential oil with breast biopsy patients in an outpatient setting Oncology Nursing Forum 36 3 2009 47 48
39. H.U. Wittchen, F. Jacobi, J. Rehm, A. Gustavsson, M. Svensson, B. Jönsson, J. Olesen, C. Allgulander, J. Alonso, C. Faravelli, L. Fratiglioni, P. Jennum, R. Lieb, A. Maercker, J. van Os, M. Preisig, L. Salvador-Carulla, R. Simon, and H.C. Steinhausen The size and burden of mental disorders and other disorders of the brain in Europe 2010 European Neuropsychopharmacology 21 9 2011 655 679
40. H. Woelk, and S. Schlafke A multi-center, double-blind, randomised study of the Lavender oil preparation Silexan in comparison to Lorazepam for generalized anxiety disorder Phytomedicine 17 2 2010 94 99
41. F. Xu, K. Uebaba, H. Ogawa, T. Tatsuse, B.H. Wang, T. Hisajima, and S. Venkatraman Pharmaco-physio-psychologic effect of Ayurvedic oil-dripping treatment using an essential oil from Lavendula angustifolia Journal of Alternative & Complementary Medicine 14 8 2008 947 956