Increased heparanase level and procoagulant activity in orthopedic surgery patients receiving prophylactic dose of enoxaparin

Thrombosis Research

Volumn 130, Issue 1, 2012, Pages 129-134

  Peled, Eli ^a   Rovitsky, Alexey ^a   Axelman, Elena ^b   Norman, Doron ^a   Brenner, Benjamin ^b   Nadir, Yona ^b  

^a Rambam Health Care Campus ^*  (Israel)

^b RAMBAM MEDICAL CENTER   (Israel)

Author keywords

Coagulation; Heparanase; Orthopedic surgery

Indexed keywords

BLOOD CLOTTING FACTOR 10A; CHROMOGENIC SUBSTRATE; ENOXAPARIN; HEPARANASE; PROCOAGULANT; THROMBIN; THROMBOPLASTIN;

ADULT; AGED; ANTICOAGULATION; ARTICLE; BLOOD LEVEL; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HIP FRACTURE; HIP OSTEOARTHRITIS; HIP SURGERY; HUMAN; KNEE SURGERY; MAJOR CLINICAL STUDY; MALE; POSTOPERATIVE PERIOD; PREOPERATIVE PERIOD; PRIORITY JOURNAL; PROPHYLAXIS; THROMBOSIS;

AGED; ANTICOAGULANTS; ENOXAPARIN; FACTOR XA; FEMALE; GLUCURONIDASE; HIP; HUMANS; KNEE; MALE; MIDDLE AGED; ORTHOPEDIC PROCEDURES; THROMBIN; THROMBOPLASTIN; THROMBOSIS;

EID: 84861800535     PISSN: 00493848     EISSN: 18792472     Source Type: Journal    
DOI: 10.1016/j.thromres.2011.09.021     Document Type: Article

References (30)

1. W.H. Geerts, D. Bergqvist, G.F. Pineo, J.A. Heit, C.M. Samama, M.R. Lassen, and C.W. Colwell Prevention of venous thromboembolism: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition) Chest 133 2008 381S 453S
2. C. Freeman, and C.R. Parish Human platelet heparanase: purification, characterization and catalytic activity Biochem J 330 Pt 3 1998 1341 1350
3. D.S. Pikas, J.P. Li, I. Vlodavsky, and U. Lindahl Substrate specificity of heparanases from human hepatoma and platelets J Biol Chem 273 1998 18770 18777
4. L.A. Dempsey, G.J. Brunn, and J.L. Platt Heparanase, a potential regulator of cell-matrix interactions Trends Biochem Sci 25 2000 349 351
5. C.R. Parish, C. Freeman, and M.D. Hulett Heparanase: a key enzyme involved in cell invasion Biochim Biophys Acta 1471 2001 M99 M108
6. I. Vlodavsky, and Y. Friedmann Molecular properties and involvement of heparanase in cancer metastasis and angiogenesis J Clin Invest 108 2001 341 347
7. O. Goldshmidt, E. Zcharia, M. Cohen, H. Aingorn, I. Cohen, L. Nadav, B.Z. Katz, B. Geiger, and I. Vlodavsky Heparanase mediates cell adhesion independent of its enzymatic activity FASEB J 17 2003 1015 1025
8. S. Gingis-Velitski, A. Zetser, M.Y. Flugelman, I. Vlodavsky, and N. Ilan Heparanase induces endothelial cell migration via protein kinase B/Akt activation J Biol Chem 279 2004 23536 23541
9. A. Zetser, Y. Bashenko, E. Edovitsky, F. Levy-Adam, I. Vlodavsky, and N. Ilan Heparanase induces vascular endothelial growth factor expression: correlation with p38 phosphorylation levels and Src activation Cancer Res 66 2006 1455 1463
10. Y. Nadir, B. Brenner, A. Zetser, N. Ilan, I. Shafat, E. Zcharia, O. Goldshmidt, and I. Vlodavsky Heparanase induces tissue factor expression in vascular endothelial and cancer cells J Thromb Haemost 4 2006 2443 2451
11. Y. Nadir, B. Brenner, S. Gingis-Velitski, F. Levy-Adam, N. Ilan, E. Zcharia, E. Nadir, and I. Vlodavsky Heparanase induces tissue factor pathway inhibitor expression and extracellular accumulation in endothelial and tumor cells Thromb Haemost 99 2008 133 141
12. Y. Nadir, B. Brenner, L. Fux, I. Shafat, J. Attias, and I. Vlodavsky Heparanase enhances factor Xa generation in the presence of tissue-factor and factor VIIa Haematologica 95 2010 1927 1934
13. R.W. Li, C. Freeman, D. Yu, E.J. Hindmarsh, K.E. Tymms, C.R. Parish, and P.N. Smith Dramatic regulation of heparanase activity and angiogenesis gene expression in synovium from patients with rheumatoid arthritis Arthritis Rheum 58 2008 1590 1600
14. I. Shafat, E. Zcharia, B. Nisman, Y. Nadir, F. Nakhoul, I. Vlodavsky, and N. Ilan An ELISA method for the detection and quantification of human heparanase Biochem Biophys Res Commun 341 2006 958 963
15. A. Zetser, F. Levy-Adam, V. Kaplan, S. Gingis-Velitski, Y. Bashenko, S. Schubert, M.Y. Flugelman, I. Vlodavsky, and N. Ilan Processing and activation of latent heparanase occurs in lysosomes J Cell Sci 117 2004 2249 2258
16. Y. Nadir, Y. Kenig, A. Drugan, I. Shafat, and B. Brenner An assay to evaluate heparanase procoagulant activity Thromb Res 128 2011 e3 e8
17. J. teffel, A. Akhmedov, H. Greutert, T.F. Luscher, and F.C. Tanner Histamine induces tissue Sfactor expression: implications for acute coronary syndromes Circulation 112 2005 341 349
18. M. Camera, P.L. Giesen, J. Fallon, B.M. Aufiero, M. Taubman, E. Tremoli, and Y. Nemerson Cooperation between VEGF and TNF-alpha is necessary for exposure of active tissue factor on the surface of human endothelial cells Arterioscler Thromb Vasc Biol 19 1999 531 537
19. A.D. Schecter, P.L. Giesen, O. Taby, C.L. Rosenfield, M. Rossikhina, B.S. Fyfe, D.S. Kohtz, J.T. Fallon, Y. Nemerson, and M.B. Taubman Tissue factor expression in human arterial smooth muscle cells. TF is present in three cellular pools after growth factor stimulation J Clin Invest 100 1997 2276 2285
20. A.S. Wolberg, D.M. Monroe, H.R. Roberts, and M.R. Hoffman Tissue factor de-encryption: ionophore treatment induces changes in tissue factor activity by phosphatidylserine-dependent and -independent mechanisms Blood Coagul Fibrinolysis 10 1999 201 210
21. R. Biggs, and K.W. Denson The Fate of Prothrombin and Factors Viii, Ix and X Transfused to Patients Deficient in These Factors Br J Haematol 9 1963 532 547
22. J.V. Sorensen, H.B. Rahr, H.P. Jensen, L.C. Borris, M.R. Lassen, and P. Ejstrud Markers of coagulation and fibrinolysis after fractures of the lower extremities Thromb Res 65 1992 479 486
23. E. Cofrancesco, M. Cortellaro, A. Corradi, F. Ravasi, and F. Bertocchi Coagulation activation markers in the prediction of venous thrombosis after elective hip surgery Thromb Haemost 77 1997 267 269
24. O.E. Dahl, T. Aspelin, H. Arnesen, I. Seljeflot, P. Kierulf, R. Ruyter, and T. Lyberg Increased activation of coagulation and formation of late deep venous thrombosis following discontinuation of thromboprophylaxis after hip replacement surgery Thromb Res 80 1995 299 306
25. H.J. Siemens, S. Brueckner, S. Hagelberg, T. Wagner, and P. Schmucker Course of molecular hemostatic markers during and after different surgical procedures J Clin Anesth 11 1999 622 629
26. Y. Lopez, J.A. Paramo, J.R. Valenti, F. Pardo, R. Montes, and E. Rocha Hemostatic markers in surgery: a different fibrinolytic activity may be of pathophysiological significance in orthopedic versus abdominal surgery Int J Clin Lab Res 27 1997 233 237
27. E. Cofrancesco, M. Cortellaro, P. Leonardi, A. Corradi, F. Ravasi, and F. Bertocchi Markers of hemostatic system activation during thromboprophylaxis with recombinant hirudin in total hip replacement Thromb Haemost 75 1996 407 411
28. O. Ostrovsky, M. Korostishevsky, I. Levite, M. Leiba, H. Galski, E. Gazit, I. Vlodavsky, and A. Nagler Characterization of HPSE gene single nucleotide polymorphisms in Jewish populations of Israel Acta Haematol 117 2007 57 64
29. O. Ostrovsky, M. Korostishevsky, I. Levite, M. Leiba, H. Galski, I. Vlodavsky, and A. Nagler Association of heparanase gene (HPSE) single nucleotide polymorphisms with hematological malignancies Leukemia 21 2007 2296 2303
30. S. Ralph, P.E. Brenchley, A. Summers, D.D. Rosa, R. Swindell, and G.C. Jayson Heparanase gene haplotype (CGC) is associated with stage of disease in patients with ovarian carcinoma Cancer Sci 98 2007 844 849