The salivary gland epithelial cell in Sjögren's syndrome: What are the steps involved in wounding or killing their secretory function?

Journal of Rheumatology

Volumn 39, Issue 6, 2012, Pages 1117-1119

  Fox, Robert I ^a  

^a SCRIPPS MEMORIAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 ANTIGEN; CD40 LIGAND; CORTICOSTEROID; FAS LIGAND; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR;

APOPTOSIS; CELL FUNCTION; CELL SECRETION; EDITORIAL; ENZYME ACTIVATION; EPITHELIUM CELL; HUMAN; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROTEIN FUNCTION; REGULATORY MECHANISM; RHEUMATOID ARTHRITIS; SALIVARY GLAND; SJOEGREN SYNDROME; T LYMPHOCYTE; UPREGULATION; XEROSTOMIA;

ANTIGENS, CD95; APOPTOSIS; BIOLOGICAL MARKERS; CD40 LIGAND; EPITHELIAL CELLS; HUMANS; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; SALIVARY GLANDS; SJOGREN'S SYNDROME; T-LYMPHOCYTES; UP-REGULATION;

EID: 84861800413     PISSN: 0315162X     EISSN: 14992752     Source Type: Journal    
DOI: 10.3899/jrheum.120278     Document Type: Editorial

References (16)

1. Ping L, Ogawa N, Zhang Y, Sugai S, Masaki Y, Weiguo X. p38 mitogen-activated protein kinase and nuclear factor-κB facilitate CD40-mediated salivary epithelial cell death. J Rheumatol 2012;39:1256-66.
2. Ping L, Ogawa N, Sugai S. Novel role of CD40 in Fas-dependent apoptosis of cultured salivary epithelial cells from patients with Sjögren's syndrome. Arthritis Rheum 2005;52:573-81. (Pubitemid 40216322)
3. Brookes SM, Price EJ, Venables PJ, Maini RN. Interferon-gamma and epithelial cell activation in Sjögren's syndrome. Br J Rheumatol 1995;34:226-31.
4. Fox RI, Bumol T, Fantozzi R, Bone R, Schreiber R. Expression of histocompatibility antigen HLA-DR by salivary gland epithelial cells in Sjögren's syndrome. Arthritis Rheum 1986;29:1105-11. (Pubitemid 16017801)
5. Attias MR, Kong L, Tortolero M, Maccarone BG, Nakabayashi T, Talal N, et al. CD4 mononuclear cell infiltrates and Fas/Fas ligand positive mammary gland cells in breast tissue from a patient with Sjogren's syndrome. J Rheumatol 1998;25:1226-31. (Pubitemid 28350904)
6. Gannot G, Bermudez D, Lillibridge D, Fox PC. Fas and Fas-mediated effects on a human salivary cell line in vitro: A model for immune-mediated exocrine damage in Sjogren's syndrome. Cell death and differentiation. Cell Death Differ 1998;5:743-50. (Pubitemid 28439114)
7. Ichikawa Y, Yoshida A, Horiki Y, Morita H, Uchiyama M, Shimiau H, et al. Abnormal expression of apoptosis related antigens, Fas and bcl-2 on circulating T-lymphocyte subsets in primary Sjogren's syndrome. Clin Exp Rheumatol 1995;13:307-13.
8. Kong L, Ogawa N, Nakabayashi T, Liu GT, D'Souza E, McGuff HS, et al. Fas and Fas ligand expression in the salivary glands of patients with primary Sjogren's syndrome. Arthritis Rheum 1997;40:87-97. (Pubitemid 27044040)
9. Beroukas D, Hiscock J, Gannon BJ, Jonsson R, Gordon TP, Waterman SA. Selective down-regulation of aquaporin-1 in salivary glands in primary Sjogren's syndrome. Lab Invest 2002;82:1547-52. (Pubitemid 35332913)
10. Beroukas D, Hiscock J, Jonsson R, Waterman SA, Gordon TP. Subcellular distribution of aquaporin 5 in salivary glands in primary Sjogren's syndrome. Lancet 2001;358:1875-6. (Pubitemid 34008658)
11. Steinfeld S, Cogan E, King LS, Agre P, Kiss R, Delporte C. Abnormal distribution of aquaporin-5 water channel protein in salivary glands from Sjogren's syndrome patients. Lab Invest 2001;81:143-8. (Pubitemid 32176377)
12. Manoussakis MN, Dimitriou ID, Kapsogeorgou EK, Xanthou G, Paikos S, Polihronis M, et al. Expression of B7 costimulatory molecules by salivary gland epithelial cells in patients with Sjogren's syndrome. Arthritis Rheum 1999;42:229-39. (Pubitemid 29072839)
13. Ohlsson M, Skarstein K, Bolstad AI, Johannessen AC, Jonsson R. Fas-induced apoptosis is a rare event in Sjogren's syndrome. Lab Invest 2001;81:95-105. (Pubitemid 32108643)
14. De Vita S. Ductal Fas antigen and the pathobiology of Sjogren's syndrome. Clin Exp Rheumatol 1996;14:231-4.
15. Damjanov N, Kauffman RS, Spencer-Green GT. Efficacy, pharmacodynamics, and safety of VX-702, a novel p38 MAPK inhibitor, in rheumatoid arthritis: Results of two randomized, double-blind, placebo-controlled clinical studies. Arthritis Rheum 2009;60:1232-41.
16. Genovese MC. Inhibition of p38: Has the fat lady sung? Arthritis Rheum 2009;60:317-20.