The effect of nicotine on anti-vascular endothelial growth factor therapy in a mouse model of neovascular age-related macular degeneration

Retina

Volumn 32, Issue 6, 2012, Pages 1171-1180

  Davis, Stephen J ^a   Lyzogubov, Valeriy V ^a   Tytarenko, Ruslana G ^a   Safar, Ammar N ^a   Bora, Nalini S ^a   Bora, Puran S ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

bungarotoxin; adiponectin; age related macular degeneration; bevacizumab; choroidal neovascularization; mouse model; nicotine acetylcholine receptor; platelet derived growth factor; smoking; vascular endothelial growth factor

Indexed keywords

ADIPONECTIN; ALPHA BUNGAROTOXIN; BEVACIZUMAB; DRINKING WATER; NICOTINE; NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA7; NICOTINIC RECEPTOR; PLATELET DERIVED GROWTH FACTOR; UNCLASSIFIED DRUG; VASCULOTROPIN; WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE MODEL; DRUG EFFECT; IMMUNOHISTOCHEMISTRY; LASER; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; RETINA MACULA AGE RELATED DEGENERATION; SUBRETINAL NEOVASCULARIZATION;

ADIPONECTIN; ANALYSIS OF VARIANCE; ANGIOGENESIS INHIBITORS; ANIMALS; ANTIBODIES, MONOCLONAL, HUMANIZED; BUNGAROTOXINS; CHOROID; CHOROIDAL NEOVASCULARIZATION; DISEASE MODELS, ANIMAL; IMMUNOHISTOCHEMISTRY; INTRAVITREAL INJECTIONS; MALE; MICE; MICE, INBRED C57BL; NICOTINE; RECEPTORS, NICOTINIC; RETINAL PIGMENT EPITHELIUM; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 84861793103     PISSN: 0275004X     EISSN: 15392864     Source Type: Journal    
DOI: 10.1097/IAE.0b013e31823496b8     Document Type: Article

References (31)

1. Cong R, Zhou B, Sun Q, et al. Smoking and the risk of age-related macular degeneration: a meta-analysis. Ann Epidemiol 2008;18:647-656.
2. Friedman DS, O'Colmain BJ, Muñoz B, et al. Prevalence of age-related macular degeneration in the United States. Arch Ophthalmol 2004;122:564-572.
3. Ferris FL III, Fine SL, Hyman L. Age-related macular degeneration and blindness due to neovascular maculopathy. Arch Ophthalmol 1984;102:1640-1642.
4. Rosenfeld PJ, Brown DM, Heier JS, et al. Ranibizumab for neovascular age-related macular degeneration. N Engl J Med 2006;355:1419-1431.
5. Gragoudas ES, Adamis AP, Cunningham ET, Jr, et al. Pegap-tanib for neovascular age-related macular degeneration. N Engl J Med 2004;351:2805-2816.
6. Weigert G, Michels S, Sacu S, et al. Intravitreal bevacizumab (Avastin) therapy versus photodynamic therapy plus intravi-treal triamcinolone for neovascular age-related macular degeneration: 6-month results of a prospective, randomized, controlled clinical study. Br J Ophthalmol 2008;92:356-360.
7. Ziemssen F, Grisanti S, Bartz-Schmidt KU, Spitzer MS. Off-label use of bevacizumab for the treatment of age-related macular degeneration: what is the evidence? Drugs Aging 2009;26:295-320.
8. Klein R, Klein BEK, Linton KL, et al. The Beaver Dam Eye Study: the relation of age-related maculopathy to smoking. Am J Epidemiol 1993;137:190-200.
9. Smith W, Mitchell P, Leeder SR. Smoking and age-related maculopathy. Arch Ophthalmol 1996;114:1518-1523.
10. Vingerling JR, Hofman A, Grobbee DE, de Jong PT. Age-related macular degeneration and smoking. Arch Ophthalmol 1996;114:1193-1196.
11. Suner IJ, Espinosa-Heidmann DG, Marin-Castano ME, et al. Nicotine increases size and severity of experimental choroidal neovascularization. Invest Ophthalmol Vis Sci 2004;45: 311-317.
12. Kiuchi K, Matsuoka M, Wu JC. Mecamylamine suppresses basal and nicotine-stimulated choroidal neovascularization. Invest Ophthalmol Vis Sci 2008;49:1705-1711.
13. Heeschen C, Jang JJ, Weis M, et al. Nicotine stimulates angiogenesis and promotes tumor growth and atherosclerosis. Nat Med 2001;7:833-839.
14. Kaliappan S, Jha P, Lyzogubov VV, et al. Alcohol and nicotine consumption exacerbates choroidal neovascularization by modulating the regulation of complement system. FEBS Letters 2008;582:3451-3458.
15. Funk M, Karl D, Georgopoulos M, et al. Neovascular age-related macular degeneration: intraocular cytokines and growth factors and the influence of therapy with ranibizumab. Ophthalmology 2009;116:2393-2399.
16. Grozio A, Catassi A, Cavalieri Z, et al. Nicotine, lung and cancer. Anticancer Agents Med Chem 2007;7:461-466.
17. Espinosa-Heidmann DG, Suner I, Hernandez EP, et al. Age as an independent risk factor for severity of experimental choroi-dal neovascularization. Invest Ophthalmol Vis Sci 2002;43: 1567-1573.
18. Bora PS, Kaliappana S, Lyzogubova VV, et al. Expression of adiponectin in choroidal tissue and inhibition of laser induced choroidal neovascularization by adiponectin. FEBS Letters 2007;581:1977-1982.
19. Bora PS, Hu Z, Tezel TH, et al. Immunotherapy for choroidal neovascularization in a laser-induced mouse model simulating exudative (wet) macular degeneration. Proc Natl Acad Sci USA 2003;100:2679-2684.
20. Brakenhielm E, Veitonmaki N, Kihara SCR, et al. Adiponectin-induced anti-angiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis. Proc Natl Acad Sci USA 2004;101:2476-2481.
21. Fruebis J, Tsao TS, Avorschi S, et al. Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. Proc Natl Acad Sci USA 2001;98:2005-2010.
22. Lyzogubov VV, Tytarenko RG, Thotakura S, et al. Inhibition of new vessel growth in mouse model of laser induced choroi-dal neovascularization by adiponectin peptide II. Cell Biol Int 2009;33:765-771.
23. Smith CJ, Hansch C. The relative toxicity of compounds in mainstream cigarette smoke condensate. Food Chem Toxicol 2000;38:637-646.
24. Heeschen C, Weis M, Aicher A, et al. A novel angiogenic pathway mediated by non-neuronal nicotinic acetylcholine receptors. J Clin Invest 2002;110:527-536.
25. Cooke JP, Ghebremariam YT. Endothelial nicotinic acetylcho-line receptors and angiogenesis. Trends Cardiovasc Med 2008; 18:247-253.
26. Yu L, Wu X, Cheng Z, et al. Interaction between bevacizumab and murine VEGF-A: a reassessment. Invest Ophthalmol Vis Sci 2008;49:522-527.
27. Wu JC, Chruscinski A, De Jesus Perez VA, et al. Cholinergic modulation of angiogenesis: role of the 7 nicotinic acetylcholine receptor. J Cell Biochem 2009;108:433-446.
28. Pons M, Marin-Castaño ME. Nicotine increases VEGF/PEDF ratio in retinal pigment epithelium: a possible mechanism for CNV in passive smokers with AMD. Invest Ophthalmol Vis Sci 2011. Epub ahead of print.
29. Patil AJ, Gramajo AL, Sharma A, et al. Differential effects of nicotine on retinal and vascular cells in vitro. Toxicology 2009; 259:69-76.
30. Dom AM, Buckley AW, Brown KC, et al. The {alpha}7-nicotinic acetylcholine receptor and MMP-2/9 pathway mediate the pro-angiogenic effect of nicotine in human retinal endothelial cells. Invest Ophthalmol Vis Sci 2011;52:4428-4438.
31. Lyzogubov VV, Tytarenko RG, Liu J, et al. Polyethylene glycol (PEG) induced mouse model of choroidal neovascula-rization. J Biol Chem 2011;286:16229-16237.