The dose-response of the anal sphincter region - An analysis of data from the MRC RT01 trial

Radiotherapy and Oncology

Volumn 103, Issue 3, 2012, Pages 347-352

  Buettner, Florian ^a   Gulliford, Sarah L ^a   Webb, Steve ^a   Sydes, Matthew R ^b   Dearnaley, David P ^a   Partridge, Mike ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b MRC CLINICAL TRIALS UNIT   (United Kingdom)

Author keywords

Anal sphincter; Dose effect relation; Prostate cancer; Radiotherapy

Indexed keywords

ADULT; ANUS SPHINCTER; ARTICLE; DOSE RESPONSE; DOSE TIME EFFECT RELATION; DOSIMETRY; HUMAN; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROSTATE CANCER; QUALITY OF LIFE; RADIATION DOSE DISTRIBUTION; SURFACE PROPERTY; THREE DIMENSIONAL IMAGING;

ANAL CANAL; DOSE-RESPONSE RELATIONSHIP, RADIATION; HUMANS; MALE; PROSTATIC NEOPLASMS; RADIATION INJURIES; RADIOTHERAPY DOSAGE; RADIOTHERAPY PLANNING, COMPUTER-ASSISTED; RADIOTHERAPY, CONFORMAL;

EID: 84861792556     PISSN: 01678140     EISSN: 18790887     Source Type: Journal    
DOI: 10.1016/j.radonc.2012.03.002     Document Type: Article

References (33)

1. J.W. Denham, P.C. O'Brien, R.H. Dunstan, J. Johansen, A. See, and C.S. Hamilton Is there more than one late radiation proctitis syndrome? Radiother Oncol 51 1999 43 53
2. J. Andreyev Gastrointestinal symptoms after pelvic radiotherapy: a new understanding to improve management of symptomatic patients Lancet Oncol 8 2007 1007 1017
3. C. Vargas, A. Martinez, L.L. Kestin, D. Yan, I. Grills, and D.S. Brabbins Dose-volume analysis of predictors for chronic rectal toxicity after treatment of prostate cancer with adaptive image-guided radiotherapy Int J Radiat Oncol Biol Phys 62 2005 1297 1308
4. M. Al-Abany, A.R. Helgason, A.K.A. Cronqvist, B. Lind, P. Mavroidis, and P. Wersll Toward a definition of a threshold for harmless doses to the anal-sphincter region and the rectum Int J Radiat Oncol Biol Phys 61 2005 1035 1044
5. S.T.H. Peeters, M.S. Hoogeman, W.D. Heemsbergen, A.A.M. Hart, P.C.M. Koper, and J.V. Lebesque Rectal bleeding, fecal incontinence, and high stool frequency after conformal radiotherapy for prostate cancer: normal tissue complication probability modeling Int J Radiat Oncol Biol Phys 66 2006 11 19
6. C. Fiorino, G. Fellin, T. Rancati, V. Vavassori, C. Bianchi, and V.C. Borca Clinical and dosimetric predictors of late rectal syndrome after 3D-CRT for localized prostate cancer: preliminary results of a multicenter prospective study Int J Radiat Oncol Biol Phys 70 2008 1130 1137
7. W.D. Heemsbergen, M.S. Hoogeman, G.A.M. Hart, J.V. Lebesque, and P.C.M. Koper Gastrointestinal toxicity and its relation to dose distributions in the anorectal region of prostate cancer patients treated with radiotherapy Int J Radiat Oncol Biol Phys 61 2005 1011 1018
8. S.T.H. Peeters, J.V. Lebesque, W.D. Heemsbergen, W.L.J. van Putten, A. Slot, and M.F.H. Dielwart Localized volume effects for late rectal and anal toxicity after radiotherapy for prostate cancer Int J Radiat Oncol Biol Phys 64 2006 1151 1161
9. P.C. Koper, P. Jansen, W. van Putten, M. van Os, A.J. Wijnmaalen, and J.V. Lebesque Gastro-intestinal and genito-urinary morbidity after 3d conformal radiotherapy of prostate cancer: observations of a randomized trial Radiother Oncol 73 2004 1 9
10. R.J. Smeenk, W.P.M. Hopman, A.L. Hoffmann, E.N.J.T. van Lin, and J.H.A.M. Kaanders Differences in radiation dosimetry and anorectal function testing imply that anorectal symptoms may arise from different anatomic substrates Int J Radiat Oncol Biol Phys 82 2012 145 152
11. Y. Maeda, M. Hyer, L. Lundby, and C. Norton Faecal incontinence following radiotherapy for prostate cancer: a systematic review Radiother Oncol 98 2011 145 153
12. P.C.M. Koper, W.D. Heemsbergen, M.S. Hoogeman, P.P. Jansen, G.A.M. Hart, and A.J. Wijnmaalen Impact of volume and location of irradiated rectum wall on rectal blood loss after radiotherapy of prostate cancer Int J Radiat Oncol Biol Phys 58 2004 1072 1082
13. S.L. Tucker, M. Zhang, L. Dong, R. Mohan, D. Kuban, and H.D. Thames Cluster model analysis of late rectal bleeding after IMRT of prostate cancer: a case-control study Int J Radiat Oncol Biol Phys 64 2006 1255 1264
14. S. Gianolini, L. Widesott, T. Rancati, E.D. Martin, C. Bianchi, and A. Monti Does the shape of the rectal surface dose distribution predict the risk of late rectal incontinence and bleeding, in patients treated with high-dose 3DCRT for localized prostate cancer? Radiother Oncol 88 2008 S320
15. M.R. Sydes, R.J. Stephens, A.R. Moore, E.G. Aird, A.M. Bidmead, and L.J. Fallowfield Implementing the UK Medical Research Council (MRC)RT01 trial (ISRCTN 47772397): methods and practicalities of a randomised controlled trial of conformal radiotherapy in men with localised prostate cancer Radiother Oncol 72 2004 199 211
16. D.P. Dearnaley, M.R. Sydes, J.D. Graham, E.G. Aird, D. Bottomley, and R.A. Cowan Escalated-dose versus standard-dose conformal radiotherapy in prostate cancer: first results from the MRC RT01 randomised controlled trial Lancet Oncol 8 2007 475 487
17. S.L. Gulliford, K. Foo, R.C. Morgan, E.G. Aird, A.M. Bidmead, and H. Critchley Dose-volume constraints to reduce rectal side effects from prostate radiotherapy: evidence from the MRC RT01 trial ISRCTN 47772397 Int J Radiat Oncol Biol Phys 76 2010 747 754
18. S.A. Mangar, M.R. Sydes, H.L. Tucker, J. Coffey, S.A. Sohaib, and S. Gianolini Evaluating the relationship between erectile dysfunction and dose received by the penile bulb: using data from a randomised controlled trial of conformal radiotherapy in prostate cancer (MRC RT01, ISRCTN47772397) Radiother Oncol 80 2006 355 362
19. F. Buettner, S.L. Gulliford, S. Webb, M.R. Sydes, D.P. Dearnaley, and M. Partridge Assessing correlations between the spatial distribution of the dose to the rectal wall and late rectal toxicity after prostate radiotherapy: an analysis of data from the MRC RT01 trial (ISRCTN 47772397) Phys Med Biol 54 2009 6535 6548
20. K.K. Agarwal, A.K. Agarwal, and P.J. Singh Comparative study of anorectal region in mammals J Anat Soc India 51 2005 220 224
21. D. Vordermark, M. Sailer, M. Flentje, A. Thiede, and O. Kolbl Curative-intent radiation therapy in anal carcinoma: quality of life and sphincter function Radiother Oncol 52 1999 239 243
22. G.J. Meijer, M. van den Brink, M.S. Hoogeman, J. Meinders, and J.V. Lebesque Dose-wall histograms and normalized dose-surface histograms for the rectum: a new method to analyze the dose distribution over the rectum in conformal radiotherapy Int J Radiat Oncol Biol Phys 45 1999 1073 1080
23. B. Sanchez-Nieto, J.F. Fenwick, A.E. Nahum, and D.P. Dearnaley Biological dose surface maps: evaluation of 3D dose data for tubular organs Radiother Oncol 61 2001 52
24. J. Booth, and S. Zavgorodni Modelling the variation in rectal dose due to inter-fraction rectal wall deformation in external beam prostate treatments Phys Med Biol 50 2005 5055 5074
25. M.S. Hoogeman, P.C.M. Koper, and W.D. Heemsbergen Correlation of 3D dose distribution and rectal complications after prostate treatment Radiother Oncol 64 2002 71
26. M.S. Hoogeman, M. van Herk, J. de Bois, and J.V. Lebesque Strategies to reduce the systematic error due to tumor and rectum motion in radiotherapy of prostate cancer Radiother Oncol 74 2005 177 185
27. E.N.J.T. van Lin, J. Kristinsson, M.E.P. Philippens, D.J. de Jong, L.P. van der Vight, and J.H.A.M. Kaanders Reduced late rectal mucosal changes after prostate three-dimensional conformal radiotherapy with endorectal balloon as observed in repeated endoscopy Int J Radiat Oncol Biol Phys 67 2007 799 811
28. P.H. Westfall, and S.S. Young Resampling-Based Multiple Testing: Examples and Methods for p-Value Adjustment 1993 Wiley New York
29. T. Hothorn, K. Hornik, M.A. van de Wiel, and A. Zeileis Implementing a class of permutation tests: the coin package J Stat Softw 28 2008 1 23
30. R. Munbodh, A. Jackson, J. Bauer, C.R. Schmidtlein, and M.J. Zelefsky Dosimetric and anatomic indicators of late rectal toxicity after high-dose intensity modulated radiation therapy for prostate cancer Med Phys 35 2008 2137 2150
31. J.D. Fenwick Impact of dose-distribution uncertainties on rectal NTCP modeling: II. Uncertainty implications Med Phys 28 2001 570 581
32. T. Rancati, C. Fiorino, G. Fellin, V. Vavassori, E. Cagna, and V.C. Borca Inclusion of clinical risk factors into NTCP modelling of late rectal toxicity after high dose radiotherapy for prostate cancer Radiother Oncol 100 2011 124 130
33. G. Defraene, L.V. den Bergh, A. Al-Mamgani, K. Haustermans, W. Heemsbergen, and F.V. den Heuvel The benefits of including clinical factors in rectal normal tissue complication probability modeling after radiotherapy for prostate cancer Int J Radiat Oncol Biol Phys 82 2012 1233 1242