Gastrointestinal toxicity and its relation to dose distributions in the anorectal region of prostate cancer patients treated with radiotherapy

International Journal of Radiation Oncology Biology Physics

Volumn 61, Issue 4, 2005, Pages 1011-1018

  Heemsbergen, Wilma D ^a   Hoogeman, Mischa S ^a   Hart, Guus A M ^a   Lebesque, Joos V ^a   Koper, Peter C M ^b  

^a ANTONI VAN LEEUWENHOEK HOSPITAL   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

Dose effect relation; GI toxicity; Prostate cancer; Radiotherapy

Indexed keywords

DATA ACQUISITION; DOSIMETRY; MATHEMATICAL MODELS; PATIENT TREATMENT; REGRESSION ANALYSIS; TUMORS;

CLINICAL PARAMETERS; DOSE DISTRIBUTIONS; DOSE-AREA PARAMETERS; GI SYMPTOMS; SOILING;

TOXICITY;

ABDOMINAL CRAMP; ABDOMINAL PAIN; AGED; ANUS; ARTICLE; CANCER LOCALIZATION; CANCER RADIOTHERAPY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; DIARRHEA; DISEASE ASSOCIATION; DOSIMETRY; FECES INCONTINENCE; GASTROINTESTINAL SYMPTOM; GASTROINTESTINAL TOXICITY; HEALTH HAZARD; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROSTATE CARCINOMA; QUESTIONNAIRE; RADIATION DOSE DISTRIBUTION; RADIATION FIELD; RANDOMIZED CONTROLLED TRIAL; RECTUM; RECTUM HEMORRHAGE; RECTUM MUCOSA; REGRESSION ANALYSIS; STATISTICAL SIGNIFICANCE; URGE INCONTINENCE;

ANALYSIS OF VARIANCE; COLIC; DEFECATION; DIARRHEA; DOSE-RESPONSE RELATIONSHIP, RADIATION; FECAL INCONTINENCE; GASTROINTESTINAL DISEASES; GASTROINTESTINAL HEMORRHAGE; HUMANS; MALE; PROPORTIONAL HAZARDS MODELS; PROSTATIC NEOPLASMS; RADIATION INJURIES; RECTUM;

EID: 14844302796     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2004.07.724     Document Type: Article

References (24)

1. J. Cox, J. Stetz, T.F. Pajak Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Cancer Research and Treatment of Cancer (EORTC) Int J Radiat Oncol Biol Phys 31 1995 1341 1346
2. L.J. Boersma, M. van den Brink, A.M. Bruce Estimation of the incidence of late bladder and rectum complications after high-dose (70-78 Gy) conformal radiotherapy for prostate cancer, using dose-volume histograms Int J Radiat Oncol Biol Phys 41 1998 83 92
3. C. Fiorino, C. Cozzarini, V. Vavassori Relationships between DVHs and later rectal bleeding after radiotherapy for prostate cancer: Analysis of a large group of patients pooled from three institutions Radiother Oncol 64 2002 1 12
4. C. Fiorino, G. Sanguineti, C. Cozzarini Rectal dose-volume constraints in high-dose radiotherapy of localized prostate cancer Int J Radiat Oncol Biol Phys 57 2003 953 962
5. M.W. Skwarchuk, A. Jackson, M.J. Zelefsky Late rectal toxicity after conformal radiotherapy of prostate cancer (I): Multivariate analysis and dose-response Int J Radiat Oncol Biol Phys 47 2000 103 113
6. A. Jackson, M.W. Skwarchuk, J. Zelefsky Late rectal bleeding after conformal radiotherapy of prostate cancer (II): Volume effects and dose-volume histograms Int J Radiat Oncol Biol Phys 49 2001 685 698
7. C. Greco, C. Mazzetta, F. Cattani Finding dose-volume constraints to reduce late rectal toxicity following 3D-conformal radiotherapy (3D-CRT) of prostate cancer Radiother Oncol 69 2003 215 222
8. S. Wachter, N. Gerstner, G. Goldner Rectal sequelae after conformal radiotherapy of prostate cancer: Dose-volume histograms as predictive factors Radiother Oncol 59 2001 65 70
9. P.C. Koper, W.D. Heemsbergen, M.S. Hoogeman Impact of volume and location of irradiated rectum wall on rectal blood loss after radiotherapy of prostate cancer Int J Radiat Oncol Biol Phys 58 2004 1072 1082
10. E.H. Huang, A. Pollack, L. Levy Late rectal toxicity: Dose-volume effects of conformal radiotherapy for prostate cancer Int J Radiat Oncol Biol Phys 54 2002 1314 1321
11. C. Vargas, L.L. Kestin, D. Yan Dose-volume analysis of predictors for chronic rectal toxicity following treatment of prostate cancer with high-dose conformal radiotherapy Int J Radiat Oncol Biol Phys 57 Suppl. 2003 S398 S399
12. J.D. Fenwick, V.S. Khoo, A.E. Nahum Correlations between dose-surface histograms and the incidence of long-term rectal bleeding following conformal or conventional radiotherapy treatment of prostate cancer Int J Radiat Oncol Biol Phys 49 2001 473 480
13. M.S. Hoogeman, M. van Herk, J. de Bois Quantification of local rectal wall displacements by virtual rectum unfolding Radiother Oncol 70 2004 21 30
14. P.C. Koper, J.C. Stroom, W.L. van Putten Acute morbidity reduction using 3DCRT for prostate carcinoma: A randomized study Int J Radiat Oncol Biol Phys 43 1999 727 734
15. D.M. Tait, A.E. Nahum, L.C. Meyer Acute toxicity in pelvic radiotherapy: Randomized trial of conformal versus conventional treatment Radiother Oncol 42 1997 121 136
16. G. Goldner, N. Wachter-Gerstner, S. Wachter Acute side effects during 3-D-planned conformal radiotherapy of prostate cancer Stralenther Onkol 179 2003 320 327
17. G.J. Meijer, M. van den Brink, M.S. Hoogeman Dose-wall histograms and normalized dose-surface histograms for the rectum: A new method to analyze the dose distribution over the rectum in conformal radiotherapy Int J Radiat Oncol Biol Phys 45 1999 1073 1080
18. D. Collett Modelling survival data in medical research 1994 Chapman & Hall London p. 243-246
19. E. Dale, D.R. Olsen, S.D. Fossa Normal tissue complication probabilities correlated with late effects in the rectum after prostate conformal radiotherapy Int J Radiat Oncol Biol Phys 43 1999 385 391
20. E.E.K. Yeoh, R. Botten, A. Russo Chronic effects of therapeutic irradiation for localized prostate carcinoma on anorectal function Int J Radiat Oncol Biol Phys 47 2000 915 924
21. J.S. Varma, A.N. Smith, A. Busuttil Function of the anal sphincters after chronic radiation injury Gut 27 1986 528 533
22. I. Berndtsson, B. Lennernas, L. Hulten Anorectal function after modern conformal radiation therapy for prostate cancer: A pilot study Tech Coloproctol 6 2002 101 104
23. D. Hayne, C.J. Vaizey, P.B. Boulos Anorectal injury following pelvic radiotherapy Br J Surg 88 2001 1037 1048
24. D. Vordermark, M. Schwab, R. Ness-Dourdoumas Association of anorectal dose-volume histograms and impaired fecal continence after 3D conformal radiotherapy for carcinoma of the prostate Radiother Oncol 69 2003 209 214