Intravenous immunoglobulin does not increase FcγRIIB expression levels on monocytes in children with immune thrombocytopenia

Clinical and Experimental Immunology

Volumn 169, Issue 1, 2012, Pages 33-37

  Shimomura, M ^a   Hasegawa, S ^a   Seki, Y ^a   Fukano, R ^a   Hotta, N ^a   Ichiyama, T ^a  

^a YAMAGUCHI UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Fc RIIB; Immune thrombocytopenia; Intravenous immunoglobulin; Monocytes

Indexed keywords

CD14 ANTIGEN; FC RECEPTOR IIB; IMMUNOGLOBULIN;

ARTICLE; CHILD; CLINICAL ARTICLE; DRUG INDICATION; FEMALE; FLOW CYTOMETRY; HUMAN; IDIOPATHIC THROMBOCYTOPENIC PURPURA; IMMUNOTHERAPY; INFANT; MALE; MONOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ACUTE DISEASE; ANIMALS; ANTIGENS, CD14; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; FEMALE; FLOW CYTOMETRY; GPI-LINKED PROTEINS; HUMANS; IMMUNOGLOBULINS, INTRAVENOUS; INFANT; MACROPHAGES; MALE; MICE; MONOCYTES; PLATELET COUNT; RECEPTORS, IGG; THROMBOCYTOPENIA;

EID: 84861732261     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2012.04591.x     Document Type: Article

References (24)

1. Harrington WJ, Minnich V, Hollingsworth JW etal. Demonstration of a thrombocytopenic factor in the blood of patients with thrombocytopenic peupura. J Lab Clin Med 1951; 38:1-10.
2. Hansen RJ, Balthasar JP. Mechanisms of IVIG action in immune thrombocytopenic purpura. Clin Lab 2004; 50:133-40.
3. Crow AR, Song S, Siragam V etal. Mechanism of action of intravenous immunoglobulin in the treatment of immune thrombocytopenia. Pediatr Blood Cancer 2006; 47:710-3.
4. Psaila B, Bussel JB. Fc receptors in immune thrombocytopenias: a target for immunomodulation? J Clin Invest 2008; 118:2677-81.
5. Imbach P, Barandun S, Baumgartner C etal. High-dose intravenous gammaglobulin for idiopathic thrombocytopenic purpura in childhood. Lancet 1981; 1:1228-31.
6. Bussel JB. Another interaction of the FcR system with IVIG. Thromb Haemost 2002; 88:890-1.
7. Crow AR, Song S, Freedman J etal. IVIg-mediated amelioration of murine ITP via FcgammaRIIB is independent of SHIP 1, SHP-1, and Btk activity. Blood 2003; 102:558-60.
8. Samuelsson A, Towers TL, Ravetch JV. Anti-inflammatory activity of IVIG mediated through the inhibitory Fc receptor. Science 2001; 291:484-6.
9. Li M, Wirthmueller U, Ravetch JV. Reconstitution of human Fc gamma RIII cell type specificity in transgenic mice. J Exp Med 1996; 183:1259-63.
10. George JN, Woolf SH, Raskob GE etal. Idiopathic thrombocytopenic purpura: a practice guideline developed by explicit methods for the American Society of Hematology. Blood 1996; 88:1-30.
11. Brooks DG, Qiu WQ, Luster AD etal. Structure and expression of human IgG FcRII(CD32). Functional heterogeneity is encoded by the alternatively spliced products of multiple genes. J Exp Med 1989; 170:1369-85.
12. Warmerdam PA, Nabben NM, van de Graaf SA etal. The human low affinity immunoglobulin G Fc receptor IIC gene is a result of an unequal crossover event. J Biol Chem 1993; 268:7346-9.
13. Ravetch JV, Bolland S. IgG Fc receptor. Annu Rev Immunol 2001; 19:275-90.
14. Van de Winkel JG, Anderson CL. Biology of human immunoglobulin G Fc receptors. J Leukoc Biol 1991; 49:511-24.
15. van de Winkel JG, Capel PJ. Human IgG Fc receptor heterogeneity: molecular aspects and clinical implications. Immunol Today 1993; 14:215-21.
16. Ravetch JV, Lanier LL. Immune inhibitory receptors. Science 2000; 290:84-9.
17. Daeron M, Malbec O, Latour S etal. Regulation of high-affinity IgE receptor-mediated mast cell activation by murine low-affinity IgG receptors. J Clin Invest 1995; 95:577-85.
18. Ono M, Bolland S, Tempst P etal. Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor Fc(gamma)RIIB. Nature 1996; 383:263-6.
19. Malbeco O, Fong DC, Turmer M etal. Fc epsilon receptor I-associated lyn-dependent phosphorylation of Fc gamma receptor IIB during negative regulation of mast cell activation. J Immunol 1998; 160:1647-58.
20. Clynes R, Maizes JS, Guinamard R etal. Modulation of immune complex-induced inflammation in vivo by the coordinate expression of activation and inhibitory Fc receptors. J Exp Med 1999; 189:179-85.
21. Crow AR, Song S, Freedman J etal. IVIg-mediated amelioration of murine ITP via FcgammaRIIB is independent of SHIP1, SHP-1, and Btk activity. Blood 2003; 102:558-60.
22. Jin F, Balthasar JP. Mechanism of intravenous immunoglobulin action in immuno thrombocytopenic purpura. Hum Immunol 2005; 66:403-10.
23. Tovo PA, Miniero R, Fiandino G etal. Fc-depleted vs intact intravenous immunoglobulin in chronic ITP. J Pediatr 1984; 105:676-7.
24. Machino Y, Ohta H, Suzuki E etal. Effect of immunoglobulin G (IgG) interchain disulfide bond cleavage on efficacy of intravenous immunoglobulin for immune thrombocytopenic purpura (ITP). Clin Exp Immunol 2010; 162:415-24.