Mechanisms of intravenous immunoglobulin action in immune thrombocytopenic purpura

Human Immunology

Volumn 66, Issue 4, 2005, Pages 403-410

  Jin, Feng ^a   Balthasar, Joseph P ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

Autoimmune disease; Immune thrombocytopenic purpura; Intravenous immunoglobulin

Indexed keywords

FC RECEPTOR; IMMUNOGLOBULIN; IMMUNOGLOBULIN G; THROMBOCYTE ANTIBODY;

AUTOIMMUNE DISEASE; CLINICAL TRIAL; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG MEGADOSE; HUMAN; IDIOPATHIC THROMBOCYTOPENIC PURPURA; IMMUNE RESPONSE; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOGLOBULIN PRODUCTION; IMMUNOMODULATION; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; THROMBOCYTE COUNT; TREATMENT OUTCOME;

EID: 18144377058     PISSN: 01988859     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humimm.2005.01.029     Document Type: Article

References (58)

1. J.N. George, S.H. Woolf, G.E. Raskob, J.S. Wasser, L.M. Aledort, P.J. Ballem, V.S. Blanchette, J.B. Bussel, D.B. Cines, J.G. Kelton, A.E. Lichtin, R. McMillan, J.A. Okerbloom, D.H. Regan, I. Warrier Idiopathic thrombocytopenic purpura a practice guideline developed by explicit methods for the American Society of Hematology Blood 88 1996 3
2. W.J. Harrington, V. Minnich, J.W. Hollingsworth, C.V. Moore Demonstration of a thrombocytopenic factor in the blood of patients with thrombocytopenic purpura J Lab Clin Med 38 1951 1
3. R.J. Hansen, J.P. Balthasar Mechanisms of IVIG action in immune thrombocytopenic purpura Clin Lab 50 2004 133
4. E.F. van Leeuwen, J.T. van der Ven, C.P. Engelfriet, A.E. von dem Borne Specificity of autoantibodies in autoimmune thrombocytopenia Blood 59 1982 23
5. V.L. Woods Jr, Y. Kurata, R.R. Montgomery, P. Tani, D. Mason, E.H. Oh, R. McMillan Autoantibodies against platelet glycoprotein Ib in patients with chronic immune thrombocytopenic purpura Blood 64 1984 156
6. K. Fujisawa, P. Tani, R. McMillan Platelet-associated antibody to glycoprotein IIb/IIIa from chronic immune thrombocytopenic purpura patients often binds to divalent cation-dependent antigens Blood 81 1993 1284
7. M. Hou, D. Stockelberg, J. Kutti, H. Wadenvik Immunoglobulins targeting both GPIIb/IIIa and GPIb/IX in chronic idiopathic thrombocytopenic purpura (ITP) evidence for at least two different IgG antibodies Br J Haematol 98 1997 64
8. P. Imbach, S. Barandun, V. d'Apuzzo, C. Baumgartner, A. Hirt, A. Morell, E. Rossi, M. Schoni, M. Vest, H.P. Wagner High-dose intravenous gammaglobulin for idiopathic thrombocytopenic purpura in childhood Lancet 1 1981 1228
9. A.C. Newland, J.G. Treleaven, R.M. Minchinton, A.H. Waters High-dose intravenous IgG in adults with autoimmune thrombocytopenia Lancet 1 1983 84
10. J.B. Bussel, R.P. Kimberly, R.D. Inman, I. Schulman, C. Cunningham-Rundles, N. Cheung, E.M. Smithwick, J. O'Malley, S. Barandun, M.W. Hilgartner Intravenous gammaglobulin treatment of chronic idiopathic thrombocytopenic purpura Blood 62 1983 480
11. P. Imbach, H.P. Wagner, W. Berchtold, G. Gaedicke, A. Hirt, P. Joller, C. Mueller-Eckhardt, B. Muller, E. Rossi, S. Barandun Intravenous immunoglobulin versus oral corticosteroids in acute immune thrombocytopenic purpura in childhood Lancet 2 1985 464
12. V.S. Blanchette, M.A. Kirby, C. Turner Role of intravenous immunoglobulin G in autoimmune hematologic disorders Semin Hematol 29 3 Suppl 2 1992 72
13. E. Arsura Experience with intravenous immunoglobulin in myasthenia gravis Clin Immunol Immunopathol 53 1989 S170 (2 Pt 2)
14. I. Lundkvist, P.A. van Doorn, M. Vermeulen, M. van Lint, J.J. van Rood, A. Brand Regulation of autoantibodies in inflammatory demyelinating polyneuropathy spontaneous and therapeutic Immunol Rev 110 1989 105
15. S.C. Jordan Intravenous gamma-globulin therapy in systemic lupus erythematosus and immune complex disease Clin Immunol Immunopathol 53 1989 S164 (2 Pt 2)
16. D.R. Jayne, M.J. Davies, C.J. Fox, C.M. Black, C.M. Lockwood Treatment of systemic vasculitis with pooled intravenous immunoglobulin Lancet 337 8750 1991 1137
17. J.W. Newburger, M. Takahashi, J.C. Burns, A.S. Beiser, K.J. Chung, C.E. Duffy, M.P. Glode, W.H. Mason, V. Reddy, S.P. Sanders The treatment of Kawasaki syndrome with intravenous gamma globulin N Engl J Med 315 1986 341
18. Y.S. Mehta, S.S. Badakere In-vitro inhibition of antiplatelet autoantibodies by intravenous immunoglobulins and Rh immunoglobulins J Postgrad Med 42 1996 46
19. P. Berchtold, G.L. Dale, P. Tani, R. McMillan Inhibition of autoantibody binding to platelet glycoprotein IIb/IIIa by anti-idiotypic antibodies in intravenous gammaglobulin Blood 74 1989 2414
20. Y. Sultan, M.D. Kazatchkine, P. Maisonneuve, U.E. Nydegger Anti-idiotypic suppression of autoantibodies to factor VIII (antihaemophilic factor) by high-dose intravenous gammaglobulin Lancet 2 1984 765
21. J.B. Bussel Another interaction of the FcR system with IVIG Thromb Haemost 88 2002 890
22. M. Ballow Mechanisms of action of intravenous immune serum globulin in autoimmune and inflammatory diseases J Allergy Clin Immunol 100 1997 151
23. W.A. Sewell, S. Jolles Immunomodulatory action of intravenous immunoglobulin Immunology 107 2002 387
24. Z. Yu, V.A. Lennon Mechanism of intravenous immune globulin therapy in antibody-mediated autoimmune diseases N Engl J Med 340 1999 227
25. J.V. Ravetch, S. Bolland IgG Fc receptors Annu Rev Immunol 19 2001 275
26. S.G. Ericson, K.D. Coleman, K. Wardwell, S. Baker, M.W. Fanger, P.M. Guyre, P. Ely Monoclonal antibody 197 (anti-Fc gamma RI) infusion in a patient with immune thrombocytopenia purpura (ITP) results in down-modulation of Fc gamma RI on circulating monocytes Br J Haematol 92 1996 718
27. B.K. Flesch, G. Achtert, J. Neppert Inhibition of monocyte and polymorphonuclear granulocyte immune phagocytosis by monoclonal antibodies specific for Fc gamma RI, II and III Ann Hematol 74 1997 15
28. S.B. Clarkson, J.B. Bussel, R.P. Kimberly, J.E. Valinsky, R.L. Nachman, J.C. Unkeless Treatment of refractory immune thrombocytopenic purpura with an anti-Fc gamma-receptor antibody N Engl J Med 314 1986 1236
29. J. Fehr, V. Hofmann, U. Kappeler Transient reversal of thrombocytopenia in idiopathic thrombocytopenic purpura by high-dose intravenous gamma globulin N Engl J Med 306 1982 1254
30. A. Salama, C. Mueller-Eckhardt, V. Kiefel Effect of intravenous immunoglobulin in immune thrombocytopenia Lancet 2 1983 193
31. R.E. Ware, S.A. Zimmerman Anti-D mechanisms of action Semin Hematol 35 1998 14 (1 Suppl 1)
32. J.L. Teeling, T. Jansen-Hendriks, T.W. Kuijpers, M. de Haas, J.G. van de Winkel, C.E. Hack, W.K. Bleeker Therapeutic efficacy of intravenous immunoglobulin preparations depends on the immunoglobulin G dimers studies in experimental immune thrombocytopenia Blood 98 2001 1095
33. R. Bazin, R. Lemieux, T. Tremblay, I. St-Amour Tetramolecular immune complexes are more efficient than IVIg to prevent antibody-dependent in vitro and in vivo phagocytosis of blood cells Br J Haematol 127 2004 90
34. A. Samuelsson, T.L. Towers, J.V. Ravetch Anti-inflammatory activity of IVIG mediated through the inhibitory Fc receptor Science 291 5503 2001 484
35. S. Akilesh, S. Petkova, T.J. Sproule, D.J. Shaffer, G.J. Christianson, D. Roopenian The MHC class I-like Fc receptor promotes humorally mediated autoimmune disease J Clin Invest 113 2004 1328
36. T. Ichiyama, Y. Ueno, M. Hasegawa, Y. Ishikawa, T. Matsubara, S. Furukawa Intravenous immunoglobulin does not increase FcγRIIB expression on monocytes/macrophages during acute Kawasaki disease Rheumatology 44 2004 314 (Oxford)
37. P.A. Tovo, R. Miniero, G. Fiandino, P. Saracco, M. Messina Fc-depleted vs intact intravenous immunoglobulin in chronic ITP J Pediatr 105 1984 676
38. M.C. Dalakas, M. Fujii, M. Li, B. Lutfi, J. Kyhos, B. McElroy High-dose intravenous immune globulin for stiff-person syndrome N Engl J Med 345 2001 1870
39. A. Fateh-Moghadam, M. Wick, U. Besinger, R.G. Geursen High-dose intravenous gammaglobulin for myasthenia gravis Lancet 1 8381 1984 848
40. B. Ferrero, L. Durelli, R. Cavallo, A. Dutto, G. Aimo, F. Pecchio, B. Bergamasco Therapies for exacerbation of myasthenia gravis the mechanism of action of intravenous high-dose immunoglobulin G Ann N Y Acad Sci 681 1993 563
41. D.R. Jayne, V.L. Esnault, C.M. Lockwood ANCA anti-idiotype antibodies and the treatment of systemic vasculitis with intravenous immunoglobulin J Autoimmun 6 1993 207
42. L. Hammarstrom, M.R. Abedi, M.S. Hassan, C.I. Smith The SCID mouse as a model for autoimmunity J Autoimmun 6 1993 667
43. Y. Sultan, F. Rossi, M.D. Kazatchkine Recovery from anti-VIII:C (antihemophilic factor) autoimmune disease is dependent on generation of antiidiotypes against anti-VIII:C autoantibodies Proc Natl Acad Sci U S A 84 1987 828
44. A.R. Crow, S. Song, J.W. Semple, J. Freedman, A.H. Lazarus IVIg inhibits reticuloendothelial system function and ameliorates murine passive-immune thrombocytopenia independent of anti-idiotype reactivity Br J Haematol 115 2001 679
45. R.J. Hansen, J.P. Balthasar Effects of intravenous immunoglobulin on platelet count and antiplatelet antibody disposition in a rat model of immune thrombocytopenia Blood 100 2002 2087
46. P.L. Masson Elimination of infectious antigens and increase of IgG catabolism as possible modes of action of IVIg J Autoimmun 6 1993 683
47. R.J. Hansen, J.P. Balthasar Intravenous immunoglobulin mediates an increase in anti-platelet antibody clearance via the FcRn receptor Thromb Haemost 88 2002 898
48. W.K. Bleeker, J.L. Teeling, C.E. Hack Accelerated autoantibody clearance by intravenous immunoglobulin therapy studies in experimental models to determine the magnitude and time course of the effect Blood 98 2001 3136
49. E.D. Lobo, R.J. Hansen, J.P. Balthasar Antibody pharmacokinetics and pharmacodynamics J Pharm Sci 93 2004 2645
50. F.W. Brambell, W.A. Hemmings, I.G. Morris A theoretical model of gamma-globulin catabolism Nature 203 1964 1352
51. E.A. Jones, T.A. Waldmann The mechanism of intestinal uptake and transcellular transport of IgG in the neonatal rat J Clin Invest 51 1972 2916
52. N.E. Simister, K.E. Mostov An Fc receptor structurally related to MHC class I antigens Nature 337 6203 1989 184
53. E.J. Israel, D.F. Wilsker, K.C. Hayes, D. Schoenfeld, N.E. Simister Increased clearance of IgG in mice that lack beta 2-microglobulin possible protective role of FcRn Immunology 89 1996 573
54. R.P. Junghans, C.L. Anderson The protection receptor for IgG catabolism is the beta2-microglobulin-containing neonatal intestinal transport receptor Proc Natl Acad Sci U S A 93 1996 5512
55. V. Ghetie, J.G. Hubbard, J.K. Kim, M.F. Tsen, Y. Lee, E.S. Ward Abnormally short serum half-lives of IgG in beta 2-microglobulin-deficient mice Eur J Immunol 26 1996 690
56. R.J. Hansen, J.P. Balthasar Pharmacokinetic/pharmacodynamic modeling of the effects of intravenous immunoglobulin on the disposition of antiplatelet antibodies in a rat model of immune thrombocytopenia J Pharm Sci 92 2003 1206
57. B. Imholz, P. Imbach, C. Baumgartner, W. Berchtold, G. Gaedicke, E. Gugler, A. Hirt, W. Hitzig, C. Mueller-Eckhardt, H.P. Wagner Intravenous immunoglobulin (i.v. IgG) for previously treated acute or for chronic idiopathic thrombocytopenic purpura (ITP) in childhood a prospective multicenter study Blut 56 1988 63
58. T.A. Waldmann, W. Strober Metabolism of immunoglobulins Prog Allergy 13 1969 1