Disease phenotype in sheep after infection with cloned murine scrapie strains

Prion

Volumn 6, Issue 2, 2012, Pages 174-183

  Sisó, Sílvia ^a,d   Chianini, Francesca ^b   Eaton, Sam L ^b   Witz, Janey ^a   Hamilton, Scott ^b   Martin, Stuart ^a   Finlayson, Jeanie ^b   Pang, Yvonne ^b   Stewart, Paula ^c   Steele, Philip ^b   Dagleish, Mark P ^b   Goldmann, Wilfred ^c   Reid, Hugh W ^b   Jeffrey, Martin ^a   González, Lorenzo ^a  

^a VETERINARY LABORATORIES AGENCY   (United Kingdom)

^b MOREDUN RESEARCH INSTITUTE   (United Kingdom)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Biological properties; Interspecies transmission; Prion protein; Scrapie diversity; Species barrier; Strain typing

Indexed keywords

PRION PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; BIOASSAY; BREEDING; CHEMICAL ANALYSIS; CONFERENCE PAPER; CONTROLLED STUDY; GENETIC SUSCEPTIBILITY; GENOTYPE; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INCUBATION TIME; MOUSE; MOUSE STRAIN; MURINE SCRAPIE VIRUS; NONHUMAN; PHENOTYPE; RODENT; SCRAPIE; SCRAPIE AGENT; SHEEP; SPECIES COMPARISON; VIRUS GENE; VIRUS ISOLATION; VIRUS STRAIN; VIRUS TRANSMISSION;

ADMINISTRATION, ORAL; ANIMALS; BRAIN CHEMISTRY; EPITOPE MAPPING; GLYCOPROTEINS; GLYCOSYLATION; IMMUNOHISTOCHEMISTRY; MICE; MICE, INBRED C57BL; ORGAN SPECIFICITY; PHENOTYPE; PRIONS; PROTEIN ISOFORMS; SCRAPIE; SHEEP; SPECIES SPECIFICITY; VAGUS NERVE;

MURINAE; MUS; OVIS ARIES; RODENTIA;

EID: 84861730516     PISSN: 19336896     EISSN: 1933690X     Source Type: Journal    
DOI: 10.4161/pri.18990     Document Type: Conference Paper

References (42)

1. Prusiner SB, Bolton DC, Groth DF, Bowman KA, Cochran SP, McKinley MP. Further purification and characterization of scrapie prions. Biochemistry 1982; 21:6942-50; PMID:6818988; http://dx.doi.org/10.1021/bi00269a050.
2. Sisó S, González L, Blanco R, Chianini F, Reid HW, Jeffrey M, et al. Neuropathological changes correlate temporally but not spatially with selected neuromodulatory responses in natural scrapie. Neuropathol Appl Neurobiol 2011; 37:484-99; PMID:21114681; http://dx.doi.org/10.1111/j.1365-2990. 2010.01152.x.
3. González L, Martin S, Jeffrey M. Distinct profiles of PrP(d) immunoreactivity in the brain of scrapieand BSE-infected sheep: implications for differential cell targeting and PrP processing. J Gen Virol 2003; 84:1339-50; PMID:12692301; http://dx.doi.org/10.1099/vir.0.18800-0.
4. González L, Martin S, Houston FE, Hunter N, Reid HW, Bellworthy SJ, et al. Phenotype of disease-associated PrP accumulation in the brain of bovine spongiform encephalopathy experimentally infected sheep. J Gen Virol 2005; 86:827-38; PMID:15722546; http://dx.doi.org/10.1099/vir.0.80299-0.
5. González L, Martin S, Begara-McGorum I, Hunter N, Houston F, Simmons M, et al. Effects of agent strain and host genotype on PrP accumulation in the brain of sheep naturally and experimentally affected with scrapie. J Comp Pathol 2002; 126:17-29; PMID:11814318; http://dx.doi.org/10.1053/jcpa.2001. 0516.
6. Sisó S, Jeffrey M, Martin S, Chianini F, Dagleish MP, González L. Characterization of strains of ovine transmissible spongiform encephalopathy with a short PrPd profiling method. J Comp Pathol 2010; 142:300-10; PMID:20153480; http://dx.doi.org/10.1016/j.jcpa.2009.12.003.
7. Ligios C, Jeffrey M, Ryder SJ, Bellworthy SJ, Simmons MM. Distinction of scrapie phenotypes in sheep by lesion profiling. J Comp Pathol 2002; 127:45-57; PMID:12354545; http://dx.doi.org/10.1053/jcpa.2002.0589.
8. Spiropoulos J, Casalone C, Caramelli M, Simmons MM. Immunohistochemistry for PrPSc in natural scrapie reveals patterns which are associated with the PrP genotype. Neuropathol Appl Neurobiol 2007; 33:398-409; PMID:17617872; http://dx.doi.org/10.1111/j.1365-2990.2007.00800.x.
9. Ersdal C, Ulvund MJ, Espenes A, Benestad SL, Sarradin P, Landsverk T. Mapping PrPSc propagation in experimental and natural scrapie in sheep with different PrP genotypes. Vet Pathol 2005; 42:258-74; PMID:15872372; http://dx.doi.org/10.1354/vp.42-3-258.
10. Begara-McGorum I, González L, Simmons M, Hunter N, Houston F, Jeffrey M. Vacuolar lesion profile in sheep scrapie: factors influencing its variation and relationship to disease-specific PrP accumulation. J Comp Pathol 2002; 127:59-68; PMID:12354546; http://dx.doi.org/10.1053/jcpa.2002.0558.
11. Jeffrey M, Martin S, González L, Ryder SJ, Bellworthy SJ, Jackman R. Differential diagnosis of infections with the bovine spongiform encephalopathy (BSE) and scrapie agents in sheep. J Comp Pathol 2001; 125:271-84; PMID:11798244; http://dx.doi.org/10.1053/jcpa.2001.0499.
12. González L, Sisó S, Monleón E, Casalone C, van Keulen LJ, Balkema-Buschmann A, et al. Variability in disease phenotypes within a single PRNP genotype suggests the existence of multiple natural sheep scrapie strains within Europe. J Gen Virol 2010; 91:2630-41; PMID:20538906; http://dx.doi.org/10.1099/vir.0.022574-0.
13. Jeffrey M, González L, Chong A, Foster J, Goldmann W, Hunter N, et al. Ovine infection with the agents of scrapie (CH1641 isolate) and bovine spongiform encephalopathy: immunochemical similarities can be resolved by immunohistochemistry. J Comp Pathol 2006; 134:17-29; PMID:16324707; http://dx.doi.org/10.1016/j.jcpa.2005.06.005.
14. Dickinson AG. Scrapie in sheep and goats. In: Kimberlin RH, Ed. Slow Virus Diseases of Animals and Man. Amsterdam, North-Holland 1976; 209-39.
15. Kimberlin RH. Early events in the pathogenesis of scrapie in mice: biological and biochemical studies. In: Prusiner SB and Hadlow WJ. Slow Transmissible Diseases of the Nervous System. New York: Academic Press 1979; 2:33-54.
16. Béringue V, Vilotte JL, Laude H. Prion agent diversity and species barrier. Vet Res 2008; 39:47; PMID:18519020; http://dx.doi.org/10.1051/vetres: 2008024.
17. Bruce ME, McConnell I, Fraser H, Dickinson AG. The disease characteristics of different strains of scrapie in Sinc congenic mouse lines: implications for the nature of the agent and host control of pathogenesis. J Gen Virol 1991; 72:595-603; PMID:1672371; http://dx.doi.org/10.1099/0022-1317-72-3- 595.
18. Fraser H, Dickinson AG. The sequential development of the brain lesion of scrapie in three strains of mice. J Comp Pathol 1968; 78:301-11; PMID:4970192; http://dx.doi.org/10.1016/0021-9975(68)90006-6.
19. Fraser H, Dickinson AG. Scrapie in mice. Agent-strain differences in the distribution and intensity of grey matter vacuolation. J Comp Pathol 1973; 83:29-40; PMID:4199908; http://dx.doi.org/10.1016/0021-9975(73)90024-8.
20. Fraser H. The pathology of natural and experimental scrapie. In: Kimberlin RH, Ed. Slow Virus Diseases of Animals and Man. Amsterdam, North-Holland 1976; 267-303.
21. Bruce ME, Fraser H, McBride PA, Scott JR, Dickinson AG. The basis of strain variation in scrapie. In: Prusiner SB, Collinge J, Powell J and Anderton B, Eds. Prion Diseases of Humans and Animals. Chichester: Ellis Horwood 1992; 497-508.
22. Bruce ME, Will RG, Ironside JW, McConnell I, Drummond D, Suttie A, et al. Transmissions to mice indicate that 'new variant' CJD is caused by the BSE agent. Nature 1997; 389:498-501; PMID:9333239; http://dx.doi.org/10.1038/39057.
23. Bruce ME, Boyle A, Cousens S, McConnell I, Foster J, Goldmann W, et al. Strain characterization of natural sheep scrapie and comparison with BSE. J Gen Virol 2002; 83:695-704; PMID:11842264.
24. Bruce ME. TSE strain variation. Br Med Bull 2003; 66:99-108; PMID:14522852; http://dx.doi.org/10.1093/bmb/66.1.99.
25. Prusiner SB. Novel proteinaceous infectious particles cause scrapie. Science 1982; 216:136-44; PMID:6801762; http://dx.doi.org/10.1126/science. 6801762.
26. Vorberg I, Priola SA. Molecular basis of scrapie strain glycoform variation. J Biol Chem 2002; 277:36775-81; PMID:12138171; http://dx.doi.org/10. 1074/jbc.M206865200.
27. Zlotnik I, Rennie JC. Experimental transmission of mouse passaged scrapie to goats, sheep, rats and hamsters. J Comp Pathol 1965; 75:147-57; PMID:14319384; http://dx.doi.org/10.1016/0021-9975(65)90005-8.
28. Bruce ME, Dickinson AG. Biological stability of different classes of scrapie agent. In: Slow transmissible diseases of the nervous system. Prusiner SB and Hadlow WJ, Eds. London: Academic Press, Inc. 1979; 2:71-86.
29. Outram GW. The pathogenesis of scrapie in mice. In: Kimberlin RH, Ed. Slow Virus Diseases of Animals and Man. Amsterdam, North-Holland 1976; 325-57.
30. Martin S, González L, Chong A, Houston FE, Hunter N, Jeffrey M. Immunohistochemical characteristics of disease-associated PrP are not altered by host genotype or route of inoculation following infection of sheep with bovine spongiform encephalopathy. J Gen Virol 2005; 86:839-48; PMID:15722547; http://dx.doi.org/10.1099/vir.0.80364-0.
31. Dagleish MP, Hamilton S, González L, Eaton SL, Steele P, Finlayson J, et al. Digestion and transportation of bovine spongiform encephalopathy-derived prion protein in the sheep intestine. J Gen Virol 2010; 91:3116-23; PMID:20826616; http://dx.doi.org/10.1099/vir.0.025049-0.
32. Ikeda T, Horiuchi M, Ishiguro N, Muramatsu Y, Kai-Uwe GD, Shinagawa M. Amino acid polymorphisms of PrP with reference to onset of scrapie in Suffolk and Corriedale sheep in Japan. J Gen Virol 1995; 76:2577-81; PMID:7595361; http://dx.doi.org/10.1099/0022-1317-76-10-2577.
33. Laegreid WW, Clawson ML, Heaton MP, Green BT, O'Rourke KI, Knowles DP. Scrapie resistance in ARQ sheep. J Virol 2008; 82:10318-20; PMID:18632863; http://dx.doi.org/10.1128/JVI.00710-08.
34. Kimberlin RH, Cole S, Walker CA. Temporary and permanent modifications to a single strain of mouse scrapie on transmission to rats and hamsters. J Gen Virol 1987; 68:1875-81; PMID:3110370; http://dx.doi.org/10.1099/0022-1317-68-7- 1875.
35. Kimberlin RH, Walker CA, Fraser H. The genomic identity of different strains of mouse scrapie is expressed in hamsters and preserved on reisolation in mice. J Gen Virol 1989; 70:2017-25; PMID:2504883; http://dx.doi.org/10.1099/ 0022-1317-70-8-2017.
36. Scott MR, Groth D, Tatzelt J, Torchia M, Tremblay P, DeArmond SJ, et al. Propagation of prion strains through specific conformers of the prion protein. J Virol 1997; 71:9032-44; PMID:9371560.
37. González L, Nonno R, Chianini F, Goldmann W, Sisó S, Di Bari M, et al. Cross-genotype transmission of scrapie strains results in the emergence of strain variants. Prion 2011; 5:102.
38. Pattison IH, Gordon WS, Millson GC. Experimental production of scrapie in goats. J Comp Pathol 1959; 69:300-12; PMID:14430941.
39. Pattison IH, Millson GC. Scrapie produced experimentally in goats with special reference to the clinical syndrome. J Comp Pathol 1961; 71:101-9; PMID:13733383.
40. Thackray AM, Hopkins L, Lockey R, Spiropoulos J, Bujdoso R. Emergence of multiple prion strains from single isolates of ovine scrapie. J Gen Virol 2011; 92:1482-91; PMID:21270287; http://dx.doi.org/10.1099/vir.0.028886-0.
41. Bruce ME, Dickinson AG, Fraser H. Cerebral amyloidosis in scrapie in the mouse: effect of agent strain and mouse genotype. Neuropathol Appl Neurobiol 1976; 2:471-8; http://dx.doi.org/10.1111/j.1365-2990.1976.tb00521.x.
42. Jeffrey M, McGovern G, Sisó S, González L. Cellular and sub-cellular pathology of animal prion diseases: relationship between morphological changes, accumulation of abnormal prion protein and clinical disease. Acta Neuropathol 2011; 121:113-34; PMID:20532540; http://dx.doi.org/10. 1007/s00401-010-0700-3.