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Volumn 59, Issue 3, 2012, Pages 417-422

Clofarabine in pediatric acute leukemia: Current findings and issues

Author keywords

ALL; Clofarabine; New agent; Relapse

Indexed keywords

ALANINE AMINOTRANSFERASE; ANTHRACYCLINE; ASPARAGINASE MACROGOL; ASPARTATE AMINOTRANSFERASE; CLADRIBINE; CLOFARABINE; CYCLOPHOSPHAMIDE; CYTARABINE; DEOXYADENOSINE; EPIPODOPHYLLOTOXIN; ETOPOSIDE; FLUDARABINE PHOSPHATE; PERFOSFAMIDE; TRIACYLGLYCEROL LIPASE; VINCRISTINE;

EID: 84861726534     PISSN: 15455009     EISSN: 15455017     Source Type: Journal    
DOI: 10.1002/pbc.24112     Document Type: Review
Times cited : (26)

References (34)
  • 1
    • 77956408842 scopus 로고    scopus 로고
    • Outcomes for children and adolescents with cancer: Challenges for the twenty-first century
    • Smith MA, Seibel NL, Altekruse SF, et al. Outcomes for children and adolescents with cancer: Challenges for the twenty-first century. J Clin Oncol 2010; 28: 2625-2634.
    • (2010) J Clin Oncol , vol.28 , pp. 2625-2634
    • Smith, M.A.1    Seibel, N.L.2    Altekruse, S.F.3
  • 2
    • 18044390106 scopus 로고    scopus 로고
    • The role of clofarabine in hematologic and solid malignancies-development of a next-generation nucleoside analog
    • Faderl S, Gandhi V, Keating MJ, et al. The role of clofarabine in hematologic and solid malignancies-development of a next-generation nucleoside analog. Cancer 2005; 103: 1985-1995.
    • (2005) Cancer , vol.103 , pp. 1985-1995
    • Faderl, S.1    Gandhi, V.2    Keating, M.J.3
  • 3
    • 34548851697 scopus 로고    scopus 로고
    • A phase 1 clinical-laboratory study of clofarabine followed by cyclophosphamide for adults with refractory acute leukemias
    • Karp JE, Ricklis RM, Balakrishnan K, et al. A phase 1 clinical-laboratory study of clofarabine followed by cyclophosphamide for adults with refractory acute leukemias. Blood 2007; 110: 1762-1769.
    • (2007) Blood , vol.110 , pp. 1762-1769
    • Karp, J.E.1    Ricklis, R.M.2    Balakrishnan, K.3
  • 4
    • 33745586575 scopus 로고    scopus 로고
    • Clofarabine and cytarabine combination as induction therapy for acute myeloid leukemia (AML) in patients 50 years of age or older
    • Faderl S, Verstovsek S, Cortes J, et al. Clofarabine and cytarabine combination as induction therapy for acute myeloid leukemia (AML) in patients 50 years of age or older. Blood 2006; 108: 45-51.
    • (2006) Blood , vol.108 , pp. 45-51
    • Faderl, S.1    Verstovsek, S.2    Cortes, J.3
  • 6
    • 33646337195 scopus 로고    scopus 로고
    • Phase II study of clofarabine in pediatric patients with refractory or relapsed acute lymphoblastic leukemia
    • Jeha S, Gaynon PS, Razzouk BI, et al. Phase II study of clofarabine in pediatric patients with refractory or relapsed acute lymphoblastic leukemia. J Clin Oncol 2006; 24: 1917-1923.
    • (2006) J Clin Oncol , vol.24 , pp. 1917-1923
    • Jeha, S.1    Gaynon, P.S.2    Razzouk, B.I.3
  • 7
    • 82955207681 scopus 로고    scopus 로고
    • Phase 2 trial of clofarabine in combination with etoposide and cyclophosphamide in pediatric patients with refractory or relapsed acute lymphoblastic leukemia
    • Hijiya N, Thomson B, Isakoff MS, et al. Phase 2 trial of clofarabine in combination with etoposide and cyclophosphamide in pediatric patients with refractory or relapsed acute lymphoblastic leukemia. Blood 2011; 118: 6043-6049.
    • (2011) Blood , vol.118 , pp. 6043-6049
    • Hijiya, N.1    Thomson, B.2    Isakoff, M.S.3
  • 8
    • 74049150759 scopus 로고    scopus 로고
    • A multi-center phase I study of clofarabine, etoposide and cyclophosphamide in combination in pediatric patients with refractory or relapsed acute leukemia
    • Hijiya N, Gaynon P, Barry E, et al. A multi-center phase I study of clofarabine, etoposide and cyclophosphamide in combination in pediatric patients with refractory or relapsed acute leukemia. Leukemia 2009; 23: 2259-2264.
    • (2009) Leukemia , vol.23 , pp. 2259-2264
    • Hijiya, N.1    Gaynon, P.2    Barry, E.3
  • 9
    • 84863866154 scopus 로고    scopus 로고
    • A report from the children's oncology group on the safety of clofarabine in combination with cytarabine in pediatric patients with relapsed acute leukemia. The American Society of Hematology 53rd annual meeting 2010 (3076)
    • Cooper T, Alonzo TA, Gerbing RB, et al. A report from the children's oncology group on the safety of clofarabine in combination with cytarabine in pediatric patients with relapsed acute leukemia. The American Society of Hematology 53rd annual meeting 2010 (3076).
    • Cooper, T.1    Alonzo, T.A.2    Gerbing, R.B.3
  • 10
    • 70349904430 scopus 로고    scopus 로고
    • Clofarabine, cyclophosphamide and etoposide as single-course re-induction therapy for children with refractory/multiple relapsed acute lymphoblastic leukaemia
    • Locatelli F, Testi AM, Bernardo ME, et al. Clofarabine, cyclophosphamide and etoposide as single-course re-induction therapy for children with refractory/multiple relapsed acute lymphoblastic leukaemia. Br J Haematol 2009; 147: 371-378.
    • (2009) Br J Haematol , vol.147 , pp. 371-378
    • Locatelli, F.1    Testi, A.M.2    Bernardo, M.E.3
  • 11
    • 0025811415 scopus 로고
    • Effects of 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)adenine on K562 cellular metabolism and the inhibition of human ribonucleotide reductase and DNA polymerases by its 5′-triphosphate
    • Parker WB, Shaddix SC, Chang CH, et al. Effects of 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)adenine on K562 cellular metabolism and the inhibition of human ribonucleotide reductase and DNA polymerases by its 5′-triphosphate. Cancer Res 1991; 51: 2386-2394.
    • (1991) Cancer Res , vol.51 , pp. 2386-2394
    • Parker, W.B.1    Shaddix, S.C.2    Chang, C.H.3
  • 12
    • 0345466497 scopus 로고    scopus 로고
    • Biochemical pharmacology and resistance to 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine, a novel analogue of cladribine in human leukemic cells
    • Lotfi K, Mansson E, Spasokoukotskaja T, et al. Biochemical pharmacology and resistance to 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine, a novel analogue of cladribine in human leukemic cells. Clin Cancer Res 1999; 5: 2438-2444.
    • (1999) Clin Cancer Res , vol.5 , pp. 2438-2444
    • Lotfi, K.1    Mansson, E.2    Spasokoukotskaja, T.3
  • 13
    • 0034669944 scopus 로고    scopus 로고
    • Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly affecting the mitochondria
    • Genini D, Adachi S, Chao Q, et al. Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly affecting the mitochondria. Blood 2000; 96: 3537-3543.
    • (2000) Blood , vol.96 , pp. 3537-3543
    • Genini, D.1    Adachi, S.2    Chao, Q.3
  • 14
    • 0034057850 scopus 로고    scopus 로고
    • Preclinical antitumor activity of 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)adenine (Cl-F-ara-A)
    • Waud WR, Schmid SM, Montgomery JA, et al. Preclinical antitumor activity of 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)adenine (Cl-F-ara-A). Nucleosides Nucleotides Nucleic Acids 2000; 19: 447-460.
    • (2000) Nucleosides Nucleotides Nucleic Acids , vol.19 , pp. 447-460
    • Waud, W.R.1    Schmid, S.M.2    Montgomery, J.A.3
  • 15
    • 0026565544 scopus 로고
    • Synthesis and biologic activity of 2'-fluoro-2-halo derivatives of 9-beta-D-arabinofuranosyladenine
    • Montgomery JA, Shortnacy-Fowler AT, Clayton SD, et al. Synthesis and biologic activity of 2'-fluoro-2-halo derivatives of 9-beta-D-arabinofuranosyladenine. J Med Chem 1992; 35: 397-401.
    • (1992) J Med Chem , vol.35 , pp. 397-401
    • Montgomery, J.A.1    Shortnacy-Fowler, A.T.2    Clayton, S.D.3
  • 16
    • 0032917771 scopus 로고    scopus 로고
    • Antitumor activity of 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl) adenine, a novel deoxyadenosine analog, against human colon tumor xenografts by oral administration
    • Takahashi T, Kanazawa J, Akinaga S, et al. Antitumor activity of 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl) adenine, a novel deoxyadenosine analog, against human colon tumor xenografts by oral administration. Cancer Chemother Pharmacol 1999; 43: 233-240.
    • (1999) Cancer Chemother Pharmacol , vol.43 , pp. 233-240
    • Takahashi, T.1    Kanazawa, J.2    Akinaga, S.3
  • 17
    • 0026533461 scopus 로고
    • Oral antilymphocyte activity and induction of apoptosis by 2-chloro-2'-arabino-fluoro-2′-deoxyadenosine
    • Carson DA, Wasson DB, Esparza LM, et al. Oral antilymphocyte activity and induction of apoptosis by 2-chloro-2'-arabino-fluoro-2′-deoxyadenosine. Proc Natl Acad Sci USA 1992; 89: 2970-2974.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 2970-2974
    • Carson, D.A.1    Wasson, D.B.2    Esparza, L.M.3
  • 20
    • 0037445122 scopus 로고    scopus 로고
    • Phase I clinical and pharmacology study of clofarabine in patients with solid and hematologic cancers
    • Kantarjian HM, Gandhi V, Kozuch P, et al. Phase I clinical and pharmacology study of clofarabine in patients with solid and hematologic cancers. J Clin Oncol 2003; 21: 1167-1173.
    • (2003) J Clin Oncol , vol.21 , pp. 1167-1173
    • Kantarjian, H.M.1    Gandhi, V.2    Kozuch, P.3
  • 21
    • 0141482004 scopus 로고    scopus 로고
    • Phase 2 clinical and pharmacologic study of clofarabine in patients with refractory or relapsed acute leukemia
    • Kantarjian H, Gandhi V, Cortes J, et al. Phase 2 clinical and pharmacologic study of clofarabine in patients with refractory or relapsed acute leukemia. Blood 2003; 102: 2379-2386.
    • (2003) Blood , vol.102 , pp. 2379-2386
    • Kantarjian, H.1    Gandhi, V.2    Cortes, J.3
  • 22
    • 77952491723 scopus 로고    scopus 로고
    • European development of clofarabine as treatment for older patients with acute myeloid leukemia considered unsuitable for intensive chemotherapy
    • Burnett AK, Russell NH, Kell J, et al. European development of clofarabine as treatment for older patients with acute myeloid leukemia considered unsuitable for intensive chemotherapy. J Clin Oncol 2010; 28: 2389-2395.
    • (2010) J Clin Oncol , vol.28 , pp. 2389-2395
    • Burnett, A.K.1    Russell, N.H.2    Kell, J.3
  • 23
    • 9144222570 scopus 로고    scopus 로고
    • Clofarabine, a novel nucleoside analog, is active in pediatric patients with advanced leukemia
    • Jeha S, Gandhi V, Chan KW, et al. Clofarabine, a novel nucleoside analog, is active in pediatric patients with advanced leukemia. Blood 2004; 103: 784-789.
    • (2004) Blood , vol.103 , pp. 784-789
    • Jeha, S.1    Gandhi, V.2    Chan, K.W.3
  • 24
    • 33847091436 scopus 로고    scopus 로고
    • BIOV-111a European phase II trial of clofarabine (Evoltra) in refractroy and relapsed childhood acute lymphoblastic leukemia
    • Kearns PMG, Nelken B, et al. BIOV-111a European phase II trial of clofarabine (Evoltra) in refractroy and relapsed childhood acute lymphoblastic leukemia. Blood 2006; 108: abstract #1859.
    • (2006) Blood , vol.108
    • Kearns, P.M.G.1    Nelken, B.2
  • 25
    • 19944433802 scopus 로고    scopus 로고
    • Results of a phase 1-2 study of clofarabine in combination with cytarabine (ara-C) in relapsed and refractory acute leukemias
    • Faderl S, Gandhi V, O'Brien S, et al. Results of a phase 1-2 study of clofarabine in combination with cytarabine (ara-C) in relapsed and refractory acute leukemias. Blood 2005; 105: 940-947.
    • (2005) Blood , vol.105 , pp. 940-947
    • Faderl, S.1    Gandhi, V.2    O'Brien, S.3
  • 26
    • 55749096752 scopus 로고    scopus 로고
    • Clofarabine combinations as acute myeloid leukemia salvage therapy
    • Faderl S, Ferrajoli A, Wierda W, et al. Clofarabine combinations as acute myeloid leukemia salvage therapy. Cancer 2008; 113: 2090-2096.
    • (2008) Cancer , vol.113 , pp. 2090-2096
    • Faderl, S.1    Ferrajoli, A.2    Wierda, W.3
  • 27
    • 0035179950 scopus 로고    scopus 로고
    • DNA repair initiated in chronic lymphocytic leukemia lymphocytes by 4-hydroperoxycyclophosphamide is inhibited by fludarabine and clofarabine
    • Yamauchi T, Nowak BJ, Keating MJ, et al. DNA repair initiated in chronic lymphocytic leukemia lymphocytes by 4-hydroperoxycyclophosphamide is inhibited by fludarabine and clofarabine. Clin Cancer Res 2001; 7: 3580-3589.
    • (2001) Clin Cancer Res , vol.7 , pp. 3580-3589
    • Yamauchi, T.1    Nowak, B.J.2    Keating, M.J.3
  • 28
    • 50549083190 scopus 로고    scopus 로고
    • Reinduction platform for children with first marrow relapse of acute lymphoblastic Leukemia: A Children's Oncology Group Study[corrected]
    • Raetz EA, Borowitz MJ, Devidas M, et al. Reinduction platform for children with first marrow relapse of acute lymphoblastic Leukemia: A Children's Oncology Group Study[corrected]. J Clin Oncol 2008; 26: 3971-3978.
    • (2008) J Clin Oncol , vol.26 , pp. 3971-3978
    • Raetz, E.A.1    Borowitz, M.J.2    Devidas, M.3
  • 29
    • 33749263031 scopus 로고    scopus 로고
    • Discovery and development of clofarabine: A nucleoside analogue for treating cancer
    • Bonate PL, Arthaud L, Cantrell WR Jr, et al. Discovery and development of clofarabine: A nucleoside analogue for treating cancer. Nat Rev Drug Discov 2006; 5: 855-863.
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 855-863
    • Bonate, P.L.1    Arthaud, L.2    Cantrell Jr., W.R.3
  • 30
    • 77954911871 scopus 로고    scopus 로고
    • Oral clofarabine in the treatment of patients with higher-risk myelodysplastic syndrome
    • Faderl S, Garcia-Manero G, Estrov Z, et al. Oral clofarabine in the treatment of patients with higher-risk myelodysplastic syndrome. J Clin Oncol 2010; 28: 2755-2760.
    • (2010) J Clin Oncol , vol.28 , pp. 2755-2760
    • Faderl, S.1    Garcia-Manero, G.2    Estrov, Z.3
  • 31
    • 77958196417 scopus 로고    scopus 로고
    • Epigenetic silencing of BIM in glucocorticoid poor-responsive pediatric acute lymphoblastic leukemia, and its reversal by histone deacetylase inhibition
    • Bachmann PS, Piazza RG, Janes ME, et al. Epigenetic silencing of BIM in glucocorticoid poor-responsive pediatric acute lymphoblastic leukemia, and its reversal by histone deacetylase inhibition. Blood 2010; 116: 3013-3022.
    • (2010) Blood , vol.116 , pp. 3013-3022
    • Bachmann, P.S.1    Piazza, R.G.2    Janes, M.E.3
  • 32
    • 84928588589 scopus 로고    scopus 로고
    • Clofarabine induces hypomethylation of DNA and expression of cancer-testis antigens. ASH Annual Meeting Abstracts
    • Zhang Y, Zhang J, Shahriar M, et al. Clofarabine induces hypomethylation of DNA and expression of cancer-testis antigens. ASH Annual Meeting Abstracts 2008; 112: 379.
    • (2008) , vol.112 , pp. 379
    • Zhang, Y.1    Zhang, J.2    Shahriar, M.3
  • 33
    • 78650244965 scopus 로고    scopus 로고
    • Influence of clofarabine on transcriptional activity of PTEN, APC, RARB2, ZAP70 genes in K562 cells
    • Majda K, Kaufman-Szymczyk A, Lubecka-Pietruszewska K, et al. Influence of clofarabine on transcriptional activity of PTEN, APC, RARB2, ZAP70 genes in K562 cells. Anticancer Res 2010; 30: 4601-4606.
    • (2010) Anticancer Res , vol.30 , pp. 4601-4606
    • Majda, K.1    Kaufman-Szymczyk, A.2    Lubecka-Pietruszewska, K.3
  • 34
    • 79960844332 scopus 로고    scopus 로고
    • Early UK experience in the use of clofarabine in the treatment of relapsed and refractory paediatric acute lymphoblastic leukaemia
    • O'Connor D, Sibson K, Caswell M, et al. Early UK experience in the use of clofarabine in the treatment of relapsed and refractory paediatric acute lymphoblastic leukaemia. Br J Haematol 2011; 154: 482-485.
    • (2011) Br J Haematol , vol.154 , pp. 482-485
    • O'Connor, D.1    Sibson, K.2    Caswell, M.3


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