Modelling of individual subject ozone exposure response kinetics

Inhalation Toxicology

Volumn 24, Issue 7, 2012, Pages 401-415

  Schelegle, Edward S ^a   Adams, William C ^a   Walby, William F ^a   Marion, M Susan ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Exposureresponse model; Human; Ozone

Indexed keywords

OZONE;

ADULT; ARTICLE; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; HUMAN EXPERIMENT; INHALATION; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RISK ASSESSMENT; VALIDATION STUDY;

ADMINISTRATION, INHALATION; ADOLESCENT; ADULT; AIR POLLUTANTS; CLINICAL TRIALS AS TOPIC; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FORCED EXPIRATORY VOLUME; HUMANS; INHALATION EXPOSURE; KINETICS; MALE; MODELS, BIOLOGICAL; OZONE; YOUNG ADULT;

EID: 84861723024     PISSN: 08958378     EISSN: 10917691     Source Type: Journal    
DOI: 10.3109/08958378.2012.683891     Document Type: Article

References (32)

1. Adams WC. 2000a. Feasibility study of prolonged ozone inhalation exposure via face mask. Inhal Toxicol 12:299-313.
2. Adams WC. 2000b. Ozone dose-response effects of varied equivalent minute ventilation rates. J Expo Anal Environ Epidemiol 10:217-226.
3. Adams WC. 2002. Comparison of chamber and face-mask 6.6-hour exposures to ozone on pulmonary function and symptoms responses. Inhal Toxicol 14:745-764.
4. Adams WC. 2003a. Comparison of chamber and face mask 6.6-hour exposure to 0.08 ppm ozone via square-wave and triangular profiles on pulmonary responses. Inhal Toxicol 15:265-281.
5. Adams WC. 2003b. Relation of pulmonary responses induced by 6.6-h exposures to 0.08 ppm ozone and 2-h exposures to 0.30 ppm ozone via chamber and face-mask inhalation. Inhal Toxicol 15:745-759.
6. Adams WC. 2006a. Comparison of chamber 6.6-h exposures to 0.04-0.08 PM ozone via square-wave and triangular profiles on pulmonary responses. Inhal Toxicol 18:127-136.
7. Adams WC. 2006b. Human pulmonary responses with 30-minute time intervals of exercise and rest when exposed for 8 hours to 0.12 ppm ozone via square-wave and acute triangular profiles. Inhal Toxicol 18:413-422.
8. Adams WC, Ollison WM. 1997. Effects of prolonged simulated ambient ozone dosing patterns on human pulmonary function and symptomatology. June 8-13, 97-MP9.02, pp. 1-16.
9. Adams WC, Savin WM, Christo AE. 1981. Detection of ozone toxicity during continuous exercise via the effective dose concept. J Appl Physiol 51:415-422.
10. Birge B. 2003 PSOt - a particle swarm optimization toolbox for use with Matlab. IEEE Swarm Intelligence Symposium. Indianapolis, Indiana, IEEE.
11. EPA (1996) Air quality criteria for ozone and related photochemical oxidants. In: Development OOR, ed. Research Triangle Park, NC: NTIS, Springfield, V.A.
12. Folinsbee LJ, Drinkwater BL, Bedi JF, Horvath SM. 1978 The influence of exercise on the pulmonary function changes due to low concentrations of ozone. In: Folinsbee LJ, ed. Environmental Stress. New York: Academic Press.
13. Folinsbee LJ, McDonnell WF, Horstman DH. 1988. Pulmonary function and symptom responses after 6.6-hour exposure to 0.12 ppm ozone with moderate exercise. JAPCA 38:28-35.
14. Glantz SA 2002 Primer of biostatistics, New York: McGraw-Hill, Medical Pub. Div. Hazucha M, Silverman F, Parent C, Field S, Bates DV. 1973. Pulmonary function in man after short-term exposure to ozone. Arch Environ Health 27:183-188.
15. Hazucha MJ. 1987. Relationship between ozone exposure and pulmonary function changes. J Appl Physiol 62:1671-1680.
16. Horstman DH, Ball BA, Brown J, Gerrity T, Folinsbee LJ. 1995. Comparison of pulmonary responses of asthmatic and nonasthmatic subjects performing light exercise while exposed to a low level of ozone. Toxicol Ind Health 11:369-385.
17. Horstman DH, Folinsbee LJ, Ives PJ, Abdul-Salaam S, McDonnell WF. 1990. Ozone concentration and pulmonary response relationships for 6.6-hour exposures with five hours of moderate exercise to 0.08, 0.10, and 0.12 ppm. Am Rev Respir Dis 142:1158-1163.
18. Kehrl HR, Vincent LM, Kowalsky RJ, Horstman DH, O'Neil JJ, McCartney WH, Bromberg PA. 1987. Ozone exposure increases respiratory epithelial permeability in humans. Am Rev Respir Dis 135:1124-1128.
19. Koren HS, Devlin RB, Graham, DE, Al E. 1989 Ozone-induced inflammation in the lower airway of human subjects. Am.Rev. Respir.Dis 139:407-415.
20. Kulle TJ, Sauder LR, Hebel JR, Chatham MD. 1985. Ozone response relationships in healthy nonsmokers. Am Rev Respir Dis 132:36-41.
21. Mcdonnell WF 1989 Individual variability in the magnitude of acute respiratory response to ozone exposure. In: Frank MJUAR, ed. Susceptibility to inhaled pollutants. Philadelphia:American Society for Testing and Materials. McDonnell WF, Horstman DH, Abdul-Salaam S, Raggio LJ, Green JA. 1987. The respiratory responses of subjects with allergic rhinitis to ozone exposure and their relationship to nonspecific airway reactivity. Toxicol Ind Health 3:507-517.
22. McDonnell WF, Horstman DH, Hazucha MJ, Seal E Jr, Haak ED, Salaam SA, House DE. 1983. Pulmonary effects of ozone exposure during exercise: dose-response characteristics. J Appl Physiol 54:1345-1352.
23. McDonnell WF, Kehrl HR, Abdul-Salaam S, Ives PJ, Folinsbee LJ, Devlin RB, O'Neil JJ, Horstman DH. 1991. Respiratory response of humans exposed to low levels of ozone for 6.6 hours. Arch Environ Health 46:145-150.
24. McDonnell WF, Stewart PW, Andreoni S, Seal E Jr, Kehrl HR, Horstman DH, Folinsbee LJ, Smith MV. 1997. Prediction of ozone-induced FEV1 changes. Effects of concentration, duration, and ventilation. Am J Respir Crit Care Med 156:715-722.
25. McDonnell WF, Stewart PW, Smith MV. 2007. The temporal dynamics of ozone-induced FEV1 changes in humans: An exposure-response model. Inhal Toxicol 19:483-494.
26. McDonnell WF, Stewart PW, Smith MV. 2010. Prediction of ozoneinduced lung function responses in humans. Inhal Toxicol 22:160-168.
27. McDonnell WF, Stewart PW, Smith MV, Pan WK, Pan J. 1999. Ozoneinduced respiratory symptoms: Exposure-response models and association with lung function. Eur Respir J 14:845-853.
28. Schelegle ES, Adams WC, Giri SN, Siefkin AD. 1989. Acute ozone exposure increases plasma prostaglandin F2 alpha in ozonesensitive human subjects. Am Rev Respir Dis 140:211-216.
29. Schelegle ES, Morales CA, Walby WF, Marion S, Allen RP. 2009. 6.6-hour inhalation of ozone concentrations from 60 to 87 parts per billion in healthy humans. Am J Respir Crit Care Med 180:265-272.
30. Schelegle ES, Walby WF, Adams WC. 2007. Time course of ozoneinduced changes in breathing pattern in healthy exercising humans. J Appl Physiol 102:688-697.
31. Seal E Jr, McDonnell WF, House DE, Salaam SA, Dewitt PJ, Butler SO, Green J, Raggio L. 1993. The pulmonary response of white and black adults to six concentrations of ozone. Am Rev Respir Dis 147:804-810.
32. Silverman F, Folinsbee LJ, Barnard J, Shephard RJ. 1976. Pulmonary function changes in ozone-interaction of concentration and ventilation. J Appl Physiol 41:859-864.