6.6-Hour inhalation of ozone concentrations from 60 to 87 parts per billion in healthy humans

American Journal of Respiratory and Critical Care Medicine

Volumn 180, Issue 3, 2009, Pages 265-272

  Schelegle, Edward S ^a   Morales, Christopher A ^a   Walby, William F ^a   Marion, Susan ^b   Allen, Roblee P ^c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Clinical study; Exposure assessment; Human; Ozone

Indexed keywords

OZONE;

ADULT; AIR QUALITY; AMBIENT AIR; ARTICLE; CONCENTRATION (PARAMETERS); FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; LUNG FUNCTION; MALE; NORMAL HUMAN; OXYGEN CONCENTRATION; OZONE LAYER; PREDICTION; PRIORITY JOURNAL; RISK ASSESSMENT; STATISTICAL SIGNIFICANCE;

ADMINISTRATION, INHALATION; ADOLESCENT; ADULT; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL EXPOSURE; FEMALE; FORCED EXPIRATORY VOLUME; HUMANS; LUNG; MALE; OXIDANTS, PHOTOCHEMICAL; OZONE; REFERENCE VALUES; VITAL CAPACITY; YOUNG ADULT;

EID: 67749103588     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.200809-1484OC     Document Type: Article

References (23)

1. Silverman F, Folinsbee LJ, Barnard J, Shephard RJ. Pulmonary function changes in ozone-interaction of concentration and ventilation. J Appl Physiol 1976;41:859-864.
2. Folinsbee LJ, Drinkwater BL, Bedi JF, Horvath SM. The influence of exercise on the pulmonary function changes due to low concentrations of ozone. In: Folinsbee LJ, editor. Environmental stress. New York: Academic Press; 1978. pp. 125-145.
3. McDonnell WF, Hortsman DH, Hazucha MJ, Seal E Jr, Haak ED, Salaam SA, House DE. Pulmonary effects of ozone exposure during exercise: dose-response characteristics. J Appl Physiol 1983;54:1345-1352.
4. Adams WC, Savin WM, Christo AE. Detection of ozone toxicity during continuous exercise via the effective dose concept. J Appl Physiol 1981;51:415-422.
5. Schelegle ES, Adams WC. Reduced exercise time in competitive simulations consequent to low level ozone exposure. Med Sci Sports Exerc 1986;18:408-414.
6. Folinsbee LJ, McDonnell WF, Horstman DH. Pulmonary function and symptom responses after 6.6-hour exposure to 0.12 ppm ozone with moderate exercise. JAPCA 1988;38:28-35.
7. McDonnell WF, Kehrl HR, Abdul-Salaam S, Ives PJ, Folinsbee LJ, Devlin RB, O'Neil JJ, Horstman DH. Respiratory response of humans exposed to low levels of ozone for 6.6 hours. Arch Environ Health 1991;46:145-150.
8. Horstman DH, Folinsbee LJ, Ives PJ, Abdul-Salaam S, McDonnell WF. Ozone concentration and pulmonary response relationships for 6.6-hour exposures with five hours of moderate exercise to 0.08, 0.10, and 0.12 ppm. Am Rev Respir Dis 1990;142:1158-1163.
9. Adams WC. Comparison of chamber 6.6-h exposures to 0.04-0.08 ppm ozone via square-wave and triangular profiles on pulmonary responses. Inhal Toxicol 2006;18:127-136.
10. Adams WC. Comparison of chamber and face mask 6.6-hour exposure to 0.08 ppm ozone via square-wave and triangular profiles on pulmonary responses. Inhal Toxicol 2003;15:265-281.
11. Adams WC. Comparison of chamber and face-mask 6.6-hour exposures to ozone on pulmonary function and symptoms responses. Inhal Toxicol 2002;14:745-764.
12. Schelegle ES, Walby WF, Adams WC. Time course of ozone-induced changes in breathing pattern in healthy exercising humans. J Appl Physiol 2007;102:688-697.
13. Schelegle ES, Morales CA, Walby WF, Allen RP. 6.6 Hour human ozone exposures with varying time-concentration profiles above and below the current air quality standard [abstract]. Am J Respir Crit Care Med 2008;177:A428.
14. Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, Crapo R, Enright P, van der Grinten CP, Gustafsson P, et al. Standardisation of spirometry. Eur Respir J 2005;26:319-338.
15. 3 on young men and women. J Appl Physiol 1987;62:1698-1704.
16. Littell RC, Henry PR, Ammerman CB. Statistical analysis of repeated measures data using SAS procedures. J Anim Sci 1998;76:1216-1231.
17. Glantz SA. Primer of biostatistics, 5th ed. New York: McGraw-Hill; 2002. pp. 298-381.
18. Aitken ML, Franklin JL, Pierson DJ, Schoene RB. Influence of body size and gender on control of ventilation. J Appl Physiol 1986;60:1894-1899.
19. 1 in humans: a secondary analysis of existing data. Environ Health Perspect 2008;116:1023-1026.
20. Linn WS, Spier CE, Hackney JD. Activity patterns in ozone-exposed construction workers. J Occup Med Toxicol 1993;2:1-14.
21. Hazucha MJ, Bates BV, Bromberg PA. Mechanism of action of ozone on the human lung. J Appl Physiol 1989;67:1535-1541.
22. Schelegle ES, Elderidge MW, Cross CE, Walby WF, Adams WC. Differential effects of airway anesthesia on ozone-induced pulmonary responses in human subjects. Am J Respir Crit Care Med 2001;163:1121-1127.
23. Passannante AN, Hazucha MJ, Bromberg PA, Seal E, Folinsbee L, Koch G. Nociceptive mechanisms modulate ozone-induced human lung function decrements. J Appl Physiol 1998;85:1863-1870.