메뉴 건너뛰기




Volumn 3, Issue 2, 2012, Pages 70-74

Antihyperglycemic and hypolipidemic activities of aqueous extract of Carica papaya Linn. leaves in alloxan-induced diabetic rats

Author keywords

Aqueous leaf extract; Carica papaya Linn; hypoglycemia; hypolipidemia

Indexed keywords

ALLOXAN; CARICA PAPAYA EXTRACT; GLIBENCLAMIDE; GLUCOSE; LIPID;

EID: 84861706213     PISSN: 09759476     EISSN: 09762809     Source Type: Journal    
DOI: 10.4103/0975-9476.96519     Document Type: Article
Times cited : (52)

References (35)
  • 1
    • 0004555510 scopus 로고
    • Diabetes mellitus
    • Wyngarden JB, Smith LH, Bennett JC, editors, Philadelphia: WB Saunders
    • Olefasky JM. Diabetes mellitus In: Wyngarden JB, Smith LH, Bennett JC, editors. Text book of Medicine. Vol. 17. Philadelphia: WB Saunders; 1985. p. 1320-41.
    • (1985) Text Book of Medicine , vol.17 , pp. 1320-1341
    • Olefasky, J.M.1
  • 2
    • 34249293462 scopus 로고    scopus 로고
    • Diabetes and impaired glucose tolerance
    • Gan D, editor. Belgium: International Diabetes Federation
    • Sicree R, Shaw J, Zimmet P. Diabetes and impaired glucose tolerance. In: Gan D, editor. Diabetes Atlas. 3rd ed., Vol. 15. Belgium: International Diabetes Federation; 2006. p. 103.
    • (2006) Diabetes Atlas. 3rd Ed , vol.15 , pp. 103
    • Sicree, R.1    Shaw, J.2    Zimmet, P.3
  • 3
    • 51049086993 scopus 로고    scopus 로고
    • Development of HPTLC method for estimation of charantin in herbal formulations
    • Patel PM, Patel KN, Patel NM, Goyal RK. Development of HPTLC method for estimation of charantin in herbal formulations. Pharmacog Mag 2006;8:224-6.
    • (2006) Pharmacog Mag , vol.8 , pp. 224-226
    • Patel, P.M.1    Patel, K.N.2    Patel, N.M.3    Goyal, R.K.4
  • 4
    • 0028835878 scopus 로고
    • Antidiabetic plants and their active constituents
    • Marlos RJ, Farnsworth NR. Antidiabetic plants and their active constituents. Phytomedicine 1995;2:137-89.
    • (1995) Phytomedicine , vol.2 , pp. 137-189
    • Marlos, R.J.1    Farnsworth, N.R.2
  • 5
    • 0038118327 scopus 로고    scopus 로고
    • Herbs for serum cholesterol reduction: A systematic review
    • Thompson Coon JS, Earnst E. Herbs for serum cholesterol reduction systemic review. J Fam Pract 2003;52:468-78. (Pubitemid 36706162)
    • (2003) Journal of Family Practice , vol.52 , Issue.6 , pp. 468-478
    • Thompson Coon, J.S.1    Ernst, E.2
  • 6
    • 0036988286 scopus 로고    scopus 로고
    • Importance of biologically active components and plants in the prevention of complications of diabetes mellitus
    • Savickiene N, Dagilyte A, Lukosius A, Zitkevicius U. Importance of biologically active components and plants in the prevention of complications of diabetes mellitus. Medicina (Kaunas) 2002;38:970-5.
    • (2002) Medicina (Kaunas) , vol.38 , pp. 970-975
    • Savickiene, N.1    Dagilyte, A.2    Lukosius, A.3    Zitkevicius, U.4
  • 7
    • 1642432878 scopus 로고    scopus 로고
    • Drug discovery and development for metabolic diseases
    • DOI 10.1016/S1359-6446(03)02919-2, PII S1359644603029192
    • Hooft R. Drug discovery and development for metabolic diseases. Drug Discov Today 2003;8:1064-6. (Pubitemid 38121224)
    • (2003) Drug Discovery Today , vol.8 , Issue.23 , pp. 1064-1066
    • Hooft, R.1
  • 8
    • 84861674671 scopus 로고    scopus 로고
    • 2 ed. Oriental Watchman Publishing House Pune, India
    • Kurian JC. Plants that Heal. 2 ed. Oriental Watchman Publishing House Pune, India; 2001. 37: 55 p. 264-300.
    • (2001) Plants That Heal , vol.37-55 , pp. 264-300
    • Kurian, J.C.1
  • 9
    • 80051842204 scopus 로고    scopus 로고
    • The in-vitro antibacterial activity of methanol and ethanol extracts of Carica papaya fl owers and Mangifera indica leaves
    • Mohamed Isa SS, Riffi n S. The in-vitro antibacterial activity of methanol and ethanol extracts of Carica papaya fl owers and Mangifera indica leaves. J Pharmacol Toxicol 2006;1:278-83.
    • (2006) J Pharmacol Toxicol , vol.1 , pp. 278-283
    • Mohamed Isa, S.S.1    Riffi, N.S.2
  • 10
    • 0033404136 scopus 로고    scopus 로고
    • Reversible azoospermia by oral administration of the benzene chromatographic fraction of the chloroform extract of the seeds of Carica papaya in rabbits
    • DOI 10.1023/A:1006701826831
    • Lohiya NK, Mishra PK, Pathak N, Munivannan B, Jain SC. Reversible azospermia by oral administration of the benzene chromatographic fraction of the chloroform extract of the seeds of Carica papaya in rabbits. Adv Contracept 1999;15:141-61. (Pubitemid 30042545)
    • (1999) Advances in Contraception , vol.15 , Issue.2 , pp. 141-161
    • Lohiya, N.K.1    Mishra, P.K.2    Pathak, N.3    Manivannan, B.4    Jain, S.C.5
  • 11
    • 0028832331 scopus 로고
    • Anthelmintic activity of papaya latex against patent Heligmosomoides polygyrus infections in mice
    • Satrija F, Nansen P, Murtini S, He S. Anthelmintic activity of papaya latex against patent Heligmosomoides polygyrus infections in mice. J Ethnopharm 1995;3:161-4.
    • (1995) J Ethnopharm , vol.3 , pp. 161-164
    • Satrija, F.1    Nansen, P.2    Murtini, S.3    He, S.4
  • 12
    • 34548733222 scopus 로고    scopus 로고
    • Anti-infl ammatory activity of ethanolic leaf extract from Carica papaya in rats, orogastrically dosed with Salmonella typhi and Staphylococcus aureus
    • Oladunmoye MK, Osho IB. Anti-infl ammatory activity of ethanolic leaf extract from Carica papaya in rats, orogastrically dosed with Salmonella typhi and Staphylococcus aureus. J Plant Sci 2007;2:447-445.
    • (2007) J Plant Sci , vol.2 , pp. 447-445
    • Oladunmoye, M.K.1    Osho, I.B.2
  • 13
    • 84861708020 scopus 로고
    • Ca-Ci, Publication and Information Directorate, CSIR, New Delhi, India
    • Anonymous. The Wealth of India. Raw materials. Ca-Ci, Publication and Information Directorate, CSIR, New Delhi, India.1992. p. 287-93.
    • (1992) Anonymous. The Wealth of India. Raw Materials , pp. 287-293
  • 15
    • 0019993645 scopus 로고
    • Antibacterial substance from Carica papaya fruit extract
    • DOI 10.1021/np50020a002
    • Emeruwa AC. Antibacterial substance from Carica papaya fruit extract. J Nat Prod.1982;45:123-7. (Pubitemid 12025566)
    • (1982) Journal of Natural Products , vol.45 , Issue.2 , pp. 123-127
    • Emeruwa, A.C.1
  • 17
    • 0009120831 scopus 로고
    • Preliminary studies on the hypoglycemic activity of ethanolic extract of unripe mature fruits of Carica papaya
    • Olagunja JA, Ogunlana CO, Gbile Z. Preliminary studies on the hypoglycemic activity of ethanolic extract of unripe mature fruits of Carica papaya. Nig J Biochem Mol Biol 1995;10:21-3.
    • (1995) Nig J Biochem Mol Biol , vol.10 , pp. 21-23
    • Olagunja, J.A.1    Ogunlana, C.O.2    Gbile, Z.3
  • 18
    • 78650741153 scopus 로고    scopus 로고
    • Preliminary hypoglycemic and hypolipidemic activities of aqueous seed extract of Carica papaya Linn in Wistar rats
    • Adeneye AA, Olagunja JA. Preliminary hypoglycemic and hypolipidemic activities of aqueous seed extract of Carica papaya Linn in Wistar rats. Biol Med 2009;1:1-10.
    • (2009) Biol Med , vol.1 , pp. 1-10
    • Adeneye, A.A.1    Olagunja, J.A.2
  • 21
    • 0018177839 scopus 로고
    • An interlaboratory comparison of serum total protein analysis
    • Burckhardt RT, Batsakis JC. An interlaboratory comparison of serum total protein analysis. Am J Clin Pathol 1978;70(3 Suppl):508-10.
    • (1978) Am J Clin Pathol , vol.70 , Issue.SUPPL.. , pp. 508-510
    • Burckhardt, R.T.1    Batsakis, J.C.2
  • 22
    • 0030964936 scopus 로고    scopus 로고
    • Precipitation methods for high density lipoprotein cholesterol measurement compared and fi nal evaluation under routine operating conditions of a method with low sample to reagent ratio
    • Pierre NM, Demackerl A, Marja H, Helga TD, Henk B. Precipitation methods for high density lipoprotein cholesterol measurement compared and fi nal evaluation under routine operating conditions of a method with low sample to reagent ratio. Clin Chem 1997;43:663-8.
    • (1997) Clin Chem , vol.43 , pp. 663-668
    • Pierre, N.M.1    Demackerl, A.2    Marja, H.3    Helga, T.D.4    Henk, B.5
  • 23
    • 0020680990 scopus 로고
    • A peroxidase-coupled method for the colorimetric determination of serum triglycerides
    • Me Gown MW, Artiss JD, Strand berg DR, Zak B. A peroxidase coupled method for the calorimetric determination of serum triglycerides. Clin Chem 1983;29:538-42. (Pubitemid 13160770)
    • (1983) Clinical Chemistry , vol.29 , Issue.3 , pp. 538-542
    • McGowan, M.W.1    Artiss, J.D.2    Strandbergh, D.R.3    Zak, B.4
  • 24
    • 0023748601 scopus 로고
    • Alloxan; History and mechanism of action
    • Lenzen S, Panten U. Alloxan; history and mechanism of action. Diabetologia 1988;31:337-42.
    • (1988) Diabetologia , vol.31 , pp. 337-342
    • Lenzen, S.1    Panten, U.2
  • 25
    • 0023770113 scopus 로고
    • Free radicals and diabetes
    • DOI 10.1016/0891-5849(88)90036-6
    • Oberley LW. Free radicals and diabetes. Free Radiol Biol Med 1988;5:113-24. (Pubitemid 18263730)
    • (1988) Free Radical Biology and Medicine , vol.5 , Issue.2 , pp. 113-124
    • Oberley, L.W.1
  • 26
    • 1842373814 scopus 로고    scopus 로고
    • Comparative toxicity of alloxan, N-alkylalloxans and ninhydrin to isolated pancreatic islets in vitro
    • DOI 10.1677/joe.0.1550283
    • Jorns A, Munday R, Tiedge M, Lenzen S. Comparative toxicity of alloxan, N-alkyl alloxan and ninhydrin to isolated pancreatic islets in vitro. J Endocrinol 1997;155:283-93. (Pubitemid 27475824)
    • (1997) Journal of Endocrinology , vol.155 , Issue.2 , pp. 283-293
    • Jorns, A.1    Munday, R.2    Tiedge, M.3    Lenzen, S.4
  • 27
    • 0035691617 scopus 로고    scopus 로고
    • The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas
    • Szkudelski T. The mechanism of alloxan and streptozotocin action in beta cells of the rat pancreas. Physiol Res 2001;50:537-46. (Pubitemid 34087272)
    • (2001) Physiological Research , vol.50 , Issue.6 , pp. 537-546
    • Szkudelski, T.1
  • 28
    • 0034099839 scopus 로고    scopus 로고
    • Hypoglycaemic and other related actions of Tinospora cordifolia roots in alloxan-induced diabetic rats
    • DOI 10.1016/S0378-8741(99)00136-1, PII S0378874199001361
    • Prince SM, Menon VP. Hypoglycemic and other related actions of Tinospora cardifolia roots in alloxan induced diabetic rats. J Ethnopharmacol 2000;70:9-15. (Pubitemid 30138065)
    • (2000) Journal of Ethnopharmacology , vol.70 , Issue.1 , pp. 9-15
    • Stanely, P.1    Prince, M.2    Menon, V.P.3
  • 29
    • 0035134455 scopus 로고    scopus 로고
    • Hypoglycemic effect of the water extract of Smallantus sonchifolius (yacon) leaves in normal and diabetic rats
    • DOI 10.1016/S0378-8741(00)00351-2, PII S0378874100003512
    • Ayber MJ, Riera AN, Grau A, Sanchhez SS. Hypoglycemic effect of Smallanthus soncitolius water extract of leaves in normal and diabetic rats. J Ethnopharmacol 2001;74:125-32. (Pubitemid 32141094)
    • (2001) Journal of Ethnopharmacology , vol.74 , Issue.2 , pp. 125-132
    • Aybar, M.J.1    Sanchez Riera, A.N.2    Grau, A.3    Sanchez, S.S.4
  • 30
    • 0002096610 scopus 로고    scopus 로고
    • Insulin, oral agents and the pharmacology of endocrine pancreas
    • Hardman JG, Limbard LE, Gillman AG, editors. New York: Mc Graw Hill Co. Incorp
    • Davis SN, Granner DK. Insulin, oral agents and the pharmacology of endocrine pancreas. Goodman and Gillman's The Pharmacological Basis of Therapeutics. Hardman JG, Limbard LE, Gillman AG, editors. New York: Mc Graw Hill Co. Incorp.; 2001. p. 1679-714.
    • (2001) Goodman and Gillman's the Pharmacological Basis of Therapeutics , pp. 1679-1714
    • Davis, S.N.1    Granner, D.K.2
  • 31
    • 0028097811 scopus 로고
    • Management of dyslipidemia in IDDM patients
    • Garg A. Management of dyslipidemia in IDDM patients. Diabetic Care 1994;17:224-34. (Pubitemid 24065521)
    • (1994) Diabetes Care , vol.17 , Issue.3 , pp. 224-234
    • Garg, A.1
  • 32
    • 0035053234 scopus 로고    scopus 로고
    • Clinical review 124: Diabetic dyslipidemia - Causes and consequences
    • DOI 10.1210/jc.86.3.965
    • Goldberg IJ. Clinical review 124. Diabetic dyslipidemia; Causes and consequences. J Clin Endocrinol Metab 2001;86:965-71. (Pubitemid 32322966)
    • (2001) Journal of Clinical Endocrinology and Metabolism , vol.86 , Issue.3 , pp. 965-971
    • Goldberg, I.J.1
  • 33
    • 38749106579 scopus 로고    scopus 로고
    • Anti-hyperglycaemic and hypolipidemic effects of Ocimum basilicum aqueous extract in diabetic rats
    • Zeggwagh NA, Sulpice T, Eddouks M. Antihyperglycemic and hypolipidemic effects of Ocimum basilium aqueous extract in diabetic rats. Am J Pharmacol Toxicol 2007;2:123-9. (Pubitemid 351181647)
    • (2007) American Journal of Pharmacology and Toxicology , vol.2 , Issue.3 , pp. 123-129
    • Zeggwagh, N.A.1    Sulpice, T.2    Eddouks, M.3
  • 34
    • 77951757839 scopus 로고    scopus 로고
    • Hypoglycemic and hypolipidemic effects of an aqueous extract of Chamaerops humilis leaves in obese, hyperglycemic and hypolipidemic Meriones shawi rats
    • Gaamoussi F, Israili Z, Lyoussi B. Hypoglycemic and hypolipidemic effects of an aqueous extract of Chamaerops humilis leaves in obese, hyperglycemic and hypolipidemic Meriones shawi rats. Pak J Pharm Sci 2010;23:212-9.
    • (2010) Pak J Pharm Sci , vol.23 , pp. 212-219
    • Gaamoussi, F.1    Israili, Z.2    Lyoussi, B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.