메뉴 건너뛰기




Volumn 13, Issue 4, 2012, Pages 321-327

Macrophage-stimulating protein polymorphism rs3197999 is associated with a gain of function: Implications for inflammatory bowel disease

Author keywords

Crohn's disease; MST1; primary sclerosing cholangitis; ulcerative colitis

Indexed keywords

MACROPHAGE ACTIVATING FACTOR; MST1 PROTEIN; RECOMBINANT GAMMA INTERFERON; RECOMBINANT TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 84861694008     PISSN: 14664879     EISSN: 14765470     Source Type: Journal    
DOI: 10.1038/gene.2011.88     Document Type: Article
Times cited : (16)

References (45)
  • 1
    • 38649115342 scopus 로고    scopus 로고
    • Microbial influences in inflammatory bowel diseases
    • DOI 10.1053/j.gastro.2007.11.059, PII S0016508507021579
    • Sartor RB. Microbial influences in inflammatory bowel diseases. Gastroenterology 2008; 134: 577-594. (Pubitemid 351173057)
    • (2008) Gastroenterology , vol.134 , Issue.2 , pp. 577-594
    • Sartor, R.B.1
  • 2
    • 34547176642 scopus 로고    scopus 로고
    • Unravelling the pathogenesis of inflammatory bowel disease
    • DOI 10.1038/nature06005, PII NATURE06005
    • Xavier RJ, Podolsky DK. Unravelling the pathogenesis of inflammatory bowel disease. Nature 2007; 448: 427-434. (Pubitemid 47123518)
    • (2007) Nature , vol.448 , Issue.7152 , pp. 427-434
    • Xavier, R.J.1    Podolsky, D.K.2
  • 3
    • 79955566359 scopus 로고    scopus 로고
    • Recent insights into the genetics of inflammatory bowel disease
    • Cho JH, Brant SR. Recent insights into the genetics of inflammatory bowel disease. Gastroenterology 2011; 140: 1704-1712.e2.
    • (2011) Gastroenterology , vol.140
    • Cho, J.H.1    Brant, S.R.2
  • 4
    • 78649489009 scopus 로고    scopus 로고
    • Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
    • Franke A, McGovern DPB, Barrett JC, Wang K, Radford-Smith GL, Ahmad T et al. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet 2010; 42: 1118-1125.
    • (2010) Nat Genet , vol.42 , pp. 1118-1125
    • Franke, A.1    McGovern, D.P.B.2    Barrett, J.C.3    Wang, K.4    Radford-Smith, G.L.5    Ahmad, T.6
  • 5
    • 23344446570 scopus 로고    scopus 로고
    • Intestinal macrophages: Unique effector cells of the innate immune system
    • DOI 10.1111/j.0105-2896.2005.00288.x
    • Smith PD, Ochsenbauer-Jambor C, Smythies LE. Intestinal macrophages: unique effector cells of the innate immune system. Immunol Rev 2005; 206: 149-159. (Pubitemid 41105168)
    • (2005) Immunological Reviews , vol.206 , pp. 149-159
    • Smith, P.D.1    Ochsenbauer-Jambor, C.2    Smythies, L.E.3
  • 6
    • 0035044890 scopus 로고    scopus 로고
    • The prevalence of extraintestinal diseases in inflammatory bowel disease: A population-based study
    • DOI 10.1016/S0002-9270(01)02319-X, PII S000292700102319X
    • Bernstein CN, Blanchard JF, Rawsthorne P, Yu N. The prevalence of extraintestinal diseases in inflammatory bowel disease: a population-based study. Am J Gastroenterol 2001; 96: 1116-1122. (Pubitemid 32319146)
    • (2001) American Journal of Gastroenterology , vol.96 , Issue.4 , pp. 1116-1122
    • Bernstein, C.N.1    Blanchard, J.F.2    Rawsthorne, P.3    Yu, N.4
  • 7
    • 0034971844 scopus 로고    scopus 로고
    • Accumulation of macrophages in primary sclerosing cholangitis
    • DOI 10.1016/S0009-9120(01)00215-6, PII S0009912001002156
    • Cameron RG, Blendis LM, Neuman MG. Accumulation of macrophages in primary sclerosing cholangitis. Clin Biochem 2001; 34: 195-201. (Pubitemid 32537671)
    • (2001) Clinical Biochemistry , vol.34 , Issue.3 , pp. 195-201
    • Cameron, R.G.1    Blendis, L.M.2    Neuman, M.G.3
  • 8
    • 80054897554 scopus 로고    scopus 로고
    • Cutting edge issues in primary sclerosing cholangitis
    • Bowlus C. Cutting edge issues in primary sclerosing cholangitis. Clin Rev Allergy Immunol 2011; 41: 139-150.
    • (2011) Clin Rev Allergy Immunol , vol.41 , pp. 139-150
    • Bowlus, C.1
  • 10
    • 48349136889 scopus 로고    scopus 로고
    • Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
    • Barrett JC, Hansoul S, Nicolae DL, Cho JH, Duerr RH, Rioux JD et al. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet 2008; 40: 955-962.
    • (2008) Nat Genet , vol.40 , pp. 955-962
    • Barrett, J.C.1    Hansoul, S.2    Nicolae, D.L.3    Cho, J.H.4    Duerr, R.H.5    Rioux, J.D.6
  • 12
    • 48349122755 scopus 로고    scopus 로고
    • Gene-centric association mapping of chromosome 3p implicates MST1 in IBD pathogenesis
    • Goyette P, Lefebvre C, Ng A, Brant SR, Cho JH, Duerr RH et al. Gene-centric association mapping of chromosome 3p implicates MST1 in IBD pathogenesis. Mucosal Immunol 2008; 1: 131-138.
    • (2008) Mucosal Immunol , vol.1 , pp. 131-138
    • Goyette, P.1    Lefebvre, C.2    Ng, A.3    Brant, S.R.4    Cho, J.H.5    Duerr, R.H.6
  • 14
    • 78651227093 scopus 로고    scopus 로고
    • Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci
    • Melum E, Franke A, Schramm C, Weismuller TJ, Gotthardt DN, Offner FA et al. Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci. Nat Genet 2011; 43: 17-19.
    • (2011) Nat Genet , vol.43 , pp. 17-19
    • Melum, E.1    Franke, A.2    Schramm, C.3    Weismuller, T.J.4    Gotthardt, D.N.5    Offner, F.A.6
  • 15
    • 80051483002 scopus 로고    scopus 로고
    • Distinct and overlapping genetic loci in Crohn's disease and ulcerative colitis: Correlations with pathogenesis
    • Waterman M, Xu W, Stempak JM, Milgrom R, Bernstein CN, Griffiths AM et al. Distinct and overlapping genetic loci in Crohn's disease and ulcerative colitis: correlations with pathogenesis. Inflamm Bowel Dis 2011; 17: 1936-1942.
    • (2011) Inflamm Bowel Dis , vol.17 , pp. 1936-1942
    • Waterman, M.1    Xu, W.2    Stempak, J.M.3    Milgrom, R.4    Bernstein, C.N.5    Griffiths, A.M.6
  • 16
    • 0032486243 scopus 로고    scopus 로고
    • Mode of receptor binding and activation by plasminogen-related growth factors
    • DOI 10.1016/S0014-5793(98)00533-X, PII S001457939800533X
    • Miller M, Leonard EJ. Mode of receptor binding and activation by plasminogenrelated growth factors. FEBS Lett 1998; 429: 1-3. (Pubitemid 28281234)
    • (1998) FEBS Letters , vol.429 , Issue.1 , pp. 1-3
    • Miller, M.1    Leonard, E.J.2
  • 17
    • 0027204250 scopus 로고
    • Cloning, sequencing, and expression of human macrophage stimulating protein (MSP, MST1) confirms MSP as a member of the family of kringle proteins and locates the MSP gene on chromosome 3
    • Yoshimura T, Yuhki N, Wang M, Skeel A, Leonard EJ. Cloning, sequencing, and expression of human macrophage stimulating protein (MSP, MST1) confirms MSP as a member of the family of kringle proteins and locates the MSP gene on chromosome 3. J Biol Chem 1993; 268: 15461-15468. (Pubitemid 23222036)
    • (1993) Journal of Biological Chemistry , vol.268 , Issue.21 , pp. 15461-15468
    • Yoshimura, T.1    Yuhki, N.2    Wang, M.-H.3    Skeel, A.4    Leonard, E.J.5
  • 18
    • 18744410346 scopus 로고    scopus 로고
    • Macrophage-stimulating protein and RON receptor tyrosine kinase: Potential regulators of macrophage inflammatory activities
    • Wang MH, Zhou YQ, Chen YQ. Macrophage-stimulating protein and RON receptor tyrosine kinase: potential regulators of macrophage inflammatory activities. Scand J Immunol 2002; 56: 545-553.
    • (2002) Scand J Immunol , vol.56 , pp. 545-553
    • Wang, M.H.1    Zhou, Y.Q.2    Chen, Y.Q.3
  • 19
    • 0027957058 scopus 로고
    • Proteolytic conversion of single chain precursor macrophage-stimulating protein to a biologically active heterodimer by contact enzymes of the coagulation cascade
    • Wang M, Yoshimura T, Skeel A, Leonard EJ. Proteolytic conversion of single chain precursor macrophage-stimulating protein to a biologically active heterodimer by contact enzymes of the coagulation cascade. J Biol Chem 1994; 269: 3436-3440. (Pubitemid 24237662)
    • (1994) Journal of Biological Chemistry , vol.269 , Issue.5 , pp. 3436-3440
    • Wang, M.-H.1    Yoshimura, T.2    Skeel, A.3    Leonard, E.J.4
  • 20
    • 0028567137 scopus 로고
    • Molecular evolution and domain structure of plasminogen-related growth factors (HGF/SF and HGF1/MSP)
    • Donate LE, Gherardi E, Srinivasan N, Sowdhamini R, Aparicio S, Blundell TL. Molecular evolution and domain structure of plasminogen-related growth factors (HGF/SF and HGF1/MSP). Prot Sci 1994; 3: 2378-2394.
    • (1994) Prot Sci , vol.3 , pp. 2378-2394
    • Donate, L.E.1    Gherardi, E.2    Srinivasan, N.3    Sowdhamini, R.4    Aparicio, S.5    Blundell, T.L.6
  • 21
    • 0025938869 scopus 로고
    • Characterization of the DNF15S2 locus on human chromosome 3: Identification of a gene coding for four kringle domains with homology to hepatocyte growth factor
    • Han S, Stuart LA, Degen SJ. Characterization of the DNF15S2 locus on human chromosome 3: identification of a gene coding for four kringle domains with homology to hepatocyte growth factor. Biochemistry 1991; 30: 9768-9780.
    • (1991) Biochemistry , vol.30 , pp. 9768-9780
    • Han, S.1    Stuart, L.A.2    Degen, S.J.3
  • 23
    • 0029618773 scopus 로고
    • The proto-oncogene RON is involved in development of epithelial, bone and neuro-endocrine tissues
    • Gaudino G, Avantaggiato V, Follenzi A, Acampora D, Simeone A, Comoglio PM. The proto-oncogene RON is involved in development of epithelial, bone and neuro-endocrine tissues. Oncogene 1995; 11: 2627-2637. (Pubitemid 26023831)
    • (1995) Oncogene , vol.11 , Issue.12 , pp. 2627-2637
    • Gaudino, G.1    Avantaggiato, V.2    Follenzi, A.3    Acampora, D.4    Simeone, A.5    Comoglio, P.M.6
  • 24
    • 0028845666 scopus 로고
    • Restricted expression of the RON gene encoding the macrophage stimulating protein receptor during mouse development
    • Quantin B, Schuhbaur B, Gesnel M, Dollé P, Breathnach R. Restricted expression of the RON gene encoding the macrophage stimulating protein receptor during mouse development. Am J Anat 1995; 204: 383-390.
    • (1995) Am J Anat , vol.204 , pp. 383-390
    • Quantin, B.1    Schuhbaur, B.2    Gesnel, M.3    Dollé, P.4    Breathnach, R.5
  • 25
    • 0028874987 scopus 로고
    • Terminal differentiation of murine resident peritoneal macrophages is characterized by expression of the STK protein tyrosine kinase, a receptor for macrophagestimulating protein
    • Iwama A, Wang MH, Yamaguchi N, Ohno N, Okano K, Sudo T et al. Terminal differentiation of murine resident peritoneal macrophages is characterized by expression of the STK protein tyrosine kinase, a receptor for macrophagestimulating protein. Blood 1995; 86: 3394-3403.
    • (1995) Blood , vol.86 , pp. 3394-3403
    • Iwama, A.1    Wang, M.H.2    Yamaguchi, N.3    Ohno, N.4    Okano, K.5    Sudo, T.6
  • 26
    • 0029933168 scopus 로고    scopus 로고
    • Macrophage-stimulating protein activates STK receptor tyrosine kinase on osteoclasts and facilitates bone resorption by osteoclast-like cells
    • Kurihara N, Iwama A, Tatsumi J, Ikeda K, Suda T. Macrophage-stimulating protein activates STK receptor tyrosine kinase on osteoclasts and facilitates bone resorption by osteoclast-like cells. Blood 1996; 87: 3704-3710. (Pubitemid 26129598)
    • (1996) Blood , vol.87 , Issue.9 , pp. 3704-3710
    • Kurihara, N.1    Iwama, A.2    Tatsumi, J.3    Ikeda, K.4    Suda, T.5
  • 27
    • 0032741542 scopus 로고    scopus 로고
    • Negative regulation of macrophage activation in response to IFN-g and lipopolysaccharide by the STK/RON receptor tyrosine kinase
    • Liu Q, Fruit K, Ward J, Correll PH. Negative regulation of macrophage activation in response to IFN-g and lipopolysaccharide by the STK/RON receptor tyrosine kinase. J Immunol 1999; 163: 6606-6613.
    • (1999) J Immunol , vol.163 , pp. 6606-6613
    • Liu, Q.1    Fruit, K.2    Ward, J.3    Correll, P.H.4
  • 28
    • 0031683197 scopus 로고    scopus 로고
    • Proteolytic cleavage and activation of pro-macrophage-stimulating protein and upregulation of its receptor in tissue injury
    • DOI 10.1046/j.1523-1747.1998.00332.x
    • Nanney LB, Skeel A, Luan J, Polis S, Richmond A, Wang MH et al. Proteolytic cleavage and activation of pro-macrophage-stimulating protein and upregulation of its receptor in tissue injury. J Invest Dermatol 1998; 111: 573-581. (Pubitemid 28452315)
    • (1998) Journal of Investigative Dermatology , vol.111 , Issue.4 , pp. 573-581
    • Nanney, L.B.1    Skeel, A.2    Luan, J.3    Polis, S.4    Richmond, A.5    Wang, M.-H.6    Leonard, E.J.7
  • 29
    • 0029802366 scopus 로고    scopus 로고
    • Induction of met proto-oncogene (hepatocyte growth factor receptor) expression during human monocyte-macrophage differentiation
    • Chen Q, DeFrances MC, Zarnegar R. Induction of met proto-oncogene (hepatocyte growth factor receptor) expression during human monocytemacrophage differentiation. Cell Growth Differ 1996; 7: 821-832. (Pubitemid 26360750)
    • (1996) Cell Growth and Differentiation , vol.7 , Issue.6 , pp. 821-832
    • Chen, Q.1    DeFrances, M.C.2    Zarnegar, R.3
  • 30
    • 79952195585 scopus 로고    scopus 로고
    • Metaanalysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
    • Anderson CA, Boucher G, Lees CW, Franke A, D'Amato M, Taylor KD et al. Metaanalysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat Genet 2011; 43: 246-252.
    • (2011) Nat Genet , vol.43 , pp. 246-252
    • Anderson, C.A.1    Boucher, G.2    Lees, C.W.3    Franke, A.4    D'Amato, M.5    Taylor, K.D.6
  • 32
    • 33745536739 scopus 로고    scopus 로고
    • Functional consequences of NOD2 (CARD15) mutations
    • DOI 10.1097/01.MIB.0000225332.83861.5f, PII 0005472520060700000014
    • Abraham C, Cho JH. Functional consequences of NOD2 (CARD15) mutations. Inflamm Bowel Dis 2006; 12: 641-650. (Pubitemid 43977746)
    • (2006) Inflammatory Bowel Diseases , vol.12 , Issue.7 , pp. 641-650
    • Abraham, C.1    Cho, J.H.2
  • 35
    • 0028240846 scopus 로고
    • Increased macrophage subset in inflammatory bowel disease: Apparent recruitment from peripheral blood monocytes
    • Rugtveit J, Brandtzaeg P, Halstensen TS, Fausa O, Scott H. Increased macrophage subset in inflammatory bowel disease: apparent recruitment from peripheral blood monocytes. Gut 1994; 35: 669-674. (Pubitemid 24163796)
    • (1994) Gut , vol.35 , Issue.5 , pp. 669-674
    • Rugtveit, J.1    Brandtzaeg, P.2    Halstensen, T.S.3    Fausa, O.4    Scott, H.5
  • 38
    • 70949087383 scopus 로고    scopus 로고
    • Inflammatory bowel disease and mutations affecting the interleukin-10 receptor
    • Glocker E, Kotlarz D, Boztug K, Gertz EM, Schà ffer AA, Noyan F et al. Inflammatory bowel disease and mutations affecting the interleukin-10 receptor. N Engl J Med 2009; 361: 2033-2045.
    • (2009) N Engl J Med , vol.361 , pp. 2033-2045
    • Glocker, E.1    Kotlarz, D.2    Boztug, K.3    Gertz, E.M.4    Schãffer, A.A.5    Noyan, F.6
  • 40
    • 1642443959 scopus 로고    scopus 로고
    • Macrophage-stimulating protein, the ligand for the stem cell-derived tyrosine kinase/RON receptor tyrosine kinase, inhibits IL-12 production by primary peritoneal macrophages stimulated with IFN-gamma and lipopolysaccharide
    • Morrison AC, Wilson CB, Ray M, Correll PH. Macrophage-stimulating protein, the ligand for the stem cell-derived tyrosine kinase/RON receptor tyrosine kinase, inhibits IL-12 production by primary peritoneal macrophages stimulated with IFN-gamma and lipopolysaccharide. J Immunol 2004; 172: 1825-1832. (Pubitemid 38116831)
    • (2004) Journal of Immunology , vol.172 , Issue.3 , pp. 1825-1832
    • Morrison, A.C.1    Wilson, C.B.2    Ray, M.3    Correll, P.H.4
  • 41
    • 45749101727 scopus 로고    scopus 로고
    • H17 cells
    • DOI 10.1038/nature07036, PII NATURE07036
    • Bettelli E, Korn T, Oukka M, Kuchroo VK. Induction and effector functions of TH17 cells. Nature 2008; 453: 1051-1057. (Pubitemid 351871737)
    • (2008) Nature , vol.453 , Issue.7198 , pp. 1051-1057
    • Bettelli, E.1    Korn, T.2    Oukka, M.3    Kuchroo, V.K.4
  • 43
    • 0033569877 scopus 로고    scopus 로고
    • Interaction of macrophage-stimulating protein with its receptor
    • Danilkovitch A, Miller M, Leonard EJ. Interaction of macrophage- stimulating protein with its receptor. J Biol Chem 1999; 274: 29937-29943.
    • (1999) J Biol Chem , vol.274 , pp. 29937-29943
    • Danilkovitch, A.1    Miller, M.2    Leonard, E.J.3
  • 45
    • 1842430894 scopus 로고    scopus 로고
    • A combination of proteomics, principal component analysis and transcriptomics is a powerful tool for the identification of biomarkers for macrophage maturation in the U937 cell line
    • DOI 10.1002/pmic.200300669
    • Verhoeckx KCM, Bijlsma S, de Groene EM, Witkamp RF, van der Greef J, Rodenburg RJT. A combination of proteomics, principal component analysis and transcriptomics is a powerful tool for the identification of biomarkers for macrophage maturation in the U937 cell line. Proteomics 2004; 4: 1014-1028. (Pubitemid 38450707)
    • (2004) Proteomics , vol.4 , Issue.4 , pp. 1014-1028
    • Verhoeckx, K.C.M.1    Bijlsma, S.2    De Groene, E.M.3    Witkamp, R.F.4    Van Der Greef, J.5    Rodenburg, R.J.T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.