Monoclonal gammopathy related to Sjögren syndrome: A key marker of disease prognosis and outcomes

Journal of Autoimmunity

Volumn 39, Issue 1-2, 2012, Pages 43-48

  Brito Zerón, Pilar ^a   Retamozo, Soledad ^a   Gandía, Myriam ^b   Akasbi, Miriam ^c   Pérez De Lis, Marta ^d   Diaz Lagares, Candido ^a   Bosch, Xavier ^a   Bové, Albert ^a   Pérez Alvarez, Roberto ^d   Soto Cárdenas, María José ^b   Sisó, Antoni ^a   Ramos Casals, Manuel ^a  

^a INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

^b HOSPITAL UNIVERSITARIO PUERTA DEL MAR   (Spain)

^c HOSPITAL UNIVERSITARIO INFANTA LEONOR   (Spain)

^d HOSPITAL DO MEIXOEIRO   (Spain)

Author keywords

Cryoglobulinemia; Lymphoma; Monoclonal gammopathy; Mortality; Primary Sj gren syndrome

Indexed keywords

CRYOGLOBULIN; IMMUNOGLOBULIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN KAPPA CHAIN; IMMUNOGLOBULIN LAMBDA CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; IMMUNOGLOBULIN M; MONOCLONAL ANTIBODY; RHEUMATOID FACTOR;

ADULT; AGED; ARTICLE; BLOOD SAMPLING; CLINICAL ASSESSMENT; CONTROLLED STUDY; CRYOGLOBULINEMIA; DIAGNOSTIC TEST ACCURACY STUDY; DISEASE ASSOCIATION; DISEASE MARKER; ERYTHROCYTE SEDIMENTATION RATE; EUROPE; FEMALE; FOLLOW UP; GENE EXPRESSION; HEMATOLOGIC MALIGNANCY; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; IMMUNOELECTROPHORESIS; IMMUNOGLOBULIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; MONOCLONAL IMMUNOGLOBULINEMIA; NEUROLOGIC DISEASE; OUTCOME ASSESSMENT; PAROTID GLAND DISEASE; PAROTIDOMEGALY; PREDICTIVE VALUE; PREVALENCE; PRIORITY JOURNAL; PROGNOSIS; RISK FACTOR; SENSITIVITY AND SPECIFICITY; SJOEGREN SYNDROME; SURVIVAL RATE; VASCULITIS;

ANTIBODIES, MONOCLONAL; BIOLOGICAL MARKERS; CRYOGLOBULINEMIA; FEMALE; HEPATITIS C; HUMANS; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN KAPPA-CHAINS; IMMUNOGLOBULIN LAMBDA-CHAINS; IMMUNOGLOBULIN M; MALE; MIDDLE AGED; PARAPROTEINEMIAS; PROGNOSIS; SJOGREN'S SYNDROME; TREATMENT OUTCOME;

EID: 84861689991     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2012.01.010     Document Type: Article

References (43)

1. Moutsopoulos H.M. Sjögren's syndrome: autoimmune epithelitis. Clin Immunol Immunopathol 1994, 72:162-165.
2. Ramos-Casals M., Tzioufas A.G., Font J. Primary Sjögren's syndrome: new clinical and therapeutic concepts. Ann Rheum Dis 2005, 64:347-354.
3. Brito-Zerón P., Ramos-Casals M. Prognosis of patients with primary Sjögren's syndrome. Med Clin (Barc) 2008, 130:109-115.
4. Madan S., Greipp P.R. The incidental monoclonal protein: current approach to management of monoclonal gammopathy of undetermined significance (MGUS). Blood Rev 2009, 23:257-265.
5. Kyle R.A., Therneau T.M., Rajkumar S.V., Offord J.R., Larson D.R., Plevak M.F., et al. A long-term study of prognosis in monoclonal gammopathy of undetermined significance. N Engl J Med 2002, 346:564-569.
6. Kyle R.A., Therneau T.M., Rajkumar S.V., Remstein E.D., Offord J.R., Larson D.R., et al. Long-term follow-up of IgM monoclonal gammopathy of undetermined significance. Blood 2003, 102:3759-3764.
7. Kyle R.A., Therneau T.M., Rajkumar S.V., Larson D.R., Plevak M.F., Offord J.R., et al. Prevalence of monoclonal gammopathy of undetermined significance. N Engl J Med 2006, 354:1362-1369.
8. Iwanaga M., Tagawa M., Tsukasaki K., Kamihira S., Tomonaga M. Prevalence of monoclonal gammopathy of undetermined significance. Study of 52,802 persons in Nagasaki City, Japan. Mayo Clin Proc 2007, 82:1474-1479.
9. Kyle R.A., Finkelstein S., Elveback L.R., Kurland L.T. Incidence of monoclonal proteins in a Minnesota community with a cluster of multiple myeloma. Blood 1972, 40:719-724.
10. Saleun J.P., Vicariot M., Deroff P., Morin J.F. Monoclonal gammopathies in the adult population of Finistere, France. J Clin Pathol 1982, 35:63-68.
11. Axelsson U., Bachmann R., Hallen J. Frequency of pathological proteins (M-components) om 6,995 sera from an adult population. Acta Med Scand 1966, 179:235-247.
12. Berenson J.R., Anderson K.C., Audell R.A., Boccia R.V., Coleman M., Dimopoulos M.A., et al. Monoclonal gammopathy of undetermined significance: a consensus statement. Br J Haematol 2010, 150:28-38.
13. Landgren O. Monoclonal gammopathy of undetermined significance and smoldering myeloma: new insights into pathophysiology and epidemiology. Hematol Am Soc Hematol Educ Program 2010, 2010:295-302.
14. Ramos-Casals M, Stone JH, Cid MC, Bosch X. The cryoglobulinaemias. Lancet 2011 Aug 23. [Epub ahead of print].
15. Ramos-Casals M., Font J. Primary Sjögren syndrome. Current diagnosis & treatment in rheumatology 2007, 237-245. McGraw-Hill, New York. J. Imboden, D. Hellman, J.H. Stone (Eds.).
16. Moutsopoulos H.M., Steinberg A.D., Fauci A.S., Lane H.C., Papadopoulos N.M. High incidence of free monoclonal lambda light chains in the sera of patients with Sjogren's syndrome. J Immunol 1983, 130:2663-2665.
17. Moutsopoulos H.M., Costello R., Drosos A.A., Mavridis A.K., Papadopoulos N.M. Demonstration and identification of monoclonal proteins in the urine of patients with Sjögren's syndrome. Ann Rheum Dis 1985, 44:109-112.
18. Tzioufas A.G., Costello R., Manoussakis M.N., Papadopoulos N.M., Moutsopoulos H.M. Cryoglobulinemia in primary Sjögren's syndrome: a monoclonal process. Scand J Rheumatol Suppl 1986, 61:111-113.
19. Tzioufas A.G., Manoussakis M.N., Costello R., Silis M., Papadopoulos N.M., Moutsopoulos H.M. Cryoglobulinemia in autoimmune rheumatic diseases. Evidence of circulating monoclonal cryoglobulins in patients with primary Sjögren's syndrome. Arthritis Rheum 1986, 29:1098-1104.
20. Brito-Zerón P., Ramos-Casals M., Nardi N., Cervera R., Yagüe J., Ingelmo M., et al. Circulating monoclonal immunoglobulins in Sjögren syndrome: prevalence and clinical significance in 237 patients. Medicine (Baltimore) 2005, 84:90-97.
21. Seror R., Mariette X., Bowman S., Baron G., Gottenberg J.E., Boostma H., et al. European league against rheumatism Sjögren's task force. Accurate detection of changes in disease activity in primary Sjögren's syndrome by the european league against rheumatism Sjögren's syndrome disease activity index. Arthritis Care Res (Hoboken) 2010, 62:551-558.
22. Vitali C., Bombardieri S., Jonsson R., Moutsopoulos H.M., Alexander E.L., Carsons S.E., et al. European study group on classification criteria for Sjögren's syndrome. Classification criteria for Sjögren's syndrome: a revised version of the European criteria proposed by the American-European consensus group. Ann Rheum Dis 2002, 61:554-558.
23. Vitali C., Bombardieri S., Moutsopoulos H.M., Balestrieri G., Bencivelli W., Bernstein R.M., et al. Preliminary criteria for the classification of Sjogren's syndrome. Results of a prospective concerted action supported by the European community. Arthritis Rheum 1993, 36:340-347.
24. Ramos-Casals M., De Vita S., Tzioufas A.G. Hepatitis C virus, Sjögren's syndrome and B-cell lymphoma: linking infection, autoimmunity and cancer. Autoimmun Rev 2005, 4:8-15.
25. Ramos-Casals M., Solans R., Rosas J., Camps M.T., Gil A., Del Pino-Montes J., et al. GEMESS study group. Primary Sjögren syndrome in Spain: clinical and immunologic expression in 1010 patients. Medicine (Baltimore) 2008, 87:210-219.
26. Swerdlow S.H., Campo E., Harris N.L., Jaffe E.S., Pileri S.A., Stein H., et al. WHO classification of tumours of haematopoietic and lymphoid tissues 2008, WHO, Lyon. 4th ed.
27. Waldenstrom J. Studies on conditions associated with disturbed gamma globulin formation (gammopathies). Harvey Lect 1960, 56:211-231.
28. Kyle R.A. Monoclonal gammopathy of undetermined significance. Natural history in 241 cases. Am J Med 1978, 64:814-826.
29. Kyle R.A., Durie B.G., Rajkumar S.V., Landgren O., Blade J., Merlini G., et al. Monoclonal gammopathy of undetermined significance (MGUS) and smoldering (asymptomatic) multiple myeloma: IMWG consensus perspectives risk factors for progression and guidelines for monitoring and management. Leukemia 2010, 24:1121-1127.
30. Zulman J., Jaffe R., Talal N. Evidence that the malignant lymphoma of Sjögren's syndrome is a monoclonal B-cell neoplasm. N Engl J Med 1978, 299:1215-1220.
31. Katsikis P.D., Youinou P.Y., Galanopoulou V., Papadopoulos N.M., Tzioufas A.G., Moutsopoulos H.M. Monoclonal process in primary Sjögren's syndrome and cross-reactive idiotype associated with rheumatoid factor. Clin Exp Immunol 1990, 82:509-514.
32. Tzioufas A.G., Katsikis P.D., Youinou P.Y., Moutsopoulos H.M. Sjögren's syndrome: an oligo-monoclonal B cell process. Clin Exp Rheumatol 1990, 8(Suppl 5):17-21.
33. Sugai S., Shimizu S., Konda S. Lymphoproliferative disorders in Japanese patients with Sjogren's syndrome. Scand J Rheumatol Suppl 1986, 61:118-122.
34. Walters M.T., Stevenson F.K., Herbert A., Cawley M.I., Smith J.L. Lymphoma in Sjogren's syndrome: urinary monoclonal free light chains as a diagnostic aid and a means of tumour monitoring. Scand J Rheumatol Suppl 1986, 61:114-117.
35. Varettoni M., Corso A., Cocito F., Mangiacavalli S., Pascutto C., Zappasodi P., et al. Changing pattern of presentation in monoclonal gammopathy of undetermined significance: a single-center experience with 1400 patients. Medicine (Baltimore) 2010, 89:211-216.
36. Youinou P., Papadopoulos N.M., Katsikis P., Pennec Y.L., Jouquan J., Lelong A., et al. Monoclonal immunoglobulins in the serum of patients with primary Sjogren's syndrome. Clin Exp Rheumatol 1988, 6:247-252.
37. Moutsopoulos H.M., Tzioufas A.G., Bai M.K., Papadopoulos N.M., Papadimitriou C.S. Association of serum IgM kappa monoclonicity in patients with Sjögren's syndrome with an increased proportion of kappa positive plasma cells infiltrating the labial minor salivary glands. Ann Rheum Dis 1990, 49:929-931.
38. Sibilia J., Cohen-Solal J. Prevalence of monoclonal gammopathy and myeloma in a cohort of primary Sjögren'syndrome. Arthritis Rheum 1999, 42(Suppl 9):S140. (abstract).
39. Andreone P., Zignego A.L., Cursaro C., Gramenzi A., Gherlinzoni F., Fiorino S., et al. Prevalence of monoclonal gammopathies in patients with hepatitis C virus infection. Ann Intern Med 1998, 129:294-298.
40. Boudart D., Lucas J.C., Muller J.Y., Le Carrer D., Planchon B., Harousseau J.L. False positive hepatitis C virus antibody tests in paraproteinaemia. Lancet 1990, 336:63.
41. Marson P., Vicarioto M., De Silvestro G., Tenderini M.L., Nardo G., Ongaro G. Anti hepatitis C virus antibodies in monoclonal gammopathy: an appraisal using the second generation tests. Haematologica 1992, 77:188.
42. Silvestri F., Barillari G., Fanin R., Zaja F., Infanti L., Patriarca F., et al. Risk of hepatitis C virus infection, Waldenstrom's macroglobulinemia, and monoclonal gammopathies. Blood 1996, 88:1125-1126.
43. De Re V., De Vita S., Gasparotto D., Marzotto A., Carbone A., Ferraccioli G., et al. Salivary gland B cell lymphoproliferative disorders in Sjogren's syndrome present a restricted use of antigen receptor gene segments similar to those used by hepatitis C virus-associated non Hodgkin's lymphomas. Eur J Immunol 2002, 32:903-910.