Albendazole causes stage-dependent developmental toxicity and is deactivated by a mammalian metabolization system in a modified zebrafish embryotoxicity test

Reproductive Toxicology

Volumn 34, Issue 1, 2012, Pages 31-42

  Mattsson, Anna ^a   Ullerås, Erik ^b   Patring, Johan ^a   Oskarsson, Agneta ^a  

^a SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

Albendazole; Developmental toxicity; Malformations; Metabolism; Zebrafish

Indexed keywords

ALBENDAZOLE; DRUG METABOLITE; SULFONE; SULFOXIDE;

ANIMAL EXPERIMENT; ARTICLE; CHEMICAL ANALYSIS; CONTROLLED STUDY; DEVELOPMENTAL STAGE; DEVELOPMENTAL TOXICITY; DRUG EFFECT; DRUG METABOLISM; EMBRYO; EMBRYO DEVELOPMENT; EMBRYOTOXICITY; FERTILIZATION; MAMMAL; METABOLIC ACTIVATION SYSTEM; METABOLIC PARAMETERS; NONHUMAN; TOXICITY TESTING; ZEBRA FISH;

ALBENDAZOLE; ANIMALS; ANTHELMINTICS; EMBRYO, NONMAMMALIAN; EMBRYONIC DEVELOPMENT; HEAD; HEART; HEART DEFECTS, CONGENITAL; MICROSOMES, LIVER; RATS; STEROID 21-HYDROXYLASE; TAIL; ZEBRAFISH;

DANIO RERIO; MAMMALIA;

EID: 84861676079     PISSN: 08906238     EISSN: 18731708     Source Type: Journal    
DOI: 10.1016/j.reprotox.2012.02.007     Document Type: Article

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