Developmental toxicity of albendazole and its three main metabolites in zebrafish embryos

Reproductive Toxicology

Volumn 32, Issue 1, 2011, Pages 129-137

  Carlsson, Gunnar ^a   Patring, Johan ^a   Ullerås, Erik ^a   Oskarsson, Agneta ^a  

^a SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

Author keywords

Benzimidazole; Dechorionation; Embryotoxicity; Teratogenicity; Zebrafish

Indexed keywords

ALBENDAZOLE; ALBENDAZOLE 2 AMINOSULFONE; ALBENDAZOLE SULFONE; ALBENDAZOLE SULFOXIDE; DRUG METABOLITE; UNCLASSIFIED DRUG;

ARTICLE; BIOAVAILABILITY; CHEMICAL ANALYSIS; CONCENTRATION (PARAMETERS); CONGENITAL MALFORMATION; DRUG STRUCTURE; EMBRYO; EMBRYO DEATH; EMBRYOTOXICITY; FERTILIZATION; NONHUMAN; PRENATAL DRUG EXPOSURE; ZEBRA FISH;

ABNORMALITIES, DRUG-INDUCED; ALBENDAZOLE; ANIMALS; ANTHELMINTICS; EMBRYO CULTURE TECHNIQUES; EMBRYO, NONMAMMALIAN; EMBRYONIC DEVELOPMENT; TERATOGENS; ZEBRAFISH;

ANIMALIA; DANIO RERIO;

EID: 79960464801     PISSN: 08906238     EISSN: 18731708     Source Type: Journal    
DOI: 10.1016/j.reprotox.2011.05.015     Document Type: Article

References (23)

1. Haider B.A., Humayun Q., Bhutta Z.A. Effect of administration of anthelmintics for soil transmitted helmints during pregnancy. Cochrane Database of Systemic Reviews 2009, 2:1-20.
2. WHO, World Health Organization. WHO report of the informal consultation on hookworm infection and anaemia in girls and women (WHO/CTD/SIP/96.1). Geneva: World Health Organization; 1994.
3. de Silva N.R., Sirisena J.L.G.J., Gunasekera D.P.S., Ismail M.M., de Silva H.J. Effect of mebendazole therapy during pregnancy on birth outcome. Lancet 1999, 353:1145-1149.
4. Lacey E. Mode of action of benzimidazoles. Parasitol Today 1990, 6:112-115.
5. JECFA, Albendazole. In: JECFA food additives series 25. Prepared by the thirty-fourth meeting of the joints WHO/FAO expert committee on food additives, WHO, Geneva, 1989. p. 3-29.
6. Navarro M., Canut L., Carretero A., Cristofol C., Pérez-Aparicio F.J., Arboix M., et al. Developmental toxicity in rat fetuses exposed to the benzimidazole netobimin. Reprod Toxicol 1999, 13:295-302.
7. Pourgholami M.H., Szwajcer M., Chin M., Liauw W., Seef J., Galettis P., et al. Phase I clinical trial to determine maximum tolerated dose of oral albendazole in patients with advanced cancer. Cancer Chemother Pharmacol 2010, 65:597-605.
8. Rawden H.C., Kokwaro G.O., Ward S.A., Edwards G. Relative contribution of cytochromes P-450 and flavin-containing monoxygenases to the metabolism of albendazole by human liver microsomes. Br J Clin Pharmacol 2000, 49:313-322.
9. Cristòfol C., Navarro M., Franquelo C., Valladares J.E., Carretero A., Ruberte J., et al. Disposition of netobimin, albendazole and its metabolites in the pregnant rat: developmental toxicity. Toxicol Appl Pharmacol 1997, 144:56-61.
10. Capece B.P.S., Navarro M., Arcalis T., Castells G., Toribio L., Perez F., et al. Albendazole sulfoxide enantiomers in pregnant rats embryo concentrations and developmental toxicity. Vet J 2003, 165:266-275.
11. Teruel M.T., Felipe A.E., Solana H.D., Sallovitz J.M., Lanusse C.E. Placental and fetal toxicity of albendazole sulphoxide in Wistar rats. Vet Hum Toxicol 2003, 45:131-136.
12. Delatour P., Parish R.C., Gyurik R.J. Albendazole: a comparison of relay embryotoxicity with embryotoxicity of individual metabolites. Ann Rech Vet 1981, 12:159-167.
13. Zhang C., Willett C., Fremgen T. Zebrafish: an animal model for toxicological studies. Curr Protoc Toxicol 2003, 1.7.1-18.
14. Hill A.J., Teraoka H., Heideman W., Peterson R.E. Zebrafish as a model vertebrate for investigating chemical toxicity. Tox Sci 2005, 86:6-19.
15. McGrath P., Li C.Q. Zebrafish: a predictive model for assessing drug-induced toxicity. Drug Discov Today 2008, 13:394-401.
16. Carlsson G., Örn S., Larsson D.G.J. Effluent from bulk drug production is toxic to aquatic vertebrates. Environ Contam Toxicol 2009, 28:2656-2662.
17. Yang L., Ho N.Y., Alshut R., Legradi J., Weiss C., Reischl M., et al. Zebrafish embryos as models for embryotoxic and teratological effects of chemicals. Reprod Toxicol 2009, 28:245-253.
18. Selderslaghs I.W.T., Van Rompay A.R., De Coen W., Witters H.E. Development of a screening assay to identify teratogenic and embryotoxic chemicals using the zebrafish embryo. Reprod Toxicol 2009, 28:308-320.
19. Brannen K.C., Panzica-Kelly J.M., Danberry T.L., Augustine-Rauch K.A. Development of a zebrafish embryo teratogenicity assay and quantitative prediction model. Birth Defects Res B Dev Reprod Toxicol 2010, 89:66-77.
20. International Organization for Standardization (ISO). Water quality - determination of the acute lethal toxicity of substances to a freshwater fish [Brachydanio rerio Hamilton-Buchanan (Teleostei, Cyprinidae)]. Part 1. Static method; 1996. ISO 7346-1:1996.
21. Jansson C., Kreuger J. Multiresidue analysis of 95 pesticides at low nanogram/liter level in surface waters using online preconcentration and high performance liquid chromatography/tandem mass spectrometry. JAOAC Int 2010, 93:1-16.
22. Whittaker S.G., Faustman E.M. Effects of albendazole and albendazole sulfoxide on cultures of differentiating rodent embryonic cells. Toxicol Appl Pharmacol 1991, 109:73-84.
23. Rolin S., Souhaili-el Amri H., Batt A.M., Levy M., Bagrel D., Siest G. Study of the in vitro bioactivation of albendazole in human liver microsomes and hepatoma cell lines. Cell Biol Toxicol 1989, 5:1-14.