WWOX-mediated apoptosis in A549 cells mainly involves the mitochondrial pathway

Molecular Medicine Reports

Volumn 6, Issue 1, 2012, Pages 121-124

  Zhang, Ping ^a   Jia, Renbing ^a   Ying, Lei ^a   Liu, Bo ^a   Qian, Guanxiang ^a   Fan, Xianqun ^a   Ge, Shengfang ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Apoptosis; Mitochondrion; WW domain containing oxidoreductase

Indexed keywords

CYTOCHROME C; PLASMID DNA; PROCASPASE 3; PROCASPASE 9;

APOPTOSIS; ARTICLE; CANCER CELL; CELL STRAIN A549; CONTROLLED STUDY; ENZYME ACTIVATION; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN TISSUE; MITOCHONDRIAL GENE; MITOCHONDRION; PROTEIN SECRETION; WWOX GENE;

ADENOCARCINOMA; APOPTOSIS; CASPASE 3; CASPASE 9; CELL LINE, TUMOR; CELL PROLIFERATION; CYTOCHROMES C; ENZYME ACTIVATION; HUMANS; LUNG NEOPLASMS; MITOCHONDRIA; OXIDOREDUCTASES; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEINS;

EID: 84861651822     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2012.860     Document Type: Article

References (17)

1. Bednarek AK, Laflin KJ, Daniel RL, Liao Q, Hawkins KA and Aldaz CM: WWOX, a novel WW domain-containing protein mapping to human chromesome 16q23.3-24.1, a region frequentlly affected in breast cancer. Cancer Res: 60: 2140-2145, 2000. (Pubitemid 30225175)
2. Pluciennik E, Kusiñska R, Potemski P, Kubiak R, Kordek R and Bednarek AK: WWOX-the FRA16D cancer gene: expression correlation with breast cancer progression and prognosis. Eur J Surg Oncol 32: 153-157, 2006. (Pubitemid 43257115)
3. Paige AJ, Zucknick M, Janczar S, Paul J, Mein CA, Taylor KJ, Stewart M, Gourley C, Richardson S, Perren T, et al: WWOX tumour suppressor gene polymorphisms and ovarian cancer pathology and prognosis. Eur J Cancer 46: 818-825, 2010.
4. Cheng I, Levin AM, Tai YC, Plummer S, Chen GK, Neslund-Dudas C, Casey G, Rybicki BA and Witte JS: Copy number alterations in prostate tumors and disease aggressiveness. Genes Chromosomes Cancer 51: 66-76, 2012.
5. Aqeilan RI, Kuroki T, Pekarsky Y, Albagha O, Trapasso F, Baffa R, Huebner K, Edmonds P and Croce CM: Loss of WWOX expression in gastric carcinoma.Clin Cancer Res 10: 3053-3058, 2004. (Pubitemid 38619682)
6. Aderca I, Moser CD, Veerasamy M, Bani-Hani AH, Bonilla-Guerrero R, Ahmed K, Shire A, Cazanave SC, Montoya DP, Mettler TA, et al: The JNK inhibitor SP600129 enhances apoptosis of HCC cells induced by the tumor suppressor WWOX. J Hepatol 49: 373-383, 2008.
7. Kurek KC, Del Mare S, Salah Z, Abdeen S, Sadiq H, Lee SH, Gaudio E, Zanesi N, Jones KB, DeYoung B, et al: Frequent attenuation of the WWOX tumor suppressor in osteosarcoma is associated with increased tumorigenicity and aberrant RUNX2 expression. Cancer Res. 70:5577-5586, 2010.
8. Becker S, Markova B, Wiewrodt R, Hoffarth S, Hähnel PS, Pleiner S, Schmidt LH, Breitenbuecher F and Schuler M: Functional and clinical characterization of the putative tumor suppressor WWOX in non-small cell lung cancer. J Thorac Oncol 6: 1976-1983, 2011.
9. Nunez MI, Rosen DG, Ludes-Meyers JH, Abba MC, Kil H, Page R, Klein-Szanto AJ, Godwin AK, Liu J, Mills GB et al: WWOX protein expression varies among ovarian carcinoma histotypes and correlates with less favorable outcome.BMC Cancer 5: 64, 2005.
10. Yendamuri S, Kuroki T, Trapasso F, Henry AC, Dumon KR, Huebner K, Williams NN, Kaiser LR and Croce CM: WW domain containing oxidreductase gene expression is altered in non-small cell lung cancer. Cancer Res 63: 878-881,2003. (Pubitemid 36231991)
11. Chang NS, Pratt N, Heath J, Schultz L, Sleve D, Carey GB and Zevotek N: Hyaluronidase induction of a WW domain-containing oxidoreductase that enhances tumor necrosis factor cytotoxicity. J Biol Chem 276: 3361-3370, 2001.
12. Chang NS, Doherty J, Ensign A, Lewis J, Heath J, Schultz L, Chen ST and Oppermann U: Molecular mechanism underlying WOX1 activation during apoptotic and stress responses. Biochem Pharmacol 66: 1347-1354, 2003. (Pubitemid 38379588)
13. Chang NS:A potential role for p53 and WOX1 in mitochondrial apoptosis. Int J Mol Med 9: 19-24, 2002.
14. Oppermann UC, Filling C and Jornvall H: Forms and functions of human SDR enzymes. Chem Biol Interact 30: 669-705, 2001.
15. Zhu J, Zhang S, Jiang J and Chen X: Definition of the p53 functional domains necessary for inducing apoptosis. J Biol Chem 275: 39927-39934, 2000. (Pubitemid 32064614)
16. Zhang P, Ying L, Xu R, Ge S, Mei W, Li F, Dai B, Lu J and Qian G: Tumor-specific, hypoxia-regulated, WW domain-containing oxidoreductase- expressing adenovirus inhibits human non-small cell lung cancer growth in vivo. Hum Gene Ther 21: 27-39, 2010.
17. Chang NS, Doherty J and Ensign A: JNK1 physically interacts with WW domain-containing oxidoreductase(WOX1) and inhibits WOX1-mediated apoptosis. J Biol Chem 278: 9195-9202, 2003. (Pubitemid 36800401)