Alternaria fungus induces the production of GM-CSF, interleukin-6 and interleukin-8 and calcium signaling in human airway epithelium through protease-activated receptor 2

International Archives of Allergy and Immunology

Volumn 158, Issue SUPPL. 1, 2012, Pages 19-29

  Matsuwaki, Yoshinori ^a,b   Wada, Kota ^a,b   White, Thomas ^a   Moriyama, Hiroshi ^b   Kita, Hirohito ^a  

^a MAYO CLINIC   (United States)

^b JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Airway epithelium; Alternaria; Aspartate protease; Fungi; Protease activated receptor 2

Indexed keywords

4 AMIDINOPHENYLMETHANESULFONYL FLUORIDE HYDROCHLORIDE; ALTERNARIA EXTRACT; ASPARTIC PROTEINASE; CALCIUM ION; EOTAXIN 2; FLUORIDE; FUNGAL EXTRACT; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HUMAN IMMUNODEFICIENCY VIRUS PROTEINASE INHIBITOR; INTERLEUKIN 6; INTERLEUKIN 8; PEPSTATIN; PROTEINASE ACTIVATED RECEPTOR 2; RANTES; UNCLASSIFIED DRUG;

AIRWAY; ALLERGY; ALTERNARIA; CALCIUM SIGNALING; CONCENTRATION (PARAMETERS); CONFERENCE PAPER; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVITY; EOSINOPHIL; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION;

ALTERNARIA; CALCIUM SIGNALING; CELL LINE; CYTOKINES; EOSINOPHILS; EPITHELIAL CELLS; EPITHELIUM; HUMANS; OLIGOPEPTIDES; PROTEASE INHIBITORS; RECEPTOR, PAR-2; RESPIRATORY SYSTEM;

EID: 84861648904     PISSN: 10182438     EISSN: 14230097     Source Type: Journal    
DOI: 10.1159/000337756     Document Type: Conference Paper

References (46)

1. Denning DW, O'Driscoll BR, Hogaboam CM, Bowyer P, Niven RM: The link between fungi and severe asthma: a summary of the evidence. Eur Respir J 2006; 27:615-626. (Pubitemid 43372538)
2. Bush RK, Prochnau JJ: Alternaria-induced asthma. J Allergy Clin Immunol 2004; 113: 227-234. (Pubitemid 38210542)
3. Zureik M, Neukirch C, Leynaert B, Liard R, Bousquet J, Neukirch F: Sensitisation to airborne moulds and severity of asthma: cross sectional study from European Community Respiratory Health Survey. BMJ 2002; 325: 411-414. (Pubitemid 34969788)
4. O'Hollaren MT, Yunginger JW, Offord KP, Somers MJ, O'Connell EJ, Ballard DJ, Sachs MI: Exposure to a n aeroallergen as a possible precipitating factor in respiratory arrest in young patients with asthma. N Engl J Med 1991; 324:359-363.
5. Salvaggio J, Seabury J, Schoenhardt FA: New Orleans Asthma. V. Relationship between Charity Hospital asthma admission rates, semiquantitative pollen and fungal spore counts, and total particulate aerometric sampling data. J Allergy Clin Immunol 1971; 48:96-114.
6. Diamond G, Legarda D, Ryan LK: The innate immune response of the respiratory epithelium. Immunol Rev 2000; 173:27-38. (Pubitemid 30095208)
7. Mayer AK, Dalpke AH: Regulation of local immunity by airway epithelial cells. Arch Immunol Ther Exp (Warsz) 2007; 55:353-362.
8. Moranta D, Regueiro V, March C, Llobet E, Margareto J, Larrarte E, Garmendia J, Ben-goechea JA: Klebsiella pneumoniae capsule polysaccharide impedes the expression of beta-defensins by airway epithelial cells. Infect Immun 2010; 78:1135-1146.
9. Reed CE, Kita H: The role of protease activation of inflammation in allergic respiratory diseases. J Allergy Clin Immunol 2004; 114: 997-1008;quiz 1009. (Pubitemid 39469133)
10. Knight DA, Lim S, Scaffidi AK, Roche N, Chung KF, Stewart GA, Thompson PJ: Pro-tease-activated receptors in human airways: upregulation of PAR-2 in respiratory epithelium from patients with asthma. J Allergy Clin Immunol 2001; 10 8: 797-803. (Pubitemid 33096213)
11. Kouzaki H, O'Grady SM, Lawrence CB, Kita H: Proteases induce production of thymic stromal lymphopoietin by airway epithelial cells through protease-activated receptor-2. J Immunol 2009; 183: 1427-1434.
12. Wang YH, Ito T, Homey B, Watanabe N, Martin R, Barnes CJ, McIntyre BW, Gilliet M, Kumar R, Yao Z, Liu YJ: Maintenance and polarization of human Th2 central memory T cells by thymic stromal lymphopoietin-ac-tivated dendritic cells. Immunity 2006; 24: 827-838. (Pubitemid 43867361)
13. Ying S, O'Connor B, Ratoff J, Meng Q, Mal-lett K, Cousins D, Robinson D, Zhang G, Zhao J, Lee TH, Corrigan C: Thymic stromal lymphopoietin expression is increased in asthmatic airways and correlates with expression of Th2-attracting chemokines and disease severity. J Immunol 2005; 174:8183-8190. (Pubitemid 40806330)
14. Kouzaki H, Iijima K, Kobayashi T, O'Grady SM, Kita H: The danger signal, extracellular ATP, is a sensor for an airborne allergen and triggers IL-33 release and innate Th2-type responses. J Immunol 2011; 186:4375-4387.
15. Matsuwaki Y, Wada K, White TA, Benson LM, Charlesworth MC, Checkel JL, Inoue Y, Hotta K, Ponikau JU, Lawrence CB, Kita H: Recognition of fungal protease activities induces cellular activation and eosinophil-de-rived neurotoxin release in human eosino-phils. J Immunol 2009; 18 3: 6708-6716.
16. Kauffman HF, Tomee JF, van de Riet MA, Timmerman AJ, Borger P: Protease-depen-dent activation of epithelial cells by fungal allergens leads to morphologic changes and cytokine production. J Allergy Clin Immunol 2000; 105:1185-1193. (Pubitemid 30418799)
17. Hansel TT, De Vries IJ, Iff T, Rihs S, Wand-zilak M, Betz S, Blaser K, Walker C: An improved immunomagnetic procedure for the isolation of highly purified human blood eo-sinophils. J Immunol Methods 1991; 145: 105-110.
18. Markwardt KL, Magnino PE, Pang IH: Effect of histamine on phosphoinositide turnover and intracellular calcium in human ciliary muscle cel ls. Exp Eye Res 1996; 62: 511-520.
19. + indicators with greatly improved fluorescence properties. J Biol Chem 1985; 260: 3440-3450. (Pubitemid 15114340)
20. Inoue Y, Matsuwaki Y, Shin SH, Ponikau JU, Kita H: Nonpathogenic, environmental fungi induce activation and degranulation of human eosinophils. J Immunol 2005; 175: 5439-5447. (Pubitemid 41456430)
21. Kernen P, Wymann MP, von Tscharner V, Deranleau DA, Tai PC, Spry CJ, Dahinden CA, Baggiolini M: Shape changes, exocyto-sis, and cytosolic free calcium changes in stimulated human eosinophils. J Clin Invest 1991; 87:2012-2017.
22. Yoon J, Ponikau JU, Lawrence CB, Kita H: Innate antifungal immunity of human eo-sinophils mediated by a beta 2 integrin, CD11B. J Immunol 2008; 181: 2907-2915.
23. Kato A, Schleimer RP: Beyond inflammation: Airway epithelial cells are at the interface of innate and adaptive immunity. Curr Opin Immunol 2007; 19: 711-720. (Pubitemid 350236807)
24. Saenz SA, Taylor BC, Artis D: Welcome to the neighborhood: epithelial cell-derived cy-tokines license innate and adaptive immune responses at mucosal sites. Immunol Rev 2008; 226: 17 2-19 0.
25. Vliagoftis H, Befus AD, Hollenberg MD, Moqbel R: Airway epithelial cells release eo-sinophil survival-promoting factors (GM-CSF) after stimulation of proteinase-activat-ed receptor 2. J Allergy Clin Immunol 2001; 107:679-685. (Pubitemid 32397757)
26. Asokananthan N, Graham PT, Fink J, Knight DA, Bakker AJ, McWilliam AS, Thompson PJ, Stewart GA: Activation of protease-acti-vated receptor (PAR)-1, PAR-2, and PAR-4 stimulates IL-6, IL-8, and prostaglandin E2 release from human respiratory epithelial cells. J Immunol 2002; 168:3577-3585. (Pubitemid 34250428)
27. Cocks TM, Fong B, Chow JM, Anderson GP, Frauman AG, Goldie RG, Henry PJ, Carr MJ, Hamilton JR, Moffatt JD: A protective role for protease-activated receptors in the airways. Nature 1999; 398: 156-160.
28. Vliagoftis H, Schwingshackl A, Milne CD, Duszyk M, Hollenberg MD, Wallace JL, Be-fus AD, Moqbel R: Proteinase-activated re-ceptor-2-mediated matrix metalloprotein-ase-9 release from airway epithelial cells. J Allerg y Clin Immunol 2000; 106: 537-5 45. (Pubitemid 32037707)
29. Matsukura S, Stellato C, Georas SN, Caso-laro V, Plitt JR, Miura K, Kurosawa S, Schindler U, Schleimer RP: Interleukin-13 upregulates eotaxin expression in airway epithelial cells by a STAT6-dependent mechanism. Am J Respir Cell Mol Biol 2001; 24: 755-761. (Pubitemid 32550599)
30. Tai PC, Spry CJ: The effects of recombinant granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-3 on the secretory capacity of human blood eo-sinophils. Clin Exp Immunol 1990; 80:426-434. (Pubitemid 20180340)
31. Hamilton JA: GM-CSF in inflammation and autoimmunity. Trends Immunol 2002; 23: 403-408. (Pubitemid 34804636)
32. Fleetwood AJ, Cook AD, Hamilton JA: Functions of granulocyte-macrophage colony-stimulating factor. Crit Rev Immunol 2005; 25:405-428. (Pubitemid 43068934)
33. Xing Z, Ohkawara Y, Jordana M, Graham F, Gauldie J: Transfer of granulocyte-macro-phage colony-stimulating factor gene to rat lung induces eosinophilia, monocytosis, and fibrotic reactions. J Clin Invest 1996; 97: 1102-1110. (Pubitemid 26070590)
34. Stampf li MR, Wiley RE, Neigh GS, Gajewska BU, Lei XF, Snider DP, Xing Z, Jordana M: GM-CSF transgene expression in the airway allows aerosolized ovalbumin to induce allergic sensitization in mice. J Clin Invest 1998; 102:1704-1714. (Pubitemid 28516255)
35. Ohtoshi T, Vancheri C, Cox G, Gauldie J, Do-lovich J, Denburg JA, Jordana M: Monocyte-macrophage differentiation induced by human upper airway epithelial cells. Am J Respir Cell Mol Biol 1991; 4:255-263.
36. Saha S, Doe C, Mistry V, Siddiqui S, Parker D, Sleeman M, Cohen ES, Brightling CE: Granulocyte-macrophage colony-stimulating factor expression in induced sputum and bronchial mucosa in asthma and COPD. Thorax 2009; 64:671-676.
37. Robinson DS, Hamid Q, Ying S, Tsicopoulos A, Barkans J, Bentley AM, Corrigan C, Durham SR, Kay AB: Predominant Th2-like bronchoalveolar T-lymphocyte population in atopic asthma. N Engl J Med 1992; 326: 298-304.
38. Doganci A, Sauer K, Karwot R, Finotto S: Patholog ica l role of IL-6 in the exper imental allergic bronchial asthma in mice. Clin Rev A l lerg y Immunol 2005; 28: 257-270.
39. Doganci A, Eigenbrod T, Krug N, De Sanctis GT, Hausding M, Erpenbeck VJ, Haddad el B, Lehr HA, Schmitt E, Bopp T, Kallen KJ, Herz U, Schmitt S, Luft C, Hecht O, Hohlfeld JM, Ito H, Nishimoto N, Yoshizaki K, Kishimoto T, Rose-John S, Renz H, Neurath MF, Galle PR, Finotto S: The IL-6R alpha chain controls lung CD4+CD25+ Treg development and function during allergic airway in-flammation in vivo. J Clin Invest 2005; 115: 313-325. (Pubitemid 40385473)
40. Rose-John S, Scheller J, Elson G, Jones SA: Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer. J Leukoc Biol 2006; 80:227-236. (Pubitemid 44835496)
41. Strieter RM: Interleukin-8: a very important chemokine of the human airway epithelium. Am J Physiol Lung Cell Mol Physiol 2002; 283:L688-689.
42. Kasahara T, Mukaida N, Yamashita K, Yagi-sawa H, Akahoshi T, Matsushima K: IL-1 and TNF-alpha induction of IL-8 and mono-cyte chemotactic and activating factor (MCAF) mRNA expression in a human as-trocytoma cell line. Immunology 1991; 74: 60-67.
43. Hobbie S, Chen LM, Davis RJ, Galan JE: Involvement of mitogen-activated protein ki-nase pathways in the nuclear responses and cytokine production induced by Salmonella typhimurium in cultured intestinal epi-thelia l cells. J Immunol 1997; 159: 5550-5559. (Pubitemid 127470084)
44. Johnston SL, Papi A, Bates PJ, Mastronarde JG, Monick MM, Hunninghake GW: Low grade rhinovirus infection induces a prolonged release of IL-8 in pulmonary epithelium. J Immunol 1998; 160:6172-6181. (Pubitemid 28298083)
45. Hirota R, Akimaru K, Nakamura H: In vitro toxicity evaluation of diesel exhaust particles on human eosinophilic cell. Toxicol In Vitro 2008; 22:988-994.
46. Fritz EA, Jacobs JJ, Glant TT, Roebuck KA: Chemokine IL-8 induction by particulate wea r debr is i n osteoblasts is mediated by NF-kappaB. J Or thop Res 2005; 23: 1249-1257. (Pubitemid 41554654)