Influence of antipsychotic agents on heart rate variability in male WKY rats: Implications for cardiovascular safety

Neuropsychobiology

Volumn 65, Issue 4, 2012, Pages 216-226

  Wang, Ying Chieh ^a,b   Chen, Chun Yu ^c   Kuo, Terry B J ^c,d   Lai, Ching Jung ^a   Yang, Cheryl C H ^c,d  

^a TZU CHI UNIVERSITY   (Taiwan)

^b YULI VETERANS HOSPITAL   (Taiwan)

^c NATIONAL YANG MING UNIVERSITY   (Taiwan)

^d TAIPEI CITY HOSPITAL   (Taiwan)

Author keywords

Antipsychotics; Autonomic activity; Cardiovascular safety; Heart rate variability; Schizophrenia

Indexed keywords

CLOZAPINE; HALOPERIDOL; NEUROLEPTIC AGENT; RISPERIDONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTONOMIC NERVOUS SYSTEM FUNCTION; CARDIOVASCULAR EFFECT; CONTROLLED STUDY; DRUG SAFETY; ELECTROENCEPHALOGRAPHY; ELECTROMYOGRAPHY; HEART FUNCTION; HEART RATE VARIABILITY; MALE; NONHUMAN; PARASYMPATHETIC TONE; PRIORITY JOURNAL; RAT; SLEEP; SLEEP PATTERN; SLEEP STAGE; SYMPATHETIC TONE;

ANALYSIS OF VARIANCE; ANIMALS; ANTIPSYCHOTIC AGENTS; BRAIN WAVES; ELECTROCARDIOGRAPHY; ELECTROENCEPHALOGRAPHY; ELECTROMYOGRAPHY; EVOKED POTENTIALS; EYE MOVEMENTS; HEART RATE; MALE; RATS; RATS, INBRED WKY; SLEEP;

EID: 84861647371     PISSN: 0302282X     EISSN: 14230224     Source Type: Journal    
DOI: 10.1159/000337459     Document Type: Article

References (50)

1. Zipes DP, Wellens HJ: Sudden cardiac death. Circulation 1998; 98: 2334-2351. (Pubitemid 28533855)
2. Ruschena D, Mullen PE, Burgess P, Cordner SM, Barry-Walsh J, Drummer OH, Palmer S, Browne C, Wallace C: Sudden death in psychiatric patients. Br J Psychiatry 1998; 172: 331-336. (Pubitemid 28183860)
3. Cao JM, Chen LS, KenKnight BH, Ohara T, Lee MH, Tsai J, Lai WW, Karagueuzian HS, Wolf PL, Fishbein MC, Chen PS: Nerve sprouting and sudden cardiac death. Circ Res 2000; 86: 816-821.
4. Rubart M, Zipes DP: Mechanisms of sudden cardiac death. J Clin Invest 2005; 115: 2305-2315. (Pubitemid 41266189)
5. Chen PS, Chen LS, Cao JM, Sharifi B, Karagueuzian HS, Fishbein MC: Sympathetic nerve sprouting, electrical remodeling and the mechanisms of sudden cardiac death. Cardiovasc Res 2001; 50: 409-416. (Pubitemid 32382168)
6. Bar KJ, Letzsch A, Jochum T, Wagner G, Greiner W, Sauer H: Loss of efferent vagal activity in acute schizophrenia. J Psychiatr Res 2005; 39: 519-527. (Pubitemid 40909996)
7. Fujibayashi M, Matsumoto T, Kishida I, Kimura T, Ishii C, Ishii N, Moritani T: Autonomic nervous system activity and psychiatric severity in schizophrenia. Psychiatry Clin Neurosci 2009; 63: 538-545.
8. Brown RP, Kocsis JH: Sudden death and antipsychotic drugs. Hosp Community Psychiatry 1984; 35: 486-491. (Pubitemid 14114325)
9. Mehtonen OP, Aranko K, Malkonen L, Vapaatalo H: A survey of sudden death associated with the use of antipsychotic or antidepressant drugs: 49 cases in Finland. Acta Psychiatr Scand 1991; 84: 58-64.
10. Ray WA, Meredith S, Thapa PB, Meador KG, Hall K, Murray KT: Antipsychotics and the risk of sudden cardiac death. Arch Gen Psychiatry 2001; 58: 1161-1167. (Pubitemid 33121508)
11. Ray WA, Chung CP, Murray KT, Hall K, Stein CM: Atypical antipsychotic drugs and the risk of sudden cardiac death. N Engl J Med 2009; 360: 225-235.
12. Kobayashi H, Ishibashi K, Noguchi H: Heart rate variability: an index for monitoring and analyzing human autonomic activities. Appl Human Sci 1999; 18: 53-59.
13. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology: Heart rate variability: standards of measurement, physiological interpretation and clinical use. Circulation 1996; 93: 1043-1065.
14. Algra A, Tijssen JG, Roelandt JR, Pool J, Lubsen J: Heart rate variability from 24-hour electrocardiography and the 2-year risk for sudden death. Circulation 1993; 88: 180-185. (Pubitemid 23195447)
15. Bikkina M, Alpert MA, Mukerji R, Mulekar M, Cheng BY, Mukerji V: Diminished short-term heart rate variability predicts inducible ventricular tachycardia. Chest 1998; 113: 312-316. (Pubitemid 28110003)
16. Singh JP, Larson MG, O'Donnell CJ, Wilson PF, Tsuji H, Lloyd-Jones DM, Levy D: Association of hyperglycemia with reduced heart rate variability (The Framingham Heart Study). Am J Cardiol 2000; 86: 309-312. (Pubitemid 30462227)
17. La Rovere MT, Bigger JT Jr, Marcus FI, Mortara A, Schwartz PJ: Baroreflex sensitivity and heart-rate variability in prediction of total cardiac mortality after myocardial infarction. ATRAMI (Autonomic Tone and Reflexes After Myocardial Infarction) Investigators. Lancet 1998; 351: 478-484. (Pubitemid 28070094)
18. Agelink MW, Majewski T, Wurthmann C, Lukas K, Ullrich H, Linka T, Klieser E: Effects of newer atypical antipsychotics on autonomic neurocardiac function: a comparison between amisulpride, olanzapine, sertindole, and clozapine. J Clin Psychopharmacol 2001; 21: 8-13. (Pubitemid 32096744)
19. Eschweiler GW, Bartels M, Langle G, Wild B, Gaertner I, Nickola M: Heart-rate variability (HRV) in the ECG trace of routine EEGs: fast monitoring for the anticholinergic effects of clozapine and olanzapine? Pharmacopsychiatry 2002; 35: 96-100. (Pubitemid 34651915)
20. Schotte A, Janssen PF, Gommeren W, Luyten WH, Van Gompel P, Lesage AS, De Loore K, Leysen JE: Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding. Psychopharmacology (Berl) 1996; 124: 57-73. (Pubitemid 26112775)
21. Tandon R: Neuropharmacologic basis for clozapine's unique profile. Arch Gen Psychiatry 1993; 50: 158-159.
22. Spierings EL, Dzoljic MR, Godschalk M: Effect of clozapine on the sleep pattern in the rat. Pharmacology 1977; 15: 551-556. (Pubitemid 8213200)
23. Dugovic C, Wauquier A, Janssen PA: Differential effects of the new antipsychotic risperidone on sleep and wakefulness in the rat. Neuropharmacology 1989; 28: 1431-1433. (Pubitemid 20008284)
24. Gimenez S, Clos S, Romero S, Grasa E, Morte A, Barbanoj MJ: Effects of olanzapine, risperidone and haloperidol on sleep after a single oral morning dose in healthy volunteers. Psychopharmacology (Berl) 2007; 190: 507-516. (Pubitemid 46204468)
25. Yang CCH, Shaw FZ, Lai CJ, Lai CW, Kuo TBJ: Relationship between electroencephalogram slow-wave magnitude and heart rate variability during sleep in rats. Neurosci Lett 2003; 336: 21-24. (Pubitemid 35454112)
26. Kuo TBJ, Lai CJ, Shaw FZ, Lai CW, Yang CCH: Sleep-related sympathovagal imbalance in SHR. Am J Physiol Heart Circ Physiol 2004; 286:H1170-H1176. (Pubitemid 38248634)
27. Kuo TBJ, Yang CCH: Sleep-related changes in cardiovascular neural regulation in spontaneously hypertensive rats. Circulation 2005; 112: 849-854. (Pubitemid 41170071)
28. Chen ML, Chen CH: Chronic antipsychotics treatment regulates MAOA, MAOB and COMT gene expression in rat frontal cortex. J Psychiatr Res 2007; 41: 57-62. (Pubitemid 44708197)
29. Li JY, Kuo TBJ, Hsieh SS, Yang CCH: Changes in electroencephalogram and heart rate during treadmill exercise in the rat. Neurosci Lett 2008; 434: 175-178.
30. Jouvet M: Neurophysiology of the states of sleep. Physiol Rev 1967; 47: 117-177.
31. Kuo TBJ, Chan SHH: Continuous, on-line, real-time spectral analysis of systemic arterial pressure signals. Am J Physiol 1993; 264:H2208-H2213. (Pubitemid 23205995)
32. Berger RD, Saul JP, Cohen RJ: Transfer function analysis of autonomic regulation. I. Canine atrial rate response. Am J Physiol 1989; 256:H142-H152.
33. Japundzic N, Grichois ML, Zitoun P, Laude D, Elghozi JL: Spectral analysis of blood pressure and heart rate in conscious rats: effects of autonomic blockers. J Auton Nerv Syst 1990; 30: 91-100. (Pubitemid 20192822)
34. Pruessner JC, Kirschbaum C, Meinlschmid G, Hellhammer DH: Two formulas for computation of the area under the curve represent measures of total hormone concentration versus time-dependent change. Psychoneuroendocrinology 2003; 28: 916-931. (Pubitemid 36936799)
35. Brown S: Excess mortality of schizophrenia: a meta-analysis. Br J Psychiatry 1997; 171: 502-508.
36. Brown S, Inskip H, Barraclough B: Causes of the excess mortality of schizophrenia. Br J Psychiatry 2000; 177: 212-217.
37. Jindal R, MacKenzie EM, Baker GB, Yeragani VK: Cardiac risk and schizophrenia. J Psychiatry Neurosci 2005; 30: 393-395.
38. Boettger S, Hoyer D, Falkenhahn K, Kaatz M, Yeragani VK, Bar KJ: Altered diurnal autonomic variation and reduced vagal information flow in acute schizophrenia. Clin Neurophysiol 2006; 117: 2715-2722. (Pubitemid 44751625)
39. Bar KJ, Wernich K, Boettger S, Cordes J, Boettger MK, Loffler S, Kornischka J, Agelink MW: Relationship between cardiovagal modulation and psychotic state in patients with paranoid schizophrenia. Psychiatry Res 2008; 157: 255-257. (Pubitemid 350166556)
40. Baldessarini RJ, Frankenburg FR: Clozapine: a novel antipsychotic agent. N Engl J Med 1991; 324: 746-754.
41. Beckers F, Verheyden B, Ramaekers D, Swynghedauw B, Aubert AE: Effects of autonomic blockade on non-linear cardiovascular variability indices in rats. Clin Exp Pharmacol Physiol 2006; 33: 431-439.
42. Kannel WB, Kannel C, Paffenbarger RS Jr, Cupples LA: Heart rate and cardiovascular mortality: the Framingham Study. Am Heart J 1987; 113: 1489-1494. (Pubitemid 17092823)
43. Gillman MW, Kannel WB, Belanger A, D'Agostino RB: Influence of heart rate on mortality among persons with hypertension: the Framingham Study. Am Heart J 1993; 125: 1148-1154. (Pubitemid 23117352)
44. Perret-Guillaume C, Joly L, Benetos A: Heart rate as a risk factor for cardiovascular disease. Prog Cardiovasc Dis 2009; 52: 6-10.
45. Malaspina D, Dalack G, Leitman D, Corcoran C, Amador XF, Yale S, Glassman A, Gorman JM: Low heart rate variability is not caused by typical neuroleptics in schizophrenia patients. CNS Spectr 2002; 7: 53-57. (Pubitemid 34773519)
46. Elman I, Goldstein DS, Green AI, Eisenhofer G, Folio CJ, Holmes CS, Pickar D, Breier A: Effects of risperidone on the peripheral noradrenegic system in patients with schizophrenia: a comparison with clozapine and placebo. Neuropsychopharmacology 2002; 27: 293-300. (Pubitemid 34686980)
47. Kuo TBJ, Chen CY, Hsu YC, Yang CCH: Performance of the frequency domain indices with respect to sleep staging. Clin Neurophysiol 2011, in press.
48. Ruch W, Asper H, Burki HR: Effect of clozapine on the metabolism of serotonin in rat brain. Acta Vitaminol Enzymol 1975; 29: 85-89.
49. Becker A, Grecksch G: Ketamine-induced changes in rat behaviour: a possible animal model of schizophrenia. Test of predictive validity. Prog Neuropsychopharmacol Biol Psychiatry 2004; 28: 1267-1277. (Pubitemid 39592924)
50. Centorrino F, Price BH, Tuttle M, Bahk WM, Hennen J, Albert MJ, Baldessarini RJ: EEG abnormalities during treatment with typical and atypical antipsychotics. Am J Psychiatry 2002; 159: 109-115. (Pubitemid 41070735)