Mass spectrometric identification and characterization of new fluoxymesterone metabolites in human urine by liquid chromatography time-of-flight tandem mass spectrometry

Steroids

Volumn 77, Issue 8-9, 2012, Pages 871-877

  Lu, Jianghai ^a   He, Genye ^a   Wang, Xiaobing ^a   Xu, Youxuan ^a   Wu, Yun ^a   Dong, Ying ^a   Liu, Xin ^a   He, Zhenwen ^a   Zhao, Jian ^a   Yuan, Hong ^a  

^a China Anti Doping Agency   (China)

Author keywords

Fluoxymesterone; Liquid chromatography time of flight tandem mass spectrometry; Metabolism

Indexed keywords

9 FLURO 17 BETA 17 METHYL 11-EN 5A ANDROSTAN 3 ONE; 9 FLURO 17 BETA 17 METHYL 5 ANDROSTAN 3,6 11 TRIONE; 9 FLURO 17 BETA17 METHYL 11 EN 5 BETA ANDROSTAN 3 ONE; FLUOXYMESTERONE; ISOTOPE; STEROID; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL COMPOSITION; CONTROLLED STUDY; DRUG FORMULATION; DRUG STRUCTURE; IONIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PROTON TRANSPORT; TANDEM MASS SPECTROMETRY; TIME OF FLIGHT MASS SPECTROMETRY; URINALYSIS;

CHROMATOGRAPHY, LIQUID; FLUOXYMESTERONE; HUMANS; MOLECULAR STRUCTURE; TANDEM MASS SPECTROMETRY;

EQUIDAE;

EID: 84861637569     PISSN: 0039128X     EISSN: 18785867     Source Type: Journal    
DOI: 10.1016/j.steroids.2012.04.003     Document Type: Article

References (27)

1. M.A. Lawson, D. Li, C.A. Glidewell-Kenney, and F.J. López Androgen responsiveness of the pituitary gonadotrope cell line LbetaT2 J Endocrinol 170 2001 601 607 (Pubitemid 32834326)
2. C. Rose, C. Kamby, H.T. Mouridsen, M. Andersson, L. Bastholt, K.A. Moller, J. Andersen, P. Munkholm, P. Dombernowsky, and I.J. Christensen Combined endocrine treatment of elderly postmenopausal patients with metastatic breast cancer. A randomized trial of tamoxifen vs. tamoxifen+ aminoglutethimide and hydrocortisone and tamoxifen+ fluoxymesterone in women above 65 years of age Breast Cancer Res Treat 61 2000 103 110
3. G.W. Sledge Jr, P. Hu, G. Falkson, D. Tormey, and M. Abeloff Comparison of chemotherapy with chemohormonal therapy as first-line therapy for metastatic, hormone-sensitive breast cancer: an Eastern Cooperative Oncology Group study J Clin Oncol 18 2000 262 266 (Pubitemid 30056413)
4. J.N. Ingle, V.J. Suman, J.A. Mailliard, J.W. Kugler, J.E. Krook, J.C. Michalak, T.M. Pisansky, L.E. Wold, J.H. Donohue, M.P. Goetz, and E.A. Perez Randomized trial of tamoxifen alone or combined with fluoxymesterone as adjuvant therapy in postmenopausal women with resected estrogen receptor positive breast cancer. North Central Cancer Treatment Group Trial 89-30-52 Breast Cancer Res Treat 98 2006 217 222 (Pubitemid 44050772)
5. X.S. Deng, A. Kurosu, and D.J. Pounder Detection of anabolic steroids in head hair J Forensic Sci 44 1999 343 346 (Pubitemid 29131844)
6. J.M. Kirk, J. Tarbin, and B.J. Keely Analysis of androgenic steroid girard P hydrazones using multistage tandem mass spectrometry Rapid Commun Mass Spectrom 20 2006 1247 1252
7. M. Yamada, S. Aramaki, M. Kurosawa, I. Kijima-Suda, K. Saito, and H. Nakazawa Simultaneous doping analysis of main urinary metabolites of anabolic steroids in horse by ion-trap gas chromatography-tandem mass spectrometry Anal Sci 24 9 2008 1199 1204
8. E.M. Malone, C.T. Elliott, D.G. Kennedy, and L. Regan Development of a rapid method for the analysis of synthetic growth promoters in bovine muscle using liquid chromatography tandem mass spectrometry Anal Chim Acta 637 2009 112 120
9. R. Muñiz-Valencia, R. Gonzalo-Lumbreras, A. Santos-Montes, and R. Izquierdo-Hornillos Liquid chromatographic method development for anabolic androgenic steroids using a monolithic column. Application to animal feed samples Anal Chim Acta 611 2008 103 112
10. L.K. Amundsen, J.T. Kokkonen, S. Rovio, and H. Sirén Analysis of anabolic steroids by partial filling micellar electrokinetic capillary chromatography and electrospray mass spectrometry J Chromatogr A 1040 2004 123 131 (Pubitemid 38638482)
11. A. Leinonen, T. Kuuranne, T. Kotiaho, and R. Kostiainen Screening of free 17-alkyl-substituted anabolic steroids in human urine by liquid chromatography-electrospray ionization tandem mass spectrometry Steroids 69 2004 101 109 (Pubitemid 38315083)
12. O.J. Pozo, K. Deventer, P.V. Eenoo, and F.T. Delbeke Efficient approach for the comprehensive detection of unknown anabolic steroids and metabolites in human urine by liquid chromatography-electrospray-tandem mass spectrometry Anal Chem 80 2008 1709 1720 (Pubitemid 351429577)
13. E. Sangiorgi, M. Curatolo, W. Assini, and E. Bozzoni Application of neutral loss mode in liquid chromatography-mass spectrometry for the determination of corticosteroids in bovine urine Anal Chim Acta 483 2003 259 267 (Pubitemid 36507191)
14. M. Yamada, S. Aramaki, T. Hosoe, M. Kurosawa, I. Kijima-Suda, K. Saito, and H. Nakazawa Characterization and quantification of fluoxymesterone metabolite in horse urine by gas chromatography mass spectrometry Anal Sci 24 2008 911 914
15. S.M. Stanley, S. Kent, and J.P. Rodgers Biotransformation of 17-alkyl steroids in the equine: high-performance liquid chromatography-mass spectrometric and gas chromatography-mass spectrometric analysis of fluoxymesteronemetabolites in urine samples J Chromatogr B Biomed Sci Appl 704 1997 119 128 (Pubitemid 28021896)
16. P. Van Eenoo, and F.T. Delbeke J. Metabolism and excretion of anabolic steroids in doping control - New steroids and new insights J Steroid Biochem Mol Biol 101 2006 161 178 (Pubitemid 44573810)
17. A.G. Fragkaki, Y.S. Angelis, A. Tsantili-Kakoulidou, M. Koupparis, and C. Georgakopoulos Schemes of metabolic patterns of anabolic androgenic steroids for the estimation of metabolites of designer steroids in human urine J Steroid Biochem Mol Biol 115 2009 44 61
18. O.J. Pozo, W. Van Thuyne, K. Deventer, P. Van Eenoo, and F.T. Delbeke Elucidation of urinary metabolites of fluoxymesterone by liquid chromatography-tandem mass spectrometry and gas chromatography-mass spectrometry J Mass Spectrom 43 3 2008 394 408 (Pubitemid 351373939)
19. O.J. Pozo, P. Van Eenoo, and F.T. Delbeke Ionization of anabolic steroids by adduct formation in liquid chromatography electrospray mass spectrometry J Mass Spectrom 42 2007 497 516 (Pubitemid 46649086)
20. M. Thevis, and W. Schanzer Current literature in mass spectrometry Mass Spectrom Rev 26 2007 79 107
21. O.J. Pozo, P. Van Eenoo, S. Grimalt, V. Sancho, F. Herandez, and F.T. Delbeke Collision-induced dissociation of 3-keto anabolic steroids and related compounds after electrospray ionization. Consideration for structural elucidation Rapid Commun Mass Spectrom 22 2008 4009 4024
22. M. Thevis, A.A. Makarov, S. Horning, and W. Schanzer Mass spectrometry of stanozolol and its analogues using electrospray ionization and collision-induced dissociation with quadrupole-linear ion trap and linear ion trap-orbitrap hybrid mass analyzers Rapid Commun Mass Spectrom 19 2005 3369 3378 (Pubitemid 41682068)
23. M. Thevis, and W. Schanzer Mass spectrometric analysis of androstan-17beta-ol-3-one and androstadiene-17beta-ol-3-one isomers J Am Soc Mass Spectrom 16 2005 1660 1669 (Pubitemid 41345158)
24. M. Thevis, U. Bommerich, G. Opfermann, and W. Schanzer Characterization of chemically modified steroids for doping control purposes by electrospray ionization tandem mass spectrometry J Mass Spectrom 40 2005 494 502 (Pubitemid 40637873)
25. F. Guan, L.R. Soma, Y. Luo, C.E. Uboh, and S. Peterman Collision-induced dissociation pathways of anabolic steroids by electrospray ionization tandem mass spectrometry J Am Soc Mass Spectrom 17 2006 477 490
26. F.L. Jean, T. Erin, T. Laird, B. Carl, and C. Nathalie Detecting doping Anal Chem 77 2005 3164 3172
27. Y. Kim, Y. Lee, M. Kim, Y.H. Kim, and W. Lee Determination and excretion study of gestrinone in human urine by high performance liquid chromatography and gas chromatography/mass spectrometry Rapid Commun Mass Spectrom 14 2000 1293 1300 (Pubitemid 30489506)