Pore networks and polymer rearrangement on a drug-eluting stent as revealed by correlated confocal Raman and atomic force microscopy

Langmuir

Volumn 28, Issue 21, 2012, Pages 8238-8243

  Biggs, Kevin B ^a   Balss, Karin M ^a   Maryanoff, Cynthia A ^a  

^a JOHNSON AND JOHNSON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AFM; CARRIER MATRIX; CHEMICAL SURFACES; COATING MORPHOLOGY; CONFOCAL RAMAN; CORONARY STENTS; DRUG RELEASE; DRUG-ELUTING STENTS; IN-VITRO; MEDICAL DEVICES; MULTICOMPONENTS; POLY (ETHYLENE-CO-VINYL ACETATE); POLY(N-BUTYL METHACRYLATE) (PN-BMA); PORE FORMATION; PORE NETWORKS; PORE THROAT; REGION OF INTEREST;

ARTIFICIAL ORGANS; ATOMIC FORCE MICROSCOPY; MORPHOLOGY; STENTS;

PLASTIC COATINGS;

ETHYLENEVINYLACETATE COPOLYMER; METHACRYLIC ACID DERIVATIVE; POLYBUTYLMETHACRYLATE; POLYVINYL DERIVATIVE;

ARTICLE; ATOMIC FORCE MICROSCOPY; CHEMISTRY; DRUG ELUTING STENT; RAMAN SPECTROMETRY;

DRUG-ELUTING STENTS; METHACRYLATES; MICROSCOPY, ATOMIC FORCE; POLYVINYLS; SPECTRUM ANALYSIS, RAMAN;

EID: 84861621899     PISSN: 07437463     EISSN: 15205827     Source Type: Journal    
DOI: 10.1021/la300808z     Document Type: Article

References (21)

1. http://www.heart.org/HEARTORG/ http://www.heart.org/HEARTORG/.
2. Sousa, J. E.; Costa, M. A.; Abizaid, A.; Abizaid, A. S.; Feres, F.; Pinto, I. M. F.; Seixas, A. C.; Staico, R.; Mattos, L. A.; Sousa, A. G. M. R.; Falotico, R.; Jaeger, J.; Popma, J. J.; Serruys, P. W. Lack of neointimal proliferation after implantation of sirolimus-coated stents in human coronary arteries. A quantitative coronary angiography and three-dimensional intravascular ultrasound study Circulation 2001, 103, 192-195
3. Suzuki, T.; Kopia, G.; Hayashi, S.-I.; Bailey, L. R.; Llanos, G.; Wilensky, R.; Klugherz, B. D.; Papandreou, G.; Narayan, P.; Leon, M. B.; Yeung, A. C.; Tio, F.; Tsao, P. S.; Falotico, R.; Carter, A. J. Stent-based delivery of sirolimus reduces neointimal formation in a porcine coronary model Circulation 2001, 104, 1188-1193
4. Spaulding, C. Safety and efficacy update on first-generation drug-eluting stents Am. J. Cardiol. 2008, 102, 18J-23J
5. Kaiser, C.; Galatius, S.; Erne, P.; Eberli, F.; Alber, H.; Rickli, H.; Pedrazzini, G.; Hornig, B.; Bertel, O.; Bonetti, P.; De Servi, S.; Brunner-La Rocca, H.-P.; Ricard, I.; Pfisterer, M. Drug-eluting versus bare-metal stents in large coronary arteries N. Engl. J. Med. 2010, 363, 2310-2319
6. Varenne, O.; Spaulding, C. Comparison of available drug eluting stents Sang Thromb. Vaiss. 2007, 19, 17-24
7. Balss, K. M.; Llanos, G.; Papandreou, G.; Maryanoff, C. A. Quantitative spatial distribution of sirolimus and polymers in drug-eluting stents using confocal Raman microscopy J. Biomed. Mater. Res., Part A 2008, 85, 258-270
8. Balss, K. M.; Long, F. H.; Veselov, V.; Orana, A.; Akerman-Revis, E.; Papandreou, G.; Maryanoff, C. A. Multivariate analysis applied to the study of spatial distributions found in drug-eluting stent coatings by confocal Raman microscopy Anal. Chem. 2008, 80, 4853-4859
9. Fisher, G. L.; Belu, A. M.; Mahoney, C. M.; Wormuth, K.; Sanada, N. Three-dimensional time-of-flight secondary ion mass spectrometry imaging of a pharmaceutical in a coronary stent coating as a function of elution time Anal. Chem. 2009, 81, 9930-9940
10. Hsu, S. L. Raman spectroscopic analysis of drug delivery systems Am. Pharm. Rev. 2006, 9, 58-64
11. Puskas, J. E.; Munoz-Robledo, L. G.; Hoerr, R. A.; Foley, J.; Schmidt, S. P.; Evancho-Chapman, M.; Dong, J. P.; Frethem, C.; Haugstad, G. Drug-eluting stent coatings Wiley Interdiscip. Rev.: Nanomed. Nanobiotechnol. 2009, 1, 451-462
12. Dong, J.; Foley, J. D.; Frethem, C. D.; Hoerr, R. A.; Matuszewski, M. J.; Puskas, J. E.; Haugstad, G. Multimodal dynamic imaging of therapeutic biomedical coatings in aqueous medium Langmuir 2009, 25, 5442-5445
13. Mahoney, C. M.; Fahey, A. J. Three-dimensional compositional analysis of drug eluting stent coatings using cluster secondary ion mass spectrometry Anal. Chem. 2008, 80, 624-632
14. Mahoney, C. M.; Fahey, A. J.; Gillen, G. Temperature-controlled depth profiling of poly(methyl methacrylate) using cluster secondary ion mass spectrometry. 1. Investigation of depth profile characteristics Anal. Chem. 2007, 79, 828-836
15. Mahoney, C. M.; Patwardhan, D. V.; McDermott, M. K. Characterization of drug-eluting stent (DES) materials with cluster secondary ion mass spectrometry (SIMS) Appl. Surf. Sci. 2006, 252, 6554-6557
16. Braun, R. M.; Cheng, J.; Parsonage, E. E.; Moeller, J.; Winograd, N. Surface and depth profiling investigation of a drug-loaded copolymer utilized to coat Taxus Express2 stents Anal. Chem. 2006, 78, 8347-8353
17. Ranade, S. V.; Miller, K. M.; Richard, R. E.; Chan, A. K.; Allen, M. J.; Helmus, M. N. Physical characterization of controlled release of paclitaxel from the TAXUS Express2 drug-eluting stent J. Biomed. Mater. Res., Part A 2004, 71, 625-634
18. Barocas, V.; Drasler, W.; Girton, T.; Guler, I.; Knapp, D.; Moeller, J.; Parsonage, E. A Dissolution-diffusion model for the TAXUS (TM) drug-eluting stent with surface burst estimated from continuum percolation J. Biomed. Mater. Res., Part B 2009, 90, 267-274
19. Chen, M.-C.; Liang, H.-F.; Chiu, Y.-L.; Chang, Y.; Wei, H.-J.; Sung, H.-W. A novel drug-eluting stent spray-coated with multi-layers of collagen and sirolimus J. Controlled Release 2005, 108, 178-189
20. Wiemer, M.; Butz, T.; Schmidt, W.; Schmitz, K.-P.; Horstkotte, D.; Langer, C. Scanning electron microscopic analysis of different drug eluting stents after failed implantation: from nearly undamaged to major damaged polymers Catheter Cardiovasc. Interv. 2010, 75, 905-911
21. Basalus Mounir, W. Z.; Ankone Marc, J. K.; van Houwelingen Gert, K.; de Man Frits, H. A. F.; von Birgelen, C. Coating irregularities of durable polymer-based drug-eluting stents as assessed by scanning electron microscopy EuroIntervention 2009, 5, 157-165