Novel thermo- and pH-responsive hydroxypropyl cellulose- and poly (l-glutamic acid)-based microgels for oral insulin controlled release

Carbohydrate Polymers

Volumn 89, Issue 4, 2012, Pages 1207-1214

  Bai, Yunyan ^a   Zhang, Zhe ^a   Zhang, Aiping ^a   Chen, Li ^a   He, Chaoliang ^b   Zhuang, Xiuli ^b   Chen, Xuesi ^b  

^a NORTHEAST NORMAL UNIVERSITY   (China)

^b CHANGCHUN INSTITUTE OF APPLIED CHEMISTRY   (China)

Author keywords

Controlled release; Insulin; Microgel; pH responsive; Thermo responsive

Indexed keywords

CONTROLLED RELEASE; DYNAMIC LIGHT SCATTERING MEASUREMENT; GASTRIC JUICE; HYDRODYNAMIC RADIUS; HYDROXYPROPYL CELLULOSE; IN-VITRO; INTESTINAL FLUID; MICRO-GELS; MICROGEL; MICROGEL PARTICLES; ORAL DRUG DELIVERY SYSTEM; PH VALUE; PH-RESPONSIVE; POLY (LGLUTAMIC ACID); THERMO-RESPONSIVE;

AMINO ACIDS; CARBOXYLIC ACIDS; CELLULOSE; DRUG DELIVERY; EMULSION POLYMERIZATION; HYDRODYNAMICS; INSULIN;

GELS;

ANTIDIABETIC AGENT; CELLULOSE; DELAYED RELEASE FORMULATION; HYDROXYPROPYLCELLULOSE; INSULIN; POLYGLUTAMIC ACID;

ANALOGS AND DERIVATIVES; CHEMISTRY; DELAYED RELEASE FORMULATION; HEAT; HUMAN; ORAL DRUG ADMINISTRATION; PH; PHARMACOKINETICS;

ADMINISTRATION, ORAL; CELLULOSE; DELAYED-ACTION PREPARATIONS; HOT TEMPERATURE; HUMANS; HYDROGEN-ION CONCENTRATION; HYPOGLYCEMIC AGENTS; INSULIN; POLYGLUTAMIC ACID;

EID: 84861621410     PISSN: 01448617     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.carbpol.2012.03.095     Document Type: Article

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