Effect of L-arginine supplement on liver regeneration after partial hepatectomy in rats

World Journal of Surgical Oncology

Volumn 10, Issue , 2012, Pages

  Kurokawa, Tsuyoshi ^a,e   An, Jun ^a,b   Tsunekawa, Koji ^a,c   Shimomura, Yoshiharu ^d   Kazama, Shunsuke ^d   Ishikawa, Naohisa ^a   Nonami, Toshiaki ^a   Sugiyama, Satoru ^c  

^a AICHI MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b Dalian Municipal Friendship Hospital   (China)

^c Institute of Applied Biochemistry   (Japan)

^d NAGOYA UNIVERSITY   (Japan)

^e Masuko Memorial Hospital   (Japan)

Author keywords

Amino acid; Hepatectomy; L arginine; L glutamine; Liver regeneration

Indexed keywords

ALANINE; ARGININE; CYCLINE; DNA; GLUTAMINE; RNA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA CONTENT; DRUG EFFECT; IMMUNOHISTOCHEMISTRY; LIVER PARENCHYMA; LIVER REGENERATION; LIVER WEIGHT; MALE; NONHUMAN; PARTIAL HEPATECTOMY; RAT; RNA ANALYSIS;

ADMINISTRATION, ORAL; ALANINE; ANIMALS; ARGININE; DNA; GLUTAMINE; HEPATECTOMY; IMMUNOENZYME TECHNIQUES; LIVER DISEASES; LIVER REGENERATION; MALE; POLYMERASE CHAIN REACTION; PROLIFERATING CELL NUCLEAR ANTIGEN; RATS; RATS, WISTAR; RNA;

EID: 84861602537     PISSN: None     EISSN: 14777819     Source Type: Journal    
DOI: 10.1186/1477-7819-10-99     Document Type: Article

References (23)

1. Cacanyiova S, Kristek F, Malekova M, Ondrias K. Effects of chronic neuronal nitric oxide-synthase inhibition on arterial function and structure in spontaneously hypertensive rats. J Physiol Pharmacol 2012, 63(1):12-28.
2. Chen J, Jin J, Song M, Dong H, Zhao G, Huang L. C-reactive protein down-regulates endothelial nitric oxide synthase expression and promotes apoptosis in endothelial progenitor cells through receptor for advanced glycation end-products. Gene 2012, 496(2):128-135. 10.1016/j.gene.2011.12.039, 22301267.
3. Yao J, Zhu Y, Sun W, Sawada N, Hiramatsu N, Takeda M, Kitamura M. Irsogladine maleate potentiates the effects of nitric oxide on activation of cAMP signaling pathways and suppression of mesangial cell mitogenesis. Br J Pharmacol 2007, 151(4):457-466. 2013962, 17435794.
4. Mei Y, Thevananther S. Endothelial nitric oxide synthase is a key mediator of hepatocyte proliferation in response to partial hepatectomy in mice. Hepatology 2011, 54:1777-1789. 10.1002/hep.24560, 21748771.
5. Cantre D, Schuett H, Hildebrandt A, Dold S, Menger MD, Vollmar B, Eipel C. Nitric oxide reduces organ injury and enhances regeneration of reduced-size livers by increasing hepatic arterial flow. Br J Surg 2008, 95:785-792. 10.1002/bjs.6139, 18412296.
6. Lawson CM, Miller KR, Smith VL, McClave SA. Appropriate protein and specific amino acid delivery can improve patient outcome: fact or fantasy?. Curr Gastroenterol Rep 2011, 13(4):380-387. 10.1007/s11894-011-0201-0, 21607651.
7. Higgins GM, Anderson RM. Experimental pathology of the liver. Restoration of the liver of the white rat following partial surgical removal. Arch Pathol 1931, 12:186-206.
8. Assy N, Hussein O, Khalil A, Luder A, Szvalb S, Paizi M, Spira G. The beneficial effect of aspirin and enoxaparin on fibrosis progression and regenerative activity in a rat model of cirrhosis. Dig Dis Sci 2007, 52(5):1187-1193. 10.1007/s10620-006-9595-1, 17372820.
9. Mok E, Hankard R. Glutamine supplementation in sick children: Is it beneficial?. J Nutr Metab 2011, 14.
10. Fillmann H, Kretzmann NA, San-Miguel B, Llesuy S, Marroni N, González-Gallego J. Glutamine inhibits over-expression of pro-inflammatory genes and down-regulates the nuclear factor kappaB pathway in an experimental model of colitis in the rat. Toxicology 2007, 236(3):217-226. 10.1016/j.tox.2007.04.012, 17543437.
11. Yoshida S, Yunoki T, Aoyagi K, Ohta J, Ishibashi N, Noake T, Kakegawa T. Effect of glutamine supplement and hepatectomy on DNA and protein synthesis in the remnant liver. J Sur Res 1995, 59:475-481.
12. Passos De Jesus Mazza R, Bertevello PL, Matos De Miranda Torrinhas R, Nonogaki S, Alves VAF, Rodrigues JG, Waitzberg DL. Effect of glutamine dipeptide on hepatic regeneration in partially hepatectomized malnourished rats. Nutrition 2003, 19:930-935. 10.1016/S0899-9007(03)00177-1, 14624941.
13. Ito A, Higashiguchi T. Effects of glutamine administration on liver regeneration following hepatectomy. Nutrition 1999, 15:23-28. 10.1016/S0899-9007(98)00133-6, 9918058.
14. Yoshida D, Akahoshi T, Kawanaka H, Yamaguchi S, Kinjyo N, Taketomi A, Tomikawa M, Shirabe K, Maehara Y, Hashizume M. Roles of vascular endothelial growth factor and endothelial nitric oxide synthase during revascularization and regeneration after partial hepatectomy in a rat model. Surg Today 2011, 41:1622-1629. 10.1007/s00595-010-4484-9, 21969195.
15. Carnovale CE, Scapini C, Alvarez ML, Favre C, Monti J, Carrillo MC. Nitric oxide release and enhancement of lipid peroxidation in regenerating liver. J Hepatol 2000, 32:798-804. 10.1016/S0168-8278(00)80249-4, 10845667.
16. Pollock, Webb W, Callaway D, O'Brien W, Howdieshell TR. Nitric oxide synthase isoform expression in a porcine model of granulation tissue formation. Surgery 2001, 129(3):341-350. 10.1067/msy.2001.111700, 11231463.
17. Inukai N, Uchida M, Miyazaki Y, Suzuki T, Yoshikawa H, Tanaka K, Morita H, Takizawa T. Nitric oxide production and its contribution to hepatocyte proliferation in normal juvenile rats. J Vet Med Sci 2010, 72(7):861-867. 10.1292/jvms.09-0551, 20179381.
18. Han G, Nguyen LN, Macheria C, Chi Y, Friedman JM, Nosanchuk JD, Martinez LR. Nitric oxide-releasing nanoparticles accelerate wound healing by promoting fbroblast migration and collagen deposision. Am J Pathol 2012, 180(4):1465-1473. 10.1016/j.ajpath.2011.12.013, 22306734.
19. Debats IBJG, Wolfs TGAM, Gotoh T, Cleutjens JPM, Peutz-Koostra CJ, van der Hulst RRWJ. Role of arginine in superficial wound healing in man. Nitric Oxide 2009, 108(2):331-336.
20. Ronco MT, Alvarez Mde L, Monti JA, Carrillo MC, Pisani GB, Lugano MC, Carnovale C, Ronco MT, Alvarez Mde L, Monti JA, Carrillo MC, Pisani GB, Lugano MC, Carnovale CE. Role of nitric oxide increase on induced programmed cell death during early stages of rat regeneration. Biochim Biophys Acta 2004, 1690:70-76. 10.1016/j.bbadis.2004.05.004, 15337172.
21. Nall JL, Wu G, Kim KH, Choi CW, Smith SB. Dietary supplementation of L-arginine and conjugated linoleic acid reduces retroperitoneal fat mass and increases lean body mass in rats. J Nutr 2009, 139(7):1279-1285. 10.3945/jn.108.102301, 19439462.
22. Qui JG, Delany HM, The EL, Gliedman ML, Chang CJ, Levenson SM. Lethality of standard total parenteral nutrition following major liver regeneration in rats is prevented by high arginine and high branched chain amino acids but not by glutamine. J Assoc Acad Minor Phys 2001, 12:109-118.
23. Witte MB, Barbul A. Arginine physiology and its implication for wound healing. Wound Rep Reg 2003, 11:419-423.