Pediatric melanomas and the atypical spitzoid melanocytic neoplasms

American Journal of Surgery

Volumn 203, Issue 6, 2012, Pages 761-767

  Hill, Sarah J ^a   Delman, Keith A ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Atypical melanocytic neoplasms; Melanoma; Sentinel lymph node biopsy; Spitz nevi; Spitz tumor

Indexed keywords

B RAF KINASE; INTERFERON; KI 67 ANTIGEN;

ATYPICAL SPITZOID MELANOCYTIC NEOPLASM; CANCER ADJUVANT THERAPY; CANCER MORTALITY; CHILDHOOD CANCER; CHROMOSOME 10; CHROMOSOME 11P; CHROMOSOME 6; CHROMOSOME 7; CHROMOSOME 9; CHROMOSOME ABERRATION; COHORT ANALYSIS; COMPARATIVE GENOMIC HYBRIDIZATION; DISEASE CLASSIFICATION; DRUG MEGADOSE; FAMILY HISTORY; GENE MUTATION; HAIR COLOR; HISTOLOGY; HISTOPATHOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; JUVENILE MELANOMA; LYMPH NODE DISSECTION; LYMPHADENECTOMY; MELANOCYTE; MELANOCYTIC NEVUS; MELANOMA; METASTASIS; ONCOGENE H RAS; ONCOGENE N RAS; OVERALL SURVIVAL; PRIORITY JOURNAL; REVIEW; SENSITIVITY AND SPECIFICITY; SENTINEL LYMPH NODE BIOPSY; SEX DIFFERENCE; SKIN CANCER; SUNBURN; SYSTEMIC THERAPY; TUMOR LOCALIZATION; ULTRASOUND;

CHILD; HUMANS; MELANOMA; NEVUS, EPITHELIOID AND SPINDLE CELL; NEVUS, PIGMENTED; SKIN NEOPLASMS; UNITED STATES;

EID: 84861593469     PISSN: 00029610     EISSN: 18791883     Source Type: Journal    
DOI: 10.1016/j.amjsurg.2011.04.008     Document Type: Review

References (71)

1. P.A. Herreid, P.E. Shapiro Age distribution of Spitz nevus vs malignant melanoma Arch Dermatol 132 1996 352 353
2. C. Requena, L. Requena, H. Kutzner Spitz nevus: a clinicopathological study of 349 cases Am J Dermatopathol 31 2009 107 116
3. C. Paniago-Pereira, J.C. Maize, A.B. Ackerman Nevus of large spindle and/or epithelioid cells (Spitz's nevus) Arch Dermatol 114 1978 1811 1823
4. D. Weedon, J.H. Little Spindle and epithelioid cell nevi in children and adults A review of 211 cases of the Spitz nevus Cancer 40 1977 217 225
5. M.W. Ludgate, D.R. Fullen, J. Lee The atypical Spitz' tumor of uncertain biologic potential: a series of 67 patients from a single institution Cancer 115 2009 631 641
6. E.M. Carr, E. Heilman, N.S. Prose Spitz nevi in black children J Am Acad Dermatol 23 1990 842 845
7. A.C. Berlingeri-Ramos, A. Morales-Burgos, J.L. Sánchez Spitz nevus in a Hispanic population: a clinicopathological study of 130 cases Am J Dermatopathol 32 2010 267 275
8. S. Spitz Melanomas of childhood Am J Pathol 24 1948 591 609
9. R.L. Barnhill, L. Cerroni, M. Cook State of the art, nomenclature, and points of consensus and controversy concerning benign melanocytic lesions: outcome of an international workshop Adv Anat Pathol 17 2010 73 90
10. A. Spatz, E. Calonje, S. Handfield-Jones Spitz tumors in children: a grading system for risk stratification Arch Dermatol 135 1999 282 285
11. K.J. Smith, T.L. Barrett, H.G. Skelton Spindle cell and epithelioid cell nevi with atypia and metastasis (malignant Spitz nevus) Am J Surg Pathol 13 1989 931 939
12. K.J. Busam, R.L. Barnhill Pagetoid Spitz nevus Intraepidermal Spitz' tumor with prominent pagetoid spread Am J Surg Pathol 19 1995 1061 1067
13. H. Kamino, T.J. Flotte, E. Misheloff Eosinophilic globules in Spitz's nevi New findings and a diagnostic sign Am J Dermatopathol 1 1979 319 324
14. N. Walsh, K. Crotty, A. Palmer Spitz nevus versus spitzoid malignant melanoma: an evaluation of the current distinguishing histopathologic criteria Hum Pathol 29 1998 1105 1112
15. K.A. Crotty, R.A. Scolyer, L. Li Spitz' naevus versus Spitzoid melanoma: when and how can they be distinguished? Pathology 34 2002 6 12
16. L.X. Li, K.A. Crotty, R.A. Scolyer Use of multiple cytometric markers improves discrimination between benign and malignant melanocytic lesions: a study of DNA microdensitometry, karyometry, argyrophilic staining of nucleolar organizer regions and MIB1-Ki67 immunoreactivity Melanoma Res 13 2003 581 586
17. L.X. Li, K.A. Crotty, S.W. McCarthy A zonal comparison of MIB1-Ki67 immunoreactivity in benign and malignant melanocytic lesions Am J Dermatopathol 22 2000 489 495
18. E. Rieger, R. Hofmann-Wellenhof, H.P. Soyer Comparison of proliferative activity as assessed by proliferating cell nuclear antigen (PCNA) and Ki-67 monoclonal antibodies in melanocytic skin lesions A quantitative immunohistochemical study J Cutan Pathol 20 1993 229 236
19. S. Moretti, A. Spallanzani, A. Chiarugi Correlation of Ki-67 expression in cutaneous primary melanoma with prognosis in a prospective study: different correlation according to thickness J Am Acad Dermatol 44 2001 188 192
20. R.T. Vollmer Use of Bayes rule and MIB-1 proliferation index to discriminate Spitz nevus from malignant melanoma Am J Clin Pathol 122 2004 499 505
21. P.D. Da Forno, J.H. Pringle, A. Fletcher BRAF, NRAS and HRAS mutations in spitzoid tumours and their possible pathogenetic significance Br J Dermatol 161 2009 364 372
22. P.D. Da Forno, A. Fletcher, J.H. Pringle Understanding spitzoid tumours: new insights from molecular pathology Br J Dermatol 158 2008 4 14
23. A. Demunter, M. Stas, H. Degreef Analysis of N- and K-ras mutations in the distinctive tumor progression phases of melanoma J Invest Dermatol 117 2001 1483 1489
24. M.C. van Dijk, M.R. Bernsen, D.J. Ruiter Analysis of mutations in B-ref, N-RAS, and H-RAS genes in the differential diagnosis of Spitz nevus and spitzoid melanoma Am J Surg Pathol 29 2005 1145 1151
25. H. Davies, G.R. Bignell, C. Cox Mutations of the BRAF gene in human cancer Nature 417 2002 949 954
26. G. Saldanha, D. Purnell, A. Fletcher High BRAF mutation frequency does not characterize all melanocytic tumor types Int J Cancer 111 2004 705 710
27. A.S. Yazdi, G. Palmedo, M.J. Flaig Mutations of the BRAF gene in benign and malignant melanocytic lesions J Invest Dermatol 121 2003 1160 1162
28. D.R. Fullen, J.N. Poynter, L. Lowe BRAF and NRAS mutations in spitzoid melanocytic lesions Mod Pathol 19 2006 1324 1332
29. M. Gill, J. Cohen, N. Renwick Genetic similarities between Spitz nevus and Spitzoid melanoma in children Cancer 101 2004 2636 2640
30. G. Palmedo, M. Hantschke, A. Rütten The T1796A mutation of the BRAF gene is absent in Spitz nevi J Cutan Pathol 31 2004 266 270
31. J.O. Indsto, S. Kumar, L. Wang Low prevalence of RAS-RAF-activating mutations in Spitz melanocytic nevi compared with other melanocytic lesions J Cutan Pathol 34 2007 448 455
32. W.A. Blokx, M.C. van Dijk, D.J. Ruiter Molecular cytogenetics of cutaneous melanocytic lesions - diagnostic, prognostic and therapeutic aspects Histopathology 56 2010 121 132
33. B.C. Bastian, U. Wesselmann, D. Pinkel Molecular cytogenetic analysis of Spitz nevi shows clear differences to melanoma J Invest Dermatol 113 1999 1065 1069
34. J.D. Harvell, S. Kohler, S. Zhu High-resolution array-based comparative genomic hybridization for distinguishing paraffin-embedded Spitz nevi and melanomas Diagn Mol Pathol 13 2004 22 25
35. B.C. Bastian Molecular genetics of melanocytic neoplasia: practical applications for diagnosis Pathology 36 2004 458 461
36. J.D. Harvell, B.C. Bastian, P.E. LeBoit Persistent (recurrent) Spitz nevi: a histopathologic, immunohistochemical, and molecular pathologic study of 22 cases Am J Surg Pathol 26 2002 654 661
37. B. Ghazi, G.W. Carlson, D.R. Murray Utility of lymph node assessment for atypical spitzoid melanocytic neoplasms Ann Surg Oncol 17 2010 2471 2475
38. R.L. Barnhill, Z.B. Argenyi, L. From Atypical Spitz nevi/tumors: lack of consensus for diagnosis, discrimination from melanoma, and prediction of outcome Hum Pathol 30 1999 513 520
39. L.D. Su, D.R. Fullen, V.K. Sondak Sentinel lymph node biopsy for patients with problematic spitzoid melanocytic lesions: a report on 18 patients Cancer 97 2003 499 507
40. C. Urso, L. Borgognoni, C. Saieva Sentinel lymph node biopsy in patients with "atypical Spitz tumors." A report on 12 cases Hum Pathol 37 2006 816 823
41. R. Murali, R.N. Sharma, J.F. Thompson Sentinel lymph node biopsy in histologically ambiguous melanocytic tumors with spitzoid features (so-called atypical spitzoid tumors) Ann Surg Oncol 15 2008 302 309
42. T.C. Gamblin, H. Edington, J.M. Kirkwood Sentinel lymph node biopsy for atypical melanocytic lesions with spitzoid features Ann Surg Oncol 13 2006 1664 1670
43. Y. Gurbuz, R. Apaydin, B. Muezzinolu A current dilemma in histopathology: atypical Spitz' tumor or Spitzoid melanoma? Pediatr Dermatol 19 2002 99 102
44. J.B. Roaten, D.A. Partrick, N. Pearlman Sentinel lymph node biopsy for melanoma and other melanocytic tumors in adolescents J Pediatr Surg 40 2005 232 235
45. K.J. Busam, R. Murali, M. Pulitzer Atypical spitzoid melanocytic tumors with positive sentinel lymph nodes in children and teenagers, and comparison with histologically unambiguous and lethal melanomas Am J Surg Pathol 33 2009 1386 1395
46. R.V. Mandal, R. Murali, K.F. Lundquist Pigmented epithelioid melanocytoma: favorable outcome after 5-year follow-up Am J Surg Pathol 33 2009 1778 1782
47. C. Lim, R. Murali, S.W. McCarthy Pigmented epithelioid melanocytoma: a recently described melanocytic tumour of low malignant potential Pathology 42 2010 284 286
48. M.E. Murphy, J.D. Boyer, M.E. Stashower The surgical management of Spitz nevi Dermatol Surg 28 2002 1065 1069
49. J.M. Thomas, J. Newton-Bishop, R. A'Hern Excision margins in high-risk malignant melanoma N Engl J Med 350 2004 757 766
50. S.N. Gelbard, J.M. Tripp, A.A. Marghoob Management of Spitz nevi: a survey of dermatologists in the United States J Am Acad Dermatol 47 2002 224 230
51. S.W. Kelley, C.J. Cockerell Sentinel lymph node biopsy as an adjunct to management of histologically difficult to diagnose melanocytic lesions: a proposal J Am Acad Dermatol 42 2000 527 530
52. C.D. Downard, L.B. Rapkin, K.W. Gow Melanoma in children and adolescents Surg Oncol 16 2007 215 220
53. A.S. Pappo Melanoma in children and adolescents Eur J Cancer 39 2003 2651 2661
54. J.J. Strouse, T.R. Fears, M.A. Tucker Pediatric melanoma: risk factor and survival analysis of the surveillance, epidemiology and end results database J Clin Oncol 23 2005 4735 4741
55. A.M. Linabery, J.A. Ross Trends in childhood cancer incidence in the U.S. (1992-2004) Cancer 112 2008 416 432
56. J.R. Lange, B.E. Palis, D.C. Chang Melanoma in children and teenagers: an analysis of patients from the National Cancer DataBase J Clin Oncol 25 2007 1363 1368
57. S.N. Markovic, L.A. Erickson, R.D. Rao Malignant melanoma in the 21st century, part 1: Epidemiology, risk factors, screening, prevention, and diagnosis Mayo Clin Proc 82 2007 364 380
58. C. Fishman, M.C. Mihm Jr, A.J. Sober Diagnosis and management of nevi and cutaneous melanoma in infants and children Clin Dermatol 20 2002 44 50
59. D.J. Trozak, W.D. Rowland, F. Hu Metastatic malignant melanoma in prepubertal children Pediatrics 55 1975 191 204
60. D.P. Livestro, E.M. Kaine, J.S. Michaelson Melanoma in the young: differences and similarities with adult melanoma: a case-matched controlled analysis Cancer 110 2007 614 624
61. D.R. Berk, E. LaBuz, S.S. Dadras Melanoma and melanocytic tumors of uncertain malignant potential in children, adolescents and young adults - the Stanford experience 1995-2008 Pediatr Dermatol 27 2010 244 254
62. A. Ferrari, A. Bono, M. Baldi Does melanoma behave differently in younger children than in adults? A retrospective study of 33 cases of childhood melanoma from a single institution Pediatrics 115 2005 649 654
63. S.E. Handfield-Jones, N.P. Smith Malignant melanoma in childhood Br J Dermatol 134 1996 607 616
64. K.G. Lewis Trends in pediatric melanoma mortality in the United States, 1968 through 2004 Dermatol Surg 34 2008 152 159
65. Australian Cancer Network Melanoma Guidelines Revision Working Party Clinical Practice Guidelines for the Management of Melanoma in Australia and New Zealand 2008 Cancer Council Australia and Australian Cancer Network, Sydney and New Zealand Guidelines Group Wellington, AZ 1459
66. C.M. Balch, J.E. Gershenwald, S.J. Soong Final version of 2009 AJCC melanoma staging and classification J Clin Oncol 27 2009 6199 6206
67. F. Navid, W.L. Furman, M. Fleming The feasibility of adjuvant interferon alpha-2b in children with high-risk melanoma Cancer 103 2005 780 787
68. N.C. Shah, J.T. Gerstle, M. Stuart Use of sentinel lymph node biopsy and high-dose interferon in pediatric patients with high-risk melanoma: the Hospital for Sick Children experience J Pediatr Hematol Oncol 28 2006 496 500
69. C.M. Lohmann, D.G. Coit, M.S. Brady Sentinel lymph node biopsy in patients with diagnostically controversial spitzoid melanocytic tumors Am J Surg Pathol 26 2002 47 55
70. C. Urso, L. Borgognoni, M. Doria Non-sentinel lymph node involvement in a patient with an atypical Spitz' tumor and a positive sentinel node Report of a case and review of the literature J Cutan Pathol 36 2009 586 590
71. A. Alexander, W.E. Samlowski, D. Grossman Metastatic melanoma in pregnancy: risk of transplacental metastases in the infant J Clin Oncol 21 2003 2179 2186