α-Synuclein aggregation in the saliva of familial transthyretin amyloidosis: A potential biomarker

Amyloid

Volumn 19, Issue 2, 2012, Pages 74-80

  Guerreiro, Ana ^a   Da Costa, Gonçalo ^a   Gomes, Ricardo A ^b   Ribeiro Silva, Cristina ^a   Gilberto, Samuel ^a   Mateus, Élia ^c   Monteiro, Estela ^c   Barroso, Eduardo ^c   Coelho, Ana V ^b   Ponces Freire, Ana ^a   Cordeiro, Carlos ^a  

^a UNIVERSITY OF LISBON   (Portugal)

^b INSTITUTO DE TECNOLOGIA QUÍMICA E BIOLÓGICA   (Portugal)

^c HOSPITAL CURRY CABRAL   (Portugal)

Author keywords

synuclein; Familial transthyretin amyloidosis; Saliva; Systemic amyloidosis; Transthyretin

Indexed keywords

ALPHA SYNUCLEIN; AMYLASE; AMYLOID; CYSTATIN; PREALBUMIN; SECRETORY COMPONENT; SERUM ALBUMIN;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE CARRIER; DISEASE COURSE; FAMILIAL AMYLOIDOSIS; FAMILIAL TRANSTHYRETIN AMYLOIDOSIS; FEMALE; GENE MUTATION; HUMAN; HUMAN TISSUE; LIVER TRANSPLANTATION; MALE; MOLECULAR WEIGHT; OLIGOMERIZATION; PREDICTIVE VALUE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ANALYSIS; SALIVA; WESTERN BLOTTING;

ADOLESCENT; ADULT; ALPHA-SYNUCLEIN; AMINO ACID SEQUENCE; AMYLOID; AMYLOIDOSIS, FAMILIAL; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; DISEASE PROGRESSION; FEMALE; HETEROZYGOTE; HUMANS; LIVER TRANSPLANTATION; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PEPTIDE MAPPING; PREALBUMIN; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; SALIVA; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; YOUNG ADULT;

EID: 84861591302     PISSN: 13506129     EISSN: 17442818     Source Type: Journal    
DOI: 10.3109/13506129.2012.668500     Document Type: Article

References (24)

1. Benson, MD. The molecular basis of inherited disease, amyloidosis. Vol III, 7th ed. New York: McGraw-Hill; 1995. pp 4159.
2. Connors LH, Lim A, Prokaeva T, Roskens VA, Costello CE. Tabulation of human transthyretin (TTR) variants, 2003. Amyloid 2003;10:160-184.
3. Saraiva MJ, Costa PP, Goodman DS. Studies on plasma transthyretin (prealbumin) in familial amyloidotic polyneuropathy, Portuguese type. J Lab Clin Med 1983;102:590-603.
4. Saraiva MJ, Costa PP, Goodman DS. Biochemical marker in familial amyloidotic polyneuropathy, Portuguese type. Family studies on the transthyretin (prealbumin)-methionine-30 variant. J Clin Invest 1985;76:2171-2177.
5. Kelly JW, Colon W, Lai Z, Lashuel HA, McCulloch J, McCutchen SL, Miroy GJ, Peterson SA. Transthyretin quaternary and tertiary structural changes facilitate misassembly into amyloid. Adv Protein Chem 1997;50:161-181.
6. Andrade C. A peculiar form of peripheral neuropathy; familiar atypical generalized amyloidosis with special involvement of the peripheral nerves. Brain 1952;75:408-427.
7. Saraiva MJ, Birken S, Costa PP, Goodman DS. Amyloid fibril protein in familial amyloidotic polyneuropathy, Portuguese type. Definition of molecular abnormality in transthyretin (prealbumin). J Clin Invest 1984;74:104-119.
8. Lewis WD, Skinner M, Simms RW, Jones LA, Cohen AS, Jenkins RL. Orthotopic liver transplantation for familial amyloidotic polyneuropathy. Clin Transplant 1994;8:107-110.
9. Conceicao IM, Castro JF, Scotto M, de Carvalho M. Neurophysiological markers in familial amyloid polyneuropathy patients: early changes. Clin Neurophysiol 2008;119:1082-1087.
10. Devic I, Hwang H, Edgar JS, Izutsu K, Presland R, Pan C, Goodlett DR, et al. Salivary a-synuclein and DJ-1: potential biomarkers for Parkinson's disease. Brain 2011;134:e178.
11. Rosenfeld J, Capdevielle J, Guillemot JC, Ferrara P. In-gel digestion of proteins for internal sequence analysis after one- or two-dimensional gel electrophoresis. Anal Biochem 1992;203:173-179.
12. Lee HJ, Lee SJ. Characterization of cytoplasmic alpha-synuclein aggregates. Fibril formation is tightly linked to the inclusion-forming process in cells. J Biol Chem 2002;277:48976-48983.
13. Giasson BI, Uryu K, Trojanowski JQ, Lee VM. Mutant and wild type human alpha-synucleins assemble into elongated filaments with distinct morphologies in vitro. J Biol Chem 1999;274:7619-7622.
14. Holmgren G, Ericzon BG, Groth CG, Steen L, Suhr O, Andersen O, Wallin BG, et al. Clinical improvement and amyloid regression after liver transplantation in hereditary transthyretin amyloidosis. Lancet 1993;341:1113-1116.
15. Ericzon BG, Larsson M, Herlenius G, Wilczek HE; Familial Amyloidotic Polyneuropathy World Transplant Registry. Report from the Familial Amyloidotic Polyneuropathy World Transplant Registry (FAPWTR) and the Domino Liver Transplant Registry (DLTR). Amyloid 2003;10 Suppl 1:67-76.
16. Monteiro E, Freire A, Barroso E. Familial amyloid polyneuropathy and liver transplantation. J Hepatol 2004;41:188-194.
17. Adams D, Samuel D, Goulon-Goeau C, Nakazato M, Costa PM, Feray C, Plante V, et al. The course and prognostic factors of familial amyloid polyneuropathy after liver transplantation. Brain 2000;123 (Pt 7):1495-1504.
18. Tashima K, Ando Y, Terazaki H, Yoshimatsu S, Suhr OB, Obayashi K, Yamashita T, et al. Outcome of liver transplantation for transthyretin amyloidosis: follow-up of Japanese familial amyloidotic polyneuropathy patients. J Neurol Sci 1999;171:19-23.
19. de Carvalho M, Conceicao I, Bentes C, Luis ML. Long-term quantitative evaluation of liver transplantation in familial amyloid polyneuropathy (Portuguese V30M). Amyloid 2002;9:126-133.
20. Yamamoto S, Wilczek HE, Nowak G, Larsson M, Oksanen A, Iwata T, Gjertsen H, et al. Liver transplantation for familial amyloidotic polyneuropathy (FAP): a single-center experience over 16 years. Am J Transplant 2007;7:2597-2604.
21. da Costa G, Gomes R, Correia CF, Freire A, Monteiro E, Martins A, Barroso E, et al. Identification and quantitative analysis of human transthyretin variants in human serum by Fourier transform ion-cyclotron resonance mass spectrometry. Amyloid 2009;16: 201-207.
22. El-Agnaf OM, Salem SA, Paleologou KE, Curran MD, Gibson MJ, Court JA, Schlossmacher MG, Allsop D. Detection of oligomeric forms of alpha-synuclein protein in human plasma as a potential biomarker for Parkinson's disease. FASEB J 2006;20:419-425.
23. Tokuda T, Qureshi MM, Ardah MT, Varghese S, Shehab SA, Kasai T, Ishigami N, et al. Detection of elevated levels of a-synuclein oligomers in CSF from patients with Parkinson disease. Neurology 2010;75:1766-1772.
24. Ballard CG, Jones EL. CSF a-synuclein as a diagnostic biomarker for Parkinson disease and related dementias. Neurology 2010;75:1760-1761.