Apolipoprotein e genotype predicts hematoma expansion in lobar intracerebral hemorrhage

Stroke

Volumn 43, Issue 6, 2012, Pages 1490-1495

  Brouwers, H Bart ^a,b,c,d   Biffi, Alessandro ^a,b,c,d,g   Ayres, Alison M ^c,d   Schwab, Kristin ^c,d   Cortellini, Lynelle ^a,b,c,d,g   Romero, Javier M ^e   Rost, Natalia S ^a,b,c,d,g   Viswanathan, Anand ^b,c,d   Greenberg, Steven M ^c,d   Rosand, Jonathan ^a,b,c,d,g   Goldstein, Joshua N ^b,c,d,f  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b Division of Neurocritical Care and Emergency Neurology   (United States)

^c Hemorrhagic Stroke Research Group   (United States)

^d J Philip Kistler Stroke Research Center   (United States)

^e Neuroradiology Service   (United States)

^f HARVARD MEDICAL SCHOOL   (United States)

^g BROAD INSTITUTE OF MIT AND HARVARD   (United States)

Author keywords

APOE; cerebral amyloid angiopathy; genetics; hematoma expansion; intracerebral hemorrhage

Indexed keywords

APOLIPOPROTEIN E; APOLIPOPROTEIN E2; APOLIPOPROTEIN E4;

AGED; ALLELE; ARTICLE; BRAIN HEMATOMA; BRAIN HEMORRHAGE; COMPUTER ASSISTED TOMOGRAPHY; FEMALE; FOLLOW UP; GENETIC RISK; GENOTYPE; HIGH RISK PATIENT; HUMAN; MAJOR CLINICAL STUDY; MALE; PREDICTOR VARIABLE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; VASCULAR AMYLOIDOSIS;

AGED; AGED, 80 AND OVER; ALLELES; APOLIPOPROTEINS E; CEREBRAL HEMORRHAGE; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HEMATOMA; HUMANS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; RETROSPECTIVE STUDIES;

EID: 84861581578     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/STROKEAHA.111.643262     Document Type: Article

References (26)

1. Biffi A, Sonni A, Anderson CD, Kissela B, Jagiella JM, Schmidt H, et al. International Stroke Genetics Consortium. Variants at APOE influence risk of deep and lobar intracerebral hemorrhage. Ann Neurol. 2010;68: 934-943.
2. Vinters HV. Cerebral amyloid angiopathy. A critical review. Stroke. 1987;18:311-324.
3. Pezzini A, Padovani A. Cerebral amyloid angiopathy-related hemorrhages. Neurol Sci. 2008;29(suppl 2):S260-263.
4. Greenberg SM, Vonsattel JP, Segal AZ, Chiu RI, Clatworthy AE, Liao A, et al. Association of apolipoprotein E epsilon2 and vasculopathy in cerebral amyloid angiopathy. Neurology. 1998;50:961-965.
5. McCarron MO, Nicoll JA, Stewart J, Ironside JW, Mann DM, Love S, et al. The apolipoprotein E epsilon2 allele and the pathological features in cerebral amyloid angiopathy-related hemorrhage. J Neuropathol Exp Neurol. 1999;58:711-718.
6. Biffi A, Anderson CD, Jagiella JM, Schmidt H, Kissela B, Hansen BM, et al; on behalf of the International Stroke Genetics Consortium. APOE genotype and extent of bleeding and outcome in lobar intracerebral haemorrhage: a genetic association study. Lancet Neurol. 2011;10: 702-709.
7. Brott T, Broderick J, Kothari R, Barsan W, Tomsick T, Sauerbeck L, et al. Early hemorrhage growth in patients with intracerebral hemorrhage. Stroke. 1997;28:1-5.
8. Mayer SA. Ultra-early hemostatic therapy for intracerebral hemorrhage. Stroke. 2003;34:224-229.
9. Flibotte JJ, Hagan N, O'Donnell J, Greenberg SM, Rosand J. Warfarin, hematoma expansion, and outcome of intracerebral hemorrhage. Neurology. 2004;63:1059-1064.
10. Dowlatshahi D, Demchuk AM, Flaherty ML, Ali M, Lyden PL, Smith EE, VISTA Collaboration. Defining hematoma expansion in intracerebral hemorrhage: relationship with patient outcomes. Neurology. 2011;76: 1238-1244.
11. Davis SM, Broderick J, Hennerici M, Brun NC, Diringer MN, Mayer SA, et al. Recombinant Activated Factor VII Intracerebral Hemorrhage Trial Investigators. Hematoma growth is a determinant of mortality and poor outcome after intracerebral hemorrhage. Neurology. 2006;66:1175-1181.
12. Mayer SA, Brun NC, Begtrup K, Broderick J, Davis S, Diringer MN, et al. FAST Trial Investigators. Efficacy and safety of recombinant activated factor VII for acute intracerebral hemorrhage. N Engl J Med. 2008;358: 2127-2137.
13. Anderson CS, Huang Y, Wang JG, Arima H, Neal B, Peng B, et al. INTERACT Investigators. Intensive blood pressure reduction in acute cerebral haemorrhage trial (INTERACT): a randomised pilot trial. Lancet Neurol. 2008;7:391-399.
14. Qureshi AI, Tuhrim S, Broderick JP, Batjer HH, Hondo H, Hanley DF. Spontaneous intracerebral hemorrhage. N Engl J Med. 2001;344: 1450-1460.
15. Knudsen KA, Rosand J, Karluk D, Greenberg SM. Clinical diagnosis of cerebral amyloid angiopathy: validation of the Boston criteria. Neurology. 2001;56:537-539.
16. Greenberg SM, Vonsattel JP. Diagnosis of cerebral amyloid angiopathy. Sensitivity and specificity of cortical biopsy. Stroke. 1997;28:1418-1422.
17. Greenberg SM, Rebeck GW, Vonsattel JP, Gomez-Isla T, Hyman BT. Apolipoprotein E epsilon 4 and cerebral hemorrhage associated with amyloid angiopathy. Ann Neurol. 1995;38:254-259.
18. Greenberg SM, Vernooij MW, Cordonnier C, Viswanathan A, Al-Shahi Salman R, Warach S, et al. Microbleed Study Group. Cerebral microbleeds: a guide to detection and interpretation. Lancet Neurol. 2009;8: 165-174.
19. Janssen PM, Visser NA, Dorhout Mees SM, Klijn CJ, Algra A, Rinkel GJ. Comparison of telephone and face-to-face assessment of the modified Rankin Scale. Cerebrovasc Dis. 2010;29:137-139.
20. Delgado Almandoz JE, Yoo AJ, Stone MJ, Schaefer PW, Goldstein JN, Rosand J, et al. Systematic characterization of the computed tomography angiography spot sign in primary intracerebral hemorrhage identifies patients at highest risk for hematoma expansion: the spot sign score. Stroke. 2009;40:2994-3000.
21. Delgado Almandoz JE, Yoo AJ, Stone MJ, Schaefer PW, Oleinik A, Brouwers HB, et al. The spot sign score in primary intracerebral hemorrhage identifies patients at highest risk of in-hospital mortality and poor outcome among survivors. Stroke. 2010;41:54-60.
22. Goldstein JN, Fazen LE, Snider R, Schwab K, Greenberg SM, Smith EE, et al. Contrast extravasation on CT angiography predicts hematoma expansion in intracerebral hemorrhage. Neurology. 2007;68:889-894.
23. Cucchiara B, Messe S, Sansing L, Kasner S, Lyden P, CHANT Investigators. Hematoma growth in oral anticoagulant related intracerebral hemorrhage. Stroke. 2008;39:2993-2996.
24. Fisher CM. Pathological observations in hypertensive cerebral hemorrhage. J Neuropathol Exp Neurol. 1971;30:536-550.
25. Montaner J. Genetics of intracerebral haemorrhage: a tsunami effect of APOE2 genotype on brain bleeding size? Lancet Neurol. 2011;10: 673-675.
26. Wada R, Aviv RI, Fox AJ, Sahlas DJ, Gladstone DJ, Tomlinson G, et al. CT angiography 'spot sign' predicts hematoma expansion in acute intracerebral hemorrhage. Stroke. 2007;38:1257-1262.