Genetics of intracerebral haemorrhage: A tsunami effect of APOE e{open}2 genotype on brain bleeding size?

The Lancet Neurology

Volumn 10, Issue 8, 2011, Pages 673-675

  Montaner, Joan ^a  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; APOLIPOPROTEIN E2; APOLIPOPROTEIN E4; BIOLOGICAL MARKER; GELATINASE B; HEMOSTATIC AGENT; ISOPROTEIN; TISSUE PLASMINOGEN ACTIVATOR;

AFRICAN AMERICAN; BLOOD CLOT LYSIS; BRAIN HEMATOMA; BRAIN HEMORRHAGE; BRAIN REGION; CAUCASIAN; CLINICAL ASSESSMENT; COMPUTED TOMOGRAPHIC ANGIOGRAPHY; CONTROLLED STUDY; DISEASE COURSE; GENE DOSAGE; GENE EXPRESSION; GENE REPLICATION; GENETIC ASSOCIATION; GENETIC RISK; GENETICS; GENOTYPE; HETEROZYGOTE; HUMAN; INCIDENCE; LETTER; MACROPHAGE; MAJOR CLINICAL STUDY; MORTALITY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RISK ASSESSMENT; SCIENTIFIC LITERATURE; VASCULAR AMYLOIDOSIS;

APOLIPOPROTEIN E2; BRAIN; CEREBRAL HEMORRHAGE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; TSUNAMIS;

EID: 79960348625     PISSN: 14744422     EISSN: 14744465     Source Type: Journal    
DOI: 10.1016/S1474-4422(11)70157-0     Document Type: Letter

References (11)

1. Steiner T, Petersson J, Al-Shahi Salman R, et al, for the European Research Network on Intracerebral Haemorrhage (EURONICH). European research priorities for intracerebral haemorrhage. Cerebrovasc Dis (in press).
2. Rost NS, Greenberg SM, Rosand J The genetic architecture of intracerebral hemorrhage. Stroke 2008, 39:2166-2173.
3. Biffi A, Sonni A, Anderson CD, et al. Variants at APOE influence risk of deep and lobar intracerebral hemorrhage. Ann Neurol 2010, 68:934-943. International Stroke Genetics Consortium.
4. Biffi A, Anderson CD, Jagiella JM, et al. APOE genotype and extent of bleeding and outcome in lobar intracerebral haemorrhage: a genetic association study. Lancet Neurol 2011, on behalf of the International Stroke Genetics Consortium, published online July 7. 10.1016/S1474-4422(11)70148-X.
5. Greenberg SM, Vonsattel JP, Segal AZ, et al. Association of apolipoprotein E e{open}2 and vasculopathy in cerebral amyloid angiopathy. Neurology 1998, 50:961-965.
6. Clark JF, Huri DA, Carrozzella J, et al. Isoforms of apolipoprotein E can modulate tPA-induced clot lysis in vitro. Front Biosci 2002, 1:163-168.
7. Zhao L, Lin S, Bales KR, et al. Macrophage-mediated degradation of β-amyloid via an apolipoprotein E isoform-dependent mechanism. J Neurosci 2009, 29:3603-3612.
8. Hernandez-Guillamon M, Martinez-Saez E, Delgado P, et al. MMP-2/MMP-9 plasma level and brain expression in cerebral amyloid angiopathy-associated hemorrhagic stroke. Brain Pathol 2011, published online June 27. 10.1111/j.1750-3639.2011.00512.x.
9. Wada R, Aviv RI, Fox AJ, et al. CT angiography "spot sign" predicts hematoma expansion in acute intracerebral hemorrhage. Stroke 2007, 38:1257-1262.
10. Mayer SA, Davis SM, Skolnick BE, et al. Can a subset of intracerebral hemorrhage patients benefit from hemostatic therapy with recombinant activated factor VII?. Stroke 2009, 3:833-840.
11. Brown WM, Biffi A, Jagiella JM, et al. Genome-wide association study of intracerebral hemorrhage. Stroke 2011, 42:e218. (abstr).