Synthesis and antiviral evaluation of C5-substituted-(1,3-diyne)-2′- deoxyuridines

European Journal of Medicinal Chemistry

Volumn 53, Issue , 2012, Pages 220-228

  Sari, Ozkan ^a   Roy, Vincent ^a   Balzarini, Jan ^b   Snoeck, Robert ^b   Andrei, Graciela ^b   Agrofoglio, Luigi A ^a  

^a Université d'Orléans   (France)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Anti VZV activity; Diyne scaffold; Nickel copper catalyzed C H activation; Nucleoside

Indexed keywords

5 (4 PHENYLBUTA 1,3 DIYNYL) 2' DEOXYURIDINE; 5 (6 HYDROXYHEPTA 1,3 DIYNYL) 2'' DEOXYURIDINE; 5 [4 (3 AMINOPHENYL)BUTA 1,3 DIYNYL] 2'' DEOXYURIDINE; 5 [4 (3,5 DIMETHOXYPHENYL)BUTA 1,3 DIYNYL] 2'' DEOXYURIDINE; 5 [4 (4 AMINOPHENYL)BUTA 1,3 DIYNYL] 2'' DEOXYURIDINE; 5 [4 (4 FLUORO 3 METHYLPHENYL)BUTA 1,3 DIYNYL] 2'' DEOXYURIDINE; 5 [4 (4 HEXYLPHENYL)BUTA 1,3 DIYNYL] 2'' DEOXYURIDINE; 5 [4 (4 NITROPHENYL)BUTA 1,3 DIYNYL] 2'' DEOXYURIDINE; 5 [4 (4 PROPYLPHENYL)PHENYLBUTA 1,3 DIYNYL] 2'' DEOXYURIDINE; 5 [4 (4 TRIFLUOROMETHOXYPHENYL)BUTA 1,3 DIYNYL] 2' DEOXYURIDINE; 5 [4 (CYCLOPROPYL)BUTA 1,3 DIYNYL] 2'' DEOXYURIDINE; 5 [4 (PYRIDIN 2 YL)BUTA 1,3 DIYNYL] 2'' DEOXYURIDINE; 5 [5 CYCLOPENTYLPENTA 1,3 DIYNYL] 2'' DEOXYURIDINE; 5 [5 HYDROPENTA1,3 DIYNYL] 2'' DEOXYURIDINE; 5 ETHYNYLDEOXYURIDINE; ALKYNE DERIVATIVE; ANTIVIRUS AGENT; C5 SUBSTITUTED(1,3 DIYNE) 2' DEOXYURIDINE; COPPER; DEOXYURIDINE DERIVATIVE; NICKEL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CATALYSIS; CELL CULTURE; CELL STRAIN; CONTROLLED STUDY; COXSACKIE VIRUS B4; CYTOMEGALOVIRUS; CYTOSTASIS; DNA VIRUS; DRUG SCREENING; DRUG SYNTHESIS; HELA CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; INFLUENZA VIRUS A H1N1; INFLUENZA VIRUS A H3N2; LEUKEMIA CELL; MAMMALIAN ORTHOREOVIRUS; NONHUMAN; PARAINFLUENZA VIRUS 3; PUNTA TORO VIRUS; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; RNA VIRUS; SINDBIS VIRUS; SUBSTITUTION REACTION; T LYMPHOCYTE; UTERINE CERVIX CARCINOMA; VACCINIA VIRUS; VERO CELL; VESICULAR STOMATITIS VIRUS;

ANTIVIRAL AGENTS; CELL LINE; CHEMISTRY TECHNIQUES, SYNTHETIC; DEOXYURIDINE; HUMANS; INHIBITORY CONCENTRATION 50; VIRUS REPLICATION; VIRUSES;

EID: 84861581552     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.04.001     Document Type: Article

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