Discovery, synthesis, and biological evaluation of novel pyrrole derivatives as highly selective potassium-competitive acid blockers

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 12, 2012, Pages 3925-3938

  Nishida, Haruyuki ^a,b   Hasuoka, Atsushi ^a   Arikawa, Yasuyoshi ^a   Kurasawa, Osamu ^a   Hirase, Keizo ^a   Inatomi, Nobuhiro ^a   Hori, Yasunobu ^a   Sato, Fumihiko ^a   Tarui, Naoki ^a   Imanishi, Akio ^a   Kondo, Mitsuyo ^a   Takagi, Terufumi ^a   Kajino, Masahiro ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

^b NONE   (Japan)

Author keywords

Potassium competitive acid blocker; Pyrrole

Indexed keywords

1 (1 BENZYL 5 PHENYL 1H PYRROL 3 YL) N METHYLMETHANAMINE; 1 [( METHYLPHENYL)SULFONYL] 5 PHENYL 1H PYRROLE 3 CARBOXAMIDE; 1 [1 (BUTYLSULFONYL) 5 PHENYL 1H PYRROL 3 YL] N METHYLMETHANAMINE HEMI OXALATE; 1 [1 [(4 METHYLPHENYL)SULFONYL] 5 PHENYL 1H PYRROL 3 YL] N METHYLMETHANAMINE; 1 [1 [(4 METHYLPHENYL)SULFONYL] 5 PHENYL 1H PYRROL 3 YL]METHANAMINE; 1 [2 CHLORO 5 PHENYL 1 (PHENYLSULFONYL) 1H PYRROL 3 YL] N METHYLMETHANAMINE; 1 [5 BUTYL 1 (PHENYLSULFONYL) 1H PYRROL 3 YL] N METHYLMETHANAMINE; 1 [5 CYCLOPROPYL 1 (PHENYLSULFONYL) 1H PYRROL 3 YL] N METHYLMETHANAMINE; 2 CHLOROL 5 PHENYL 1 (PHENYLSULFONYL) 1H PYRROLE 3 CARBALDEHYDE; 2 METHYL 5 PHENYL 1 (PHENYLSULFONYL) 1H PYRROLE 3 CARBALDEHYDE; 4 (METHOXYMETHYL) 1 [(4 METHYLPHENYL)SULFONYL] 2 PHENYL 1H PYRROLE; HISTAMINE; HYDROGEN POTASSIUM ADENOSINE TRIPHOSPHATASE; METHYL 4 METHYL 5 PHENYL 1 (PHENYLSULFONYL) 1H PYRROLE 3 CARBOXYLATE; METHYL 5 BROMO 4 METHYL 1 (PHENYLSULFONYL) 1H PYRROLE 3 CARBOXYLATE; METHYL 5 BROMO 4 METHYL 1H PYRROLE 3 CARBOXYLATE; N METHYL 1 [1 (METHYLSULFONYL) 5 PHENYL 1H PYRROL 3 YL]METHANAMINE; N METHYL 1 [1 [(4 METHYLPHENYL)SULFONYL] 5 PHENYL 1H PYRROL 3 YL]METHANAMINE; N METHYL 1 [2 METHYL 5 PHENYL 1 (PHENYLSULFONYL) 1H PYRROL 3 YL]METHANAMINE; N METHYL 1 [4 METHYL 5 PHENYL 1 (PHENYLSULFONYL) 1H PYRROL 3 YL]METHANAMINE; N METHYL 1 [5 PHENYL 1 (PHENYLSULFONYL) 1H PYRROL 3 YL]METHANAMINE; N METHYL 1 [5 PHENYL 1 [[4 (TRIFLUOROMETHYL)PHENYL]SULFONYL] 1H PYRROL 3 YL]ETHANAMINE; N METHYL 1 [5 PHENYL 1 [[4 (TRIFLUOROMETHYL)PHENYL]SULFONYL] 1H PYRROL 3 YL]METHANAMINE; N [[1 [(4 METHYLPHENYL)SULFONYL] 5 PHENYL 1H PYRROL 3 YL]METHYL]ETHANAMINE; N,N DIMETHYL 1 [5 PHENYL 1 [[4 (TRIFLUOROMETHYL)PHENYL]SULFONYL] 1H PYRROL 3 YL]METHANAMINE; POTASSIUM COMPETITIVE ACID BLOCKER; POTASSIUM ION; PYRROLE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; [4 [(METHYLAMINO)METHYL] 2 PHENYL 1H PYRROL 1 YL](PHENYL)METHANONE FUMARATE;

ANIMAL CELL; ANIMAL EXPERIMENT; CHEMICAL BOND; CONFERENCE PAPER; CONTROLLED STUDY; DRUG ACTIVITY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; MALE; NONHUMAN; RAT; STOMACH ACID SECRETION;

CANIS FAMILIARIS; RATTUS;

EID: 84861577968     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.04.014     Document Type: Conference Paper

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