The discovery and development of selective 3-fluoro-4-aryloxyallylamine inhibitors of the amine oxidase activity of semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 (SSAO/VAP-1)

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 12, 2012, Pages 3935-3940

  Foot, Jonathan S ^a   Deodhar, Mandar ^a   Turner, Craig I ^a   Yin, Ping ^a   Van Dam, Ellen M ^a   Silva, Diego G ^a   Olivieri, Aldo ^b   Holt, Andrew ^b   McDonald, Ian A ^a  

^a Pharmaxis Ltd   (Australia)

^b UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Allylamines; Amine oxidase; SSAO; VAP 1

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING); LJP 1586; MOFEGILINE; MONOAMINE OXIDASE INHIBITOR; PXS 4159A; SEMICARBAZIDE; UNCLASSIFIED DRUG; VASCULAR ADHESION PROTEIN 1;

ARTICLE; CRYSTAL STRUCTURE; DRUG ACTIVITY; DRUG BINDING; DRUG MECHANISM; DRUG POTENCY; ENZYME ACTIVITY; NONHUMAN; PARKINSON DISEASE; PNEUMONIA; STRUCTURE ACTIVITY RELATION;

ALLYL COMPOUNDS; AMINE OXIDASE (COPPER-CONTAINING); AMINES; ANIMALS; ANTI-INFLAMMATORY AGENTS; DRUG DISCOVERY; HALOGENATION; HUMANS; ISOENZYMES; MICE; MODELS, MOLECULAR; MONOAMINE OXIDASE INHIBITORS; PNEUMONIA; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

MURINAE; RATTUS;

EID: 84861577039     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.04.111     Document Type: Article

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