Chemical characterisation and determination of sensory attributes of hydrolysates produced by enzymatic hydrolysis of whey proteins following a novel integrative process

Food Chemistry

Volumn 134, Issue 4, 2012, Pages 1947-1958

  Welderufael, Fisseha Tesfay ^a   Gibson, Trevor ^a   Methven, Lisa ^a   Jauregi, Paula ^a  

^a UNIVERSITY OF READING   (United Kingdom)

Author keywords

Lactoglobulin; ACE inhibitory peptides; Bitterness; Casein derived peptides; Ion exchange resin; Protease N 'Amano'

Indexed keywords

ACE-INHIBITORY; ANGIOTENSIN-CONVERTING ENZYME; BITTERNESS; IMMOBILISATION; IN-SITU; INHIBITORY PEPTIDES; LACTOGLOBULIN; PEPTIDE PRODUCTS; PROTEASE N 'AMANO'; SENSORY ATTRIBUTES; STIRRED CELLS; STRUCTURAL SIMILARITY; WHEY PROTEINS;

ADSORPTION; CASEIN; ENZYMATIC HYDROLYSIS; FRACTIONATION; ION EXCHANGE RESINS; MICROFILTRATION;

PEPTIDES;

BETA LACTOGLOBULIN; CASEIN; CHYMOTRYPSIN; COLORASE PP; DIPEPTIDYL CARBOXYPEPTIDASE; ENZYME; PEPSIN A; PROTEIN; PROTEIN HYDROLYSATE; TRYPSIN; UNCLASSIFIED DRUG; WHEY PROTEIN;

ADSORPTION; ARTICLE; BITTER TASTE; COMPUTER MODEL; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ELECTROSPRAY MASS SPECTROMETRY; ENZYME IMMOBILIZATION; ENZYME INHIBITION; ENZYME STABILITY; FRACTIONATION; HYDROLYSIS; IC 50; MICROFILTRATION; ORGANOLEPTIC PROPERTY; PEPTIDE ANALYSIS; REVERSED PHASE LIQUID CHROMATOGRAPHY; SEPARATION TECHNIQUE; SEQUENCE ANALYSIS; STRUCTURAL HOMOLOGY; STRUCTURE ACTIVITY RELATION; TANDEM MASS SPECTROMETRY; TIME OF FLIGHT MASS SPECTROMETRY; ULTRAFILTRATION; WHEY;

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANTIHYPERTENSIVE AGENTS; HUMANS; HYDROLYSIS; MASS SPECTROMETRY; MILK PROTEINS; PEPTIDE MAPPING; PEPTIDES; PROTEIN HYDROLYSATES; TASTE;

EID: 84861576438     PISSN: 03088146     EISSN: 18737072     Source Type: Journal    
DOI: 10.1016/j.foodchem.2012.03.113     Document Type: Article

References (42)

1. A. Abubakar, T. Saito, H. Kitazawa, Y. Kawai, and T. Itoh Structural analysis of new antihypertensive peptides derived from cheese whey protein by proteinase K digestion Journal of Dairy Science 81 1998 3131 3138 (Pubitemid 128444864)
2. E.D. Bastian, and R.J. Brown Plasmin in milk and dairy products: An update: Review article International Dairy Journal 6 1996 435 457 (Pubitemid 27084443)
3. C. Ceconi, G. Francolini, A. Olivares, L. Comini, T. Bachetti, and R. Ferrari Angiotensin-converting enzyme (ACE) inhibitors have different selectivity for bradykinin binding sites of human somatic ACE European Journal of Pharmacology 577 2007 1 6 (Pubitemid 47632513)
4. S.C. Cheison, Z. Wang, and S.Y. Xu Use of macroporous adsorption resin for simultaneous desalting and debittering of whey protein hydrolysates International Journal of Food Science and Technology 42 2007 1228 1239 (Pubitemid 47404361)
5. I.W.Y. Cheung, and E.C.Y. Li-Chan Angiotensin-I-converting enzyme inhibitory activity and bitterness of enzymatically-produced hydrolysates of shrimp (Pandalopsis dispar) processing by products investigated by Taguchi design Food Chemistry 122 2010 1003 1012
6. H.-S. Cheung, F.-L. Wang, M. Ondetti, E. Sabo, and D. Cushman Binding of Peptide Substrates and Inhibitors of Angiotensin-converting Enzyme: Importance of the COOH- terminal dipeptide sequences The Journal of Biological Chemistry 255 1980 401 407
7. L.J. Coppey, E.P. Davidson, T.W. Rinehart, J.S. Gellett, C.L. Oltman, and D.D. Lund ACE inhibitor or angiotensin II receptor antagonist attenuates diabetic neuropathy in streptozotocin-induced diabetic rats Diabetes 55 2006 341 348 (Pubitemid 43343262)
8. P.I. Ehlers, L. Nurmi, A.M. Turpeinen, R. Korpela, and H. Vapaatalo Casein-derived tripeptide Ile-Pro-Pro improves angiotensin-(1-7)- and bradykinin-induced rat mesenteric artery relaxation Life Sciences 88 2011 206 211
9. S.H. Ferreira A bradykinin-potentiating factor (BPF) present in the venom of Bothrops jararaca British Journal of Pharmacology and Chemotherapy 24 1965 163 169
10. Fox, P. (1993) Studies on Dairy Chemistry: Chemistry and Biochemistry of Cheese. PhD Thesis, Cork, University College Cork.
11. M. Gobbetti, P. Ferranti, E. Smacchi, F. Goffredi, and F. Addeo Production of angiotensin-I-converting enzyme inhibitoy peptides in fermented milks started by Lactobacillus delbrueckii subsp. bulgaricus SS1 and Lactococcus lactis subsp. cremoris FT4 Applied and Environmental Microbiology 66 2000 3898 3904
12. B. Hernandez-Ledesma, I. Recio, M. Ramos, and L. Amigo Preparation of ovine and caprine β-lactoglobulin hydrolysates with ACE-inhibitory activity. Identification of active peptides from caprine β-lactoglobulin hydrolysed with thermolysin International Dairy Journal 12 2002 805 812 (Pubitemid 35169483)
13. C.K. Hyun, and H.K. Shin Utilization of bovine blood plasma proteins for the production of angiotensin I converting enzyme inhibitory peptide Process Biochemistry 36 2000 65 71
14. P. Jauregi Bioactive peptides from food proteins: New opportunities and challenges: A review Food Science and Technology/Bulletin 5 2008 11 25
15. P. Jauregi, and F.T. Welderufael Added-value protein products from whey NUTRAfoods 9 2010 13 23
16. J.-Y. Je, P.-J. Park, H.-G. Byun, W.-K. Jung, and S.-K. Kim Angiotensin I converting enzyme (ACE) inhibitory peptide derived from the sauce of fermented blue mussel, Mytilus edulis Bioresource Technology 96 2005 1624 1629 (Pubitemid 40840711)
17. A. Kilara, and D. Panyam Peptides from milk proteins and their properties Critical Reviews in Food Science and Nutrition 43 2003 607 633 (Pubitemid 38552292)
18. H. Korhonen, and A. Pihlanto Bioactive peptides: Production and functionality International Dairy Journal 16 2006 945 960 (Pubitemid 44255683)
19. G.A. Linde, A.L. Junior, E.V.d. Faria, N.B. Colauto, F.F.d. Moraes, and G.M. Zanin Taste modification of amino acids and protein hydrolysate by α-Cyclodextrin Food Research International 42 2009 814 818
20. R. Lopez-Fandino, J. Otte, and J. van Camp Physiological, chemical and technological aspects of milk-protein-derived peptides with antihypertensive and ACE-inhibitory activity International Dairy Journal 16 2006 1277 1293 (Pubitemid 44331581)
21. M. Miguel, M.A. Manso, R. Lopez-Fandino, M.J. Alonso, and M. Salaices Vascular effects and antihypertensive properties of κ-casein macropeptide International Dairy Journal 17 2007 1473 1477 (Pubitemid 47380328)
22. M.M. Mullally, H. Meisel, and R.J. FitzGerald Angiotensin-I-converting enzyme inhibitory activities of gastric and pancreatic Proteinase digests of whey proteins International Dairy Journal 7 1997 299 303 (Pubitemid 28042753)
23. M.M. Mullally, H. Meisel, and R.J. FitzGerald Identification of a novel angiotensin-I-converting enzyme inhibitory peptide corresponding to a tryptic fragment of bovine β-lactoglobulin FEBS Letters 402 1997 99 101 (Pubitemid 27078237)
24. S. Nagaoka, Y. Futamura, K. Miwa, T. Awano, K. Yamauchi, and Y. Kanamaru Identification of novel hypocholesterolemic peptides derived from bovine milk β-lactoglobulin Biochemical and Biophysical Research communications 281 2001 11 17 (Pubitemid 32924392)
25. Y. Nakamura, N. Yamamoto, K. Sakai, A. Okubo, S. Yamazaki, and T. Takano Purification and characterisation of angiotensin I-converting enzyme inhibitors from sour milk Journal of Dairy Science 78 1995 777 783
26. Ortiz-Chao, P. (2008). β-lactoglobulin derived bioactive peptides: A study of the feasibility of an ion exchange process for their production. Food Biosciences, PhD Thesis. Reading: Reading University.
27. P. Ortiz-Chao, J.A. Gomez-Ruiza, R.A. Rastalla, D. Millsb, R. Cramerb, and A. Pihlantoc Production of novel ACE inhibitory peptides from β-lactoglobulin using Protease N 'Amano' International Dairy Journal 19 2009 69 76
28. K. Otagiri, Y. Nosho, and I. Shinoda Studies on a model of bitter peptides including arginine, proline and phenylalanine residues. I. Bitter taste of di- and tripeptides, and bitterness increase of the model peptides by extension of the peptide chain Agricultural and Biological chemistry 49 1985 1019 1102
29. J. Otte, S.M. Shalaby, M. Zakora, A.H. Pripp, and S.A. El-Shabrawy Angiotensin-converting enzyme inhibitory activity of milk protein hydrolysates: Effect of substrate, enzyme and time of hydrolysis International Dairy Journal 17 2007 488 503 (Pubitemid 46043426)
30. J. Pedroche, M.M. Yust, H. Lqari, C. Megias, J. Giron-Calle, and M. Alaiz Obtaining of Brassica carinata protein hydrolysates enriched in bioactive peptides using immobilized digestive proteases Food Research International 40 2007 931 938 (Pubitemid 46990910)
31. A. Pihlanto-Leppala, P. Koskinen, K. Piilola, T. Tupasela, and H. Korhonen Angiotensin-I-converting enzyme inhibitory properties of whey protein digests. Concentration and characterisation of active peptides Journal of Dairy Research 67 2000 53 64 (Pubitemid 30104846)
32. A.H. Pripp, T. Isaksson, L. Stepaniak, T. Sorhaug, and Y. Ardö Quantitative structure activity relationship modelling of peptides and proteins as a tool in food science Trends in Food Science and Technology 16 2005 484 494 (Pubitemid 41528783)
33. A. Quiros, M. del Mar Contreras, M. Ramos, L. Amigo, and I. Recio Stability to gastrointestinal enzymes and structure-activity relationship of β-casein peptides with antihypertensive properties Peptides 30 2009 1848 1853
34. A. Quiros, B. Hernandez-Ledesma, M. Ramos, L. Amigo, and I. Recio Angiotensin-converting enzyme inhibitory activity of peptides derived from Caprine Kefir Journal of Dairy Science 88 2005 3480 3487 (Pubitemid 41624074)
35. Schlothauer, R.-C., Schollum, L., Singh, A., & Reid, J. (1999). Bioactive whey protein hydrolysate. World Patent WO 99/65326.
36. K. Suetsuna, and J.R. Chen Identification of antihypertensive peptides from peptic digests of two microalgae, Chlorella vulgaris and Spirulina platensis Marine Biotechnology 3 2001 305 309 (Pubitemid 32925885)
37. I. Toshiaki, H. Jianen, Q.A. Duong, and M. Susumu Angiotensin I converting enzyme inhibitory activity and insulin secretion stimulative activity of fermented fish sauce Journal of Biosciences and Bioengineering 96 2003 496 499
38. V. Vermeirssen, A.v.d. Bent, J.V. Camp, A.v. Amerongen, and W. Verstraete A quantitative in silico analysis calculates the angiotensin I converting enzyme (ACE) inhibitory activity in pea and whey protein digests Biochimie 86 2004 231 239 (Pubitemid 38591511)
39. D.J. Walsh, H. Bernard, B.A. Murray, J. MacDonald, A.-K. Pentzien, and G.A. Wright In Vitro Generation and Stability of the Lactokinin β-Lactoglobulin Fragment (142-148) Journal of Dairy Science 87 2004 3845 3857 (Pubitemid 39474558)
40. Welderufael, F. T., Gibson, T., Jauregi, P. (2012). Production of angiotensin converting enzyme inhibitory peptides from β-lactoglobulin and casein derived peptides: an integrative approach. Biotechnology Progress. http://dx.doi.org/10.1002/btpr.1541.
41. F. Welderufael, and P. Jauregi Development of an integrative process for the production of bioactive peptides from whey by proteolytic mixtures Separation Science and Technology 45 2010 2226 2234
42. J. Wu, R.E. Aluko, and S. Nakai Structural requirements of angiotensin I converting enzyme inhibitory peptides: Quantitative structure-activity relationship study of Di- and Tripeptides Journal of Agricultural Food Chemistry 54 2006 732 738 (Pubitemid 43274109)