Probability of C282Y homozygosity decreases as liver transaminase activities increase in participants with hyperferritinemia in the hemochromatosis and iron overload screening study

Hepatology

Volumn 55, Issue 6, 2012, Pages 1722-1726

  Adams, Paul C ^a   Speechley, Mark ^b   Barton, James C ^c   McLaren, Christine E ^d   McLaren, Gordon D ^d,e   Eckfeldt, John H ^f  

^a LONDON HEALTH SCIENCES CENTRE   (Canada)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e VA LONG BEACH HEALTHCARE SYSTEM   (United States)

^f UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CYSTEINE; FERRITIN; TRANSFERRIN; TYROSINE;

ADULT; ARTICLE; ENZYME ACTIVITY; FEMALE; FERRITIN BLOOD LEVEL; GENOTYPE; HEMOCHROMATOSIS; HOMOZYGOSITY; HOMOZYGOTE; HUMAN; HYPERFERRITINEMIA; IRON OVERLOAD; MAJOR CLINICAL STUDY; MALE; NORTH AMERICA; PRIORITY JOURNAL; SCREENING TEST; SEX DIFFERENCE;

ALANINE TRANSAMINASE; ASPARTATE AMINOTRANSFERASES; FEMALE; FERRITINS; HEMOCHROMATOSIS; HISTOCOMPATIBILITY ANTIGENS CLASS I; HOMOZYGOTE; HUMANS; IRON OVERLOAD; MALE; MEMBRANE PROTEINS; PROBABILITY;

EID: 84861576018     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.25538     Document Type: Article

References (18)

1. Adams PC, Barton JC. How I treat hemochromatosis. Blood 2010; 116: 317-325.
2. Adams PC, Reboussin DM, Barton JC, McLaren CE, Eckfeldt JH, McLaren GD, et al. Hemochromatosis and iron-overload screening in a racially diverse population. N Engl J Med 2005; 352: 1769-1778.
3. McLaren GD, McLaren CE, Adams PC, Barton JC, Reboussin DM, Gordeuk VR, et al. Clinical manifestations of hemochromatosis in HFE homozygotes identified by screening. Can J Gastroenterol 2008; 22: 923-930.
4. Adams PC, Barton JC, McLaren GD, Acton RT, Speechley M, McLaren CE, et al. Screening for iron overload: lessons from the HEIRS Study. Can J Gastroenterol 2009; 23: 771-774.
5. Adams PC, Passmore L, Chakrabarti S, Reboussin D, Acton R, Barton J, et al. Liver diseases in the Hemochromatosis and Iron Overload Screening Study. Clin Gastroenterol Hepatol 2006; 4: 918-923.
6. Beaton M, Adams PC. Assessment of silent liver fibrosis in hemochromatosis C282Y homozygotes with normal transaminase levels. Clin Gastroenterol Hepatol 2008; 6: 713-714.
7. Lin E, Adams PC. Biochemical liver profile in hemochromatosis. A survey of 100 patients. J Clin Gastroenterol 1991; 13: 316-320.
8. Powell EE, Ali A, Clouston AD, Dixon JL, Lincoln DJ, Purdie DM, et al. Steatosis is a cofactor in liver injury in hemochromatosis. Gastroenterology 2005; 129: 1937-1943.
9. Adams PC, Barton JC. A diagnostic approach to hyperferritinemia with a non-elevated transferrin saturation. J Hepatol 2011; 55: 453-458.
10. Hultcrantz R, Glaumann H, Lindberg G, Nilsson LH. Liver investigation in 149 asymptomatic patients with moderately elevated activities of serum aminotransferases. Scand J Gastroenterol 1986; 21: 109-113.
11. Friedman LS, Dienstag JL, Watkins E, Hinkle CA, Spiers JA, Rieder SV, et al. Evaluation of blood donors with elevated serum alanine aminotransferase levels. Ann Intern Med 1987; 107: 137-144.
12. Hay JE, Czaja AJ, Rakela J, Ludwig J. The nature of unexplained chronic aminotransferase elevations of a mild to moderate degree in asymptomatic patients. Hepatology 1989; 9: 193-197.
13. Daniel S, Ben-Menachem T, Vasudevan G, Ma CK, Blumenkehl M. Prospective evaluation of unexplained chronic liver transaminase abnormalities in asymptomatic and symptomatic patients. Am J Gastroenterol 1999; 94: 3010-3014.
14. Bhavnani M, Lloyd D, Bhattacharyya A, Marples J, Elton P, Worwood M. Screening for genetic haemochromatosis in blood samples with raised alanine aminotransferase. Gut 2000; 46: 707-710.
15. Meyer TJ, Van Kooten D, Prochazka AV. Pursuing mild elevations of liver enzyme values to exclude hemochromatosis. South Med J 1990; 83: 1277-1279.
16. Adams P, Zaccaro D, Moses G, Eckfeldt J, Leiendecker-Foster C, McLaren C, et al. Comparison of the unsaturated iron binding capacity with transferrin saturation as a screening test to detect C282Y homozygotes for hemochromatosis in 101, 168 participants in the HEIRS study. Clin Chem 2005; 51: 1048-1051.
17. Acton RT, Barton JC, Passmore LV, Adams PC, McLaren GD, Leiendecker-Foster C, et al. Accuracy of family history of hemochromatosis or iron overload: the hemochromatosis and iron overload screening study. Clin Gastroenterol Hepatol 2008; 6: 934-938.
18. Assy N, Adams PC. Predictive value of family history in diagnosis of hereditary hemochromatosis. Dig Dis Sci 1997; 42: 1312-1315.