Synthesis and SAR of selective small molecule neuropeptide y Y2 receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 12, 2012, Pages 3916-3920

  Mittapalli, Gopi Kumar ^a   Vellucci, Danielle ^a   Yang, Jun ^a   Toussaint, Marion ^a   Brothers, Shaun P ^b   Wahlestedt, Claes ^b   Roberts, Edward ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Antagonist; Carbamate; Neuropeptide Y Y2; Structure activity relationship; Thiourea

Indexed keywords

NEUROPEPTIDE Y RECEPTOR ANTAGONIST;

ARTICLE; DRUG POTENCY; DRUG SYNTHESIS; HIGH THROUGHPUT SCREENING; IC 50; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-OBESITY AGENTS; BIOLOGICAL ASSAY; CYCLIC AMP; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MICE; MOLECULAR WEIGHT; PIPERIDINES; RECEPTORS, NEUROPEPTIDE Y; STRUCTURE-ACTIVITY RELATIONSHIP; THIOUREA;

EID: 84861575066     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.04.107     Document Type: Article

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