Pre-steady state kinetic analysis of cyclobutyl derivatives of 2′-deoxyadenosine 5′-triphosphate as inhibitors of HIV-1 reverse transcriptase

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 12, 2012, Pages 4064-4067

  Kim, Jiae ^a   Wang, Ligong ^a,e   Li, Yongfeng ^b   Becnel, Kimberlynne D ^b   Frey, Kathleen M ^a   Garforth, Scott J ^c   Prasad, Vinayaka R ^c   Schinazi, Raymond F ^d   Liotta, Dennis C ^b   Anderson, Karen S ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b EMORY UNIVERSITY   (United States)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^d EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e GE HEALTHCARE   (United States)

Author keywords

Cyclobutyl adenosine analogs; HIV 1 RT; K65R mutant of RT; Pre steady state kinetics; Tenofovir

Indexed keywords

2' DEOXYADENOSINE 5' TRIPHOSPHATE; NUCLEOTIDYLTRANSFERASE INHIBITOR; PHOSPHATE; TENOFOVIR; TENOFOVIR DIPHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; BIOCHEMISTRY; CRYSTAL STRUCTURE; DRUG POTENCY; DRUG STRUCTURE; FOOD AND DRUG ADMINISTRATION; STEADY STATE;

ADENINE; ANTI-HIV AGENTS; CYCLOBUTANES; DEOXYADENINE NUCLEOTIDES; DNA PRIMERS; DRUG RESISTANCE, VIRAL; HIV REVERSE TRANSCRIPTASE; HIV-1; HUMANS; KINETICS; MUTATION; NUCLEIC ACID AMPLIFICATION TECHNIQUES; ORGANOPHOSPHONATES; REVERSE TRANSCRIPTASE INHIBITORS;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 84861574063     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.04.078     Document Type: Article

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