Identification of small-molecule inhibitors of the steroidogenic acute regulatory protein (STARD1) by structure-based design

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 12, 2012, Pages 4139-4143

  Akula, Nagaraju ^a   Midzak, Andrew ^a,b   Lecanu, Laurent ^a,b   Papadopoulos, Vassilios ^a,b  

^a MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

Cholesterol; Leydig cells; STAR; Steroiodogenesis

Indexed keywords

22 HYDROXYCHOLESTEROL; CYCLIC AMP; REGULATOR PROTEIN; SMALL MOLECULE TRANSPORT AGENT; STEROID; STEROIDOGENIC ACUTE REGULATORY PROTEIN 1; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DYNAMICS; HUMAN; MOLECULAR DOCKING; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN STRUCTURE; STEROIDOGENESIS;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CHOLESTEROL; CYCLIC AMP; DRUG DESIGN; HUMANS; KINETICS; LEYDIG CELLS; LIGANDS; MALE; MICE; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; PHOSPHOPROTEINS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SMALL MOLECULE LIBRARIES; STRUCTURAL HOMOLOGY, PROTEIN; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS;

EID: 84861572222     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.04.058     Document Type: Article

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