Exogenous expression of UHRF1 promotes proliferation and metastasis of breast cancer cells

Oncology Reports

Volumn 28, Issue 1, 2012, Pages 375-383

  Li, Xin Li ^a   Xu, Jiu Hong ^b   Nie, Ji Hua ^a   Fan, Sai Jun ^a  

^a MEDICAL COLLEGE OF SOOCHOW UNIVERSITY   (China)

^b SOOCHOW UNIVERSITY   (China)

Author keywords

Breast cancer; Cell proliferation; Human; Invasion; Migration; Oncogene; UHRF1

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CYCLIN D1; MASPIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN BAX; UBIQUITIN; UHRF1 PROTEIN; UNCLASSIFIED DRUG;

ANGIOGENESIS; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CELL CYCLE; CELL CYCLE G1 PHASE; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VIVO STUDY; METASTASIS; MICROVASCULATURE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RING FINGER MOTIF; WESTERN BLOTTING; XENOGRAFT;

ADENOCARCINOMA; ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BREAST NEOPLASMS; CCAAT-ENHANCER-BINDING PROTEINS; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CELL SURVIVAL; FEMALE; GENE EXPRESSION; HUMANS; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASM INVASIVENESS; NEOPLASM TRANSPLANTATION; NEOVASCULARIZATION, PATHOLOGIC; TUMOR BURDEN;

EID: 84861566595     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2012.1792     Document Type: Article

References (22)

1. Fidler IJ: The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. Nat Rev Cancer 3: 453-458, 2003.
2. Gwin K, Buell-Gutbrod R, Tretiakova M and Montag A: Epithelial-to- mesenchymal transition in metaplastic breast carcinomas with chondroid differentiation: expression of the E-cadherin repressor Snail. Appl Immunohistochem Mol Morphol 18: 526-531, 2010.
3. Daniele A, Zito AF, Giannelli G, Divella R, Asselti M, Mazzocca A, Paradiso A and Quaranta M: Expression of metalloproteinases MMP-2 and MMP-9 in sentinel lymph node and serum of patients with metastatic and non-metastatic breast cancer. Anticancer Res 30: 3521-3527, 2010.
4. Li C, Li R, Song H, Wang D, Feng T, Yu X, Zhao Y, Liu J, Yu X, Wang Y and Geng J: Significance of AEG-1 expression in correlation with VEGF, microvessel density and clinicopathological characteristics in triple-negative breast cancer. J Surg Oncol 103: 184-192, 2011.
5. Esteva FJ, Guo H, Zhang S, Santa-Maria C, Stone S, Lanchbury JS, Sahin AA, Hortobagyi GN and Yu D: PTEN, PIK3CA, p-AKT, and p-p70S6K status: association with trastuzumab response and survival in patients with HER2-positive metastatic breast cancer. Am J Pathol 177: 1647-1656, 2010.
6. McClusky DR, Chu Q, Yu H, Debenedetti A, Johnson LW, Meschonat C, Turnage R, McDonald JC, Abreo F and Li BD: A prospective trial on initiation factor 4E (eIF4E) overexpression and cancer recurrence in node-positive breast cancer. Ann Surg 242: 584-592, 2005. (Pubitemid 41428654)
7. Hopfner R, Mousli M, Jeltsch JM, Voulgaris A, Lutz Y, Marin C, Bellocq JP, Oudet P and Bronner C: ICBP90, a novel human CCAAT binding protein, involved in the regulation of topoisomerase IIalpha expression. Cancer Res 60: 121-128, 2000. (Pubitemid 30058741)
8. Hopfner R, Mousli M, Oudet P and Bronner C: Overexpression of ICBP90, a novel CCAAT-binding protein, overcomes cell contact inhibition by forcing topoisomerase II alpha expression. Anticancer Res 22: 3165-3170, 2002. (Pubitemid 36070088)
9. Bonapace IM, Latella L, Papait R, Nicassio F, Sacco A, Muto M, Crescenzi M and Di Fiore PP: Np95 is regulated by E1A during mitotic reactivation of terminally differentiated cells and is essential for S phase entry. J Cell Biol 157: 909-914, 2002. (Pubitemid 34839765)
10. Citterio E, Papait R, Nicassio F, Vecchi M, Gomiero P, Mantovani R, Di Fiore PP and Bonapace IM: Np95 is a histone-binding protein endowed with ubiquitin ligase activity. Mol Cell Biol 24: 2526-2535, 2004. (Pubitemid 38326006)
11. Mousli M, Hopfner R, Abbady AQ, Monté D, Jeanblanc M, Oudet P, Louis B and Bronner C: ICBP90 belongs to a new family of proteins with an expression that is deregulated in cancer cells. Br J Cancer 89: 120-127, 2003. (Pubitemid 36897947)
12. Li XL, Zhu W, Zhu R and Fan SJ: Effect of human UHRF1 on growth of breast cancer BT-549 cells. Suzhou University J Med Sci 28: 345-348, 2008 (In Chinese).
13. Li XL, Meng QH and Fan SJ: Adenovirus-mediated expression of UHRF1 reduces the radiosensitivity of cervical cancer HeLa cells to gamma-irradiation. Acta Pharmacol Sin 30: 458-466, 2009.
14. Li X, Meng Q, Rosen EM and Fan S: UHRF1 confers radioresistance to human breast cancer cells. Int J Radiat Biol 87: 263-273, 2011.
15. Yang F, Li Z, Deng H, Yang H, Yan F, Qian Z, Chen L, Wei Y and Zhao X: Efficient inhibition of ovarian cancer growth and prolonged survival by transfection with a novel pro-apoptotic gene, hPNAS-4, in a mouse model. In vivo and in vitro results. Oncology 75: 137-144, 2008.
16. Walensky LD: BCL-2 in the crosshairs: tipping the balance of life and death. Cell Death Differ 13: 1339-1350, 2006.
17. Thomadaki H and Scorilas A: BCL-2 family of apoptosis-related genes: functions and clinical implications in cancer. Crit Rev Clin Lab Sci 43: 1-7, 2006.
18. Kim R: Recent advances in understanding the cell death pathways activated by anticancer therapy. Cancer 103: 1551-1560, 2005.
19. Ravenhill L, Wagstaff L, Edwards DR, Ellis V and Bass R: G-helix of maspin mediates effects on cell migration and adhesion. J Biol Chem 285: 36285-36292, 2010.
20. Sharma G, Mirza S, Parshad R, Srivastava A, Gupta SD, Pandya P and Ralhan R: Clinical significance of Maspin promoter methylation and loss of its protein expression in invasive ductal breast carcinoma: correlation with VEGF-A and MTA1 expression. Tumour Biol 32: 23-32, 2011.
21. Fabi A, Metro G, Di Benedetto A, Nisticò C, Vici P, Melucci E, Antoniani B, Perracchio L, Sperduti I, Milella M, Cognetti F and Mottolese M: Clinical significance of PTEN and p-Akt co-expression in HER2-positive metastatic breast cancer patients treated with trastuzumab-based therapies. Oncology 78: 141-149, 2010.
22. Hong TM, Yang PC, Peck K, Chen JJ, Yang SC, Chen YC and Wu CW: Profiling the downstream genes of tumor suppressor PTEN in lung cancer cells by complementary DNA microarray. AM J Respir Cell Mol Biol 23: 355-363, 2000.