Targeting melanoma metastasis and immunosuppression with a new mode of melanoma inhibitory activity (MIA) protein inhibition

PLoS ONE

Volumn 7, Issue 5, 2012, Pages

  Schmidt, Jennifer ^a   Riechers, Alexander ^a   Stoll, Raphael ^b   Amann, Thomas ^c   Fink, Florian ^a   Spruss, Thilo ^a   Gronwald, Wolfram ^a   König, Burkhard ^a   Hellerbrand, Claus ^c   Bosserhoff, Anja Katrin ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

^b RUHR UNIVERSITY BOCHUM   (Germany)

^c UNIVERSITY HOSPITAL REGENSBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; AR71 PEPTIDE; CASPASE 3; MELANOMA INHIBITORY ACTIVITY PROTEIN; TUMOR MARKER; UNCLASSIFIED DRUG; MIA PROTEIN, HUMAN; OLIGOPEPTIDE; SCLEROPROTEIN; TUMOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CD3+ T LYMPHOCYTE; CONTROLLED STUDY; DIMERIZATION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IN VITRO STUDY; IN VIVO STUDY; LIVER METASTASIS; MELANOMA CELL; MELANOMA METASTASIS; METASTASIS INHIBITION; MIGRATION INHIBITION; MOUSE; MUTAGENESIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; AMINO ACID SEQUENCE; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; EXPERIMENTAL MELANOMA; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; MELANOMA; METABOLISM; METASTASIS; METHODOLOGY; MOLECULAR GENETICS; MOLECULARLY TARGETED THERAPY; PATHOLOGY; PROTEIN MULTIMERIZATION; PROTEIN QUATERNARY STRUCTURE; TUMOR CELL LINE;

AMINO ACID SEQUENCE; ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; EXTRACELLULAR MATRIX PROTEINS; HUMANS; IMMUNE TOLERANCE; MELANOMA; MELANOMA, EXPERIMENTAL; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR TARGETED THERAPY; NEOPLASM METASTASIS; NEOPLASM PROTEINS; OLIGOPEPTIDES; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY;

EID: 84861553473     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0037941     Document Type: Article

References (29)

1. Blesch A, Bosserhoff AK, Apfel R, Behl C, Hessdoerfer B, et al. (1994) Cloning of a novel malignant melanoma-derived growth-regulatory protein, MIA. Cancer Res 54: 5695-5701.
2. Bosserhoff AK, Hein R, Bogdahn U, Buettner R, (1996) Structure and promoter analysis of the gene encoding the human melanoma-inhibiting protein MIA. J Biol Chem 271: 490-495.
3. Stahlecker J, Gauger A, Bosserhoff A, Buttner R, Ring J, et al. (2000) MIA as a reliable tumor marker in the serum of patients with malignant melanoma. Anticancer Res 20: 5041-5044.
4. Bosserhoff AK, Buettner R, (2002) Expression, function and clinical relevance of MIA (melanoma inhibitory activity). Histol Histopathol 17: 289-300.
5. Schmidt J, Friebel K, Schonherr R, Coppolino MG, Bosserhoff AK, (2010) Migration-associated secretion of melanoma inhibitory activity at the cell rear is supported by KCa3.1 potassium channels. Cell Res 20: 1224-1238.
6. Bosserhoff AK, Stoll R, Sleeman JP, Bataille F, Buettner R, et al. (2003) Active detachment involves inhibition of cell-matrix contacts of malignant melanoma cells by secretion of melanoma inhibitory activity. Lab Invest 83: 1583-1594.
7. Jachimczak P, Apfel R, Bosserhoff AK, Fabel K, Hau P, et al. (2005) Inhibition of immunosuppressive effects of melanoma-inhibiting activity (MIA) by antisense techniques. Int J Cancer 113: 88-92.
8. Stoll R, Renner C, Zweckstetter M, Bruggert M, Ambrosius D, et al. (2001) The extracellular human melanoma inhibitory activity (MIA) protein adopts an SH3 domain-like fold. EMBO J 20: 340-349.
9. Lougheed JC, Holton JM, Alber T, Bazan JF, Handel TM, (2001) Structure of melanoma inhibitory activity protein, a member of a recently identified family of secreted proteins. Proc Natl Acad Sci U S A 98: 5515-5520.
10. Dominguez C, Boelens R, Bonvin AM, (2003) HADDOCK: a protein-protein docking approach based on biochemical or biophysical information. J Am Chem Soc 125: 1731-1737.
11. Stoll R, Lodermeyer S, Bosserhoff AK, (2006) Detailed analysis of MIA protein by mutagenesis. Biol Chem 387: 1601-1606.
12. Stoll R, Bosserhoff A, (2008) Extracellular SH3 domain containing proteins - features of a new protein family. Curr Protein Pept Sci 9: 221-226.
13. Riechers A, Schmidt J, Konig B, Bosserhoff AK, (2009) Heterogeneous transition metal-based fluorescence polarization (HTFP) assay for probing protein interactions. Biotechniques 47: 837-844.
14. Bosserhoff AK, Echtenacher B, Hein R, Buettner R, (2001) Functional role of melanoma inhibitory activity in regulating invasion and metastasis of malignant melanoma cells in vivo. Melanoma Res 11: 417-421.
15. Guba M, Bosserhoff AK, Steinbauer M, Abels C, Anthuber M, et al. (2000) Overexpression of melanoma inhibitory activity (MIA) enhances extravasation and metastasis of A-mel 3 melanoma cells in vivo. Br J Cancer 83: 1216-1222.
16. Carrascal MT, Mendoza L, Valcarcel M, Salado C, Egilegor E, et al. (2003) Interleukin-18 binding protein reduces b16 melanoma hepatic metastasis by neutralizing adhesiveness and growth factors of sinusoidal endothelium. Cancer Res 63: 491-497.
17. Moser M, Bosserhoff AK, Hunziker EB, Sandell L, Fassler R, et al. (2002) Ultrastructural cartilage abnormalities in MIA/CD-RAP-deficient mice. Mol Cell Biol 22: 1438-1445.
18. Wolf K, Wu YI, Liu Y, Geiger J, Tam E, et al. (2007) Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion. Nat Cell Biol 9: 893-904.
19. Baumann F, Leukel P, Doerfelt A, Beier CP, Dettmer K, et al. (2009) Lactate promotes glioma migration by TGF-beta2-dependent regulation of matrix metalloproteinase-2. Neuro Oncol 11: 368-380.
20. Kuphal S, Wallner S, Schimanski CC, Bataille F, Hofer P, et al. (2006) Expression of Hugl-1 is strongly reduced in malignant melanoma. Oncogene 25: 103-110.
21. Massoumi R, Kuphal S, Hellerbrand C, Haas B, Wild P, et al. (2009) Down-regulation of CYLD expression by Snail promotes tumor progression in malignant melanoma. J Exp Med 206: 221-232.
22. Tatzel J, Poser I, Schroeder J, Bosserhoff AK, (2005) Inhibition of melanoma inhibitory activity (MIA) expression in melanoma cells leads to molecular and phenotypic changes. Pigment Cell Res 18: 92-101.
23. Davis DG, Bax A, (1985) Simplification of H1Nmr Spectra by Selective Excitation of Experimental Subspectra. J Am Chem Soc 107: 7197-7198.
24. Shaka AJ, Lee C, Pines A, (1988) Iterative Schemes for Bilinear Operators Application to Spin Decoupling. Journal of Magnetic Resonance 77: 274-293.
25. Mori S, Abeygunawardana C, Johnson MO, van Zijl PC, (1995) Improved sensitivity of HSQC spectra of exchanging protons at short interscan delays using a new fast HSQC (FHSQC) detection scheme that avoids water saturation. J Magn Reson B 108: 94-98.
26. Delaglio F, Grzesiek S, Vuister GW, Zhu G, Pfeifer J, et al. (1995) NMRPipe: a multidimensional spectral processing system based on UNIX pipes. J Biomol NMR 6: 277-293.
27. Delano WL, (2002) The PyMol Molecular Graphics System.
28. Schwarten M, Berghaus C, Heumann R, Stoll R, (2007) Sequence-specific 1H, 13C, and 15N backbone assignment of the activated 21 kDa GTPase rRheb. Biomol NMR Assign 1: 105-108.
29. Schmidt J, Bosserhoff AK, (2009) Processing of MIA protein during melanoma cell migration. Int J Cancer 125: 1587-1594.