Excision of Trpv6 gene leads to severe defects in epididymal Ca 2+ absorption and male fertility much like single D541A pore mutation

Journal of Biological Chemistry

Volumn 287, Issue 22, 2012, Pages 17930-17941

  Weissgerber, Petra ^a   Kriebs, Ulrich ^a   Tsvilovskyy, Volodymyr ^a,d   Olausson, Jenny ^a   Kretz, Oliver ^c   Stoerger, Christof ^a   Mannebach, Stefanie ^a   Wissenbach, Ulrich ^a   Vennekens, Rudi ^a   Middendorff, Ralf ^b   Flockerzi, Veit ^a   Freichel, Marc ^a,d  

^a SAARLAND UNIVERSITY   (Germany)

^b JUSTUS LIEBIG UNIVERSITY   (Germany)

^c UNIVERSITY OF FREIBURG   (Germany)

^d UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTATE RESIDUE; C TERMINUS; CATION CHANNELS; CHANNEL ACTIVITY; CYTOSOLIC; EPITHELIAL CELLS; IN-VIVO; MALE FERTILITY; MEMBRANE ANCHORING; PORE MUTATION; RESIDUAL ACTIVITY; RESIDUAL FUNCTIONS; SPERM MOTILITY; TRANS-MEMBRANE DOMAINS;

ACTIVATION ANALYSIS; AMINO ACIDS; CELL MEMBRANES; DEFECTS; GENES; MAMMALS; PLANTS (BOTANY); PROTEINS;

CALCIUM;

ALANINE; ASPARTIC ACID; CALCIUM ION; VANILLOID RECEPTOR 6;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING SITE; CALCIUM ABSORPTION; CALCIUM TRANSPORT; CELL MEMBRANE; CHANNEL GATING; CONTROLLED STUDY; CYTOSOL; EPIDIDYMIS; EPITHELIUM CELL; EXON; FERTILIZATION IN VITRO; GENE DELETION; HOMOZYGOSITY; MALE; MALE FERTILITY; MALE INFERTILITY; MEMBRANE BINDING; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SPERMATOZOON MOTILITY; TRPV6 GENE;

ANIMALS; BASE SEQUENCE; CALCIUM; CALCIUM CHANNELS; DNA PRIMERS; EPIDIDYMIS; FEMALE; FERTILITY; GENE DELETION; MALE; MICE; MICE, KNOCKOUT; MUTATION; SPERM MOTILITY; TRPV CATION CHANNELS;

MUS;

EID: 84861537515     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.328286     Document Type: Article

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