Drug release from matrix systems: Analysis by finite element methods

Heat and Mass Transfer/Waerme- und Stoffuebertragung

Volumn 48, Issue 3, 2012, Pages 519-528

  Galdi, Ivan ^a   Lamberti, Gaetano ^a  

^a UNIVERSITY OF SALERNO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEX GEOMETRIES; DRUG DELIVERY SYSTEM; DRUG RELEASE; MASS BALANCE; MATRIX SYSTEMS; REALISTIC SYSTEMS; SIMPLE GEOMETRIES; SOLID SYSTEMS; VARIABLE DIFFUSIVITY;

DRUG DELIVERY;

FINITE ELEMENT METHOD;

EID: 84861528134     PISSN: 09477411     EISSN: 14321181     Source Type: Journal    
DOI: 10.1007/s00231-011-0900-y     Document Type: Article

References (20)

1. Siepmann J, Siepmann F (2008) Mathematical modeling of drug delivery. Int J Pharm 364:328-343
2. Higuchi T (1961) Rate of release of medicaments from ointment bases containing drugs in suspensions. J Pharm Sci 50:874-875
3. Crank J (1975) The mathematic of diffusion, 2nd edn. The Clarendon Press, Oxford
4. Peppas NA, Sahlin JJ (1989) A simple equation for the description of solute release. III. Coupling of diffusion and relaxation. Int J Pharm 57:169-172 (Pubitemid 20011841)
5. Grassi M, Grassi G (2005) Mathematical modelling and controlled drug delivery: matrix systems. Curr Drug Deliv 2:97-116 (Pubitemid 40590925)
6. Siepmann J, Ainaoui A, Vergnaud JM, Bodmeier R (1998) Calculation of the dimensions of drug-polymer devices based on diffusion parameters. J Pharm Sci 87(7):827-832 (Pubitemid 28319412)
7. Carslaw HS, Jaeger JC (1959) Conduction of heat in solids, 2nd edn. The Clarendon Press, Oxford
8. Zhou Y, Wu XY (1997) Finite element analysis of diffusional drug release from complex matrix systems. I. Complex geometries and composite structures. J Control Release 49:277-288 (Pubitemid 28020280)
9. Wu XY, Zhou Y (1998) Finite element analysis of diffusional drug release from complex matrix systems. II. Factors influencing release kinetics. J Control Release 51:57-71 (Pubitemid 28064645)
10. Siepmann J, Kranz H, Bodmeier R, Peppas NA (1999) HPMCmatrices for controlled drug delivery: a new model combining diffusion, swelling, and dissolution mechanism and predicting the release kinetics. Pharm Res 16(11):1748-1756 (Pubitemid 29530409)
11. Siepmann J, Peppas NA (2000) Hydrophilic matrices for controlled drug delivery: an improved mathematical model to predict the resulting drug release kinetics (the ''sequential layer'' model). Pharm Res 17:1290-1298
12. Grassi M, Colombo I, Lapasin R (2000) Drug release from an ensemble of swellable crosslinked polymer particles. J Control Release 68:97-113 (Pubitemid 30407065)
13. Kiil S, Johansen Dam-K (2003) Controlled drug delivery from swellable hydroxypropylmethylcellulose matrices: model-based analysis of observed radial front movements. J Control Release 90:1-21 (Pubitemid 36588875)
14. Goepferich A, Langer R (1995) Modeling monomer release from bioerodible polymers. J Control Release 33:55-69
15. Goepferich A, Langer R (1995) Modeling of polymer erosion in three dimensions: rotationally symmetric devices. AIChE J 41:2292-2299
16. Lapidus L, Pinder GF (1982) Numerical Solution of partial differential equation in science and engineering. Wiley, New York
17. COMSOL Multiphysics user's guide (2007) -COPYRIGHT 1994-2007 (by COMSOL AB)
18. Barba AA, D'Amore M, Chirico S, Lamberti G, Titomanlio G (2009) A general code to predict the drug release kinetics from different shaped matrices. Eur J Pharm Sci 36:359-368
19. Horcajada P, Ramila A, Perez-Pariente J, Vallet-Regì M (2004) Influence of pore size of MCM-41 matrices on drug delivery rate. Micropor Mesopor Mat 68:105-109 (Pubitemid 38265756)
20. Grassi M, Lapasin R, Coviello T, Matricardi P, Di Meo C, Alhaique F (2009) Scleroglucan/borax/drug hydrogels: structure characterization by means of rheological and diffusion experiments. Carbohyd Polym 78(3):377-383