Anatomical and pathological findings in hearts from fetuses and infants with cardiac manifestations of neonatal lupus

Rheumatology (United Kingdom)

Volumn 51, Issue 6, 2012, Pages 1086-1092

  Llanos, Carolina ^a,b   Friedman, Deborah M ^c   Saxena, Amit ^a   Izmirly, Peter M ^a   Tseng, Chung E ^a   Dische, Renata ^d   Abellar, Rosanna G ^e   Halushka, Marc ^f   Clancy, Robert M ^a   Buyon, Jill P ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

^c NEW YORK MEDICAL COLLEGE   (United States)

^d New York Presbyterian Hospital Columbia University Medical Center   (United States)

^e NewYork Presbyterian Hospital   (United States)

^f DEPARTMENT OF PATHOLOGY   (United States)

Author keywords

Anti SSA Ro antibodies; Autoimmune congenital heart block; Neonatal lupus

Indexed keywords

LA ANTIBODY; RO ANTIBODY;

ARTICLE; AUTOPSY; CALCIFICATION; CARDIOMYOPATHY; CLINICAL ARTICLE; DEATH; ECHOCARDIOGRAPHY; ENDOCARDIAL FIBROELASTOSIS; FETUS; FETUS DEATH; FETUS HEART; HEART ATRIOVENTRICULAR NODE; HEART ATRIUM SEPTUM; HEART BLOCK; HEART CALCIFICATION; HEART DISEASE; HEART MUSCLE CONDUCTION DISTURBANCE; HEART MUSCLE FIBROSIS; HEART PAPILLARY MUSCLE; HEART RHYTHM; HIS BUNDLE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; INFANT; NEONATAL LUPUS; NEWBORN DEATH; NEWBORN DISEASE; PATHOGENESIS; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SECOND TRIMESTER PREGNANCY; SINUS NODE; THIRD TRIMESTER PREGNANCY; VALVULAR HEART DISEASE;

ANTIBODIES, ANTINUCLEAR; BIOLOGICAL MARKERS; CALCINOSIS; FEMALE; FETAL DEATH; FETAL DISEASES; FIBROSIS; HEART BLOCK; HEART CONDUCTION SYSTEM; HUMANS; INFANT; INFANT, NEWBORN; LUPUS ERYTHEMATOSUS, SYSTEMIC; MYOCARDIUM; PREGNANCY; REGISTRIES; RETROSPECTIVE STUDIES; RISK FACTORS;

EID: 84861473083     PISSN: 14620324     EISSN: 14620332     Source Type: Journal    
DOI: 10.1093/rheumatology/ker515     Document Type: Article

References (30)

1. Brucato A., Frassi M., Franceschini F, et al. Risk of congenital complete heart block in newborns of mothers with anti-Ro/SSA antibodies detected by counterimmunoelectrophoresis: a prospective study of 100 women. Arthritis Rheum 2001;44:1832-5.
2. Friedman D.M., Kim M.Y., Copel J.A, et al. Utility of cardiac monitoring in fetuses at risk for congenital heart block: the PR Interval and Dexamethasone Evaluation (PRIDE) prospective study. Circulation 2008; 117:485-93.
3. Buyon JP, Clancy RM, Friedman DM. Cardiac manifestations of neonatal lupus erythematosus: guidelines to management, integrating clues from the bench and bedside. Nat Clin Pract Rheumatol 2009;5:139-48.
4. Buyon JP, Hiebert R, Copel J, et al. Autoimmuneassociated congenital heart block: demographics, mortality, morbidity and recurrence rates obtained from a national neonatal lupus registry. J Am Coll Cardiol 1998; 31:1658-66.
5. Izmirly PM, Saxena A, Kim MY, et al. Maternal and fetal factors associated with mortality and morbidity in a multi-racial/ethnic registry of anti-SSA/Ro-associated cardiac neonatal lupus. Circulation 2011;124:1927-35.
6. Llanos C, Izmirly PM, Katholi M, et al. Recurrence rates of cardiac manifestations associated with neonatal lupus and maternal/fetal risk factors. Arthritis Rheum 2009;60: 3091-7.
7. Friedman DM, Llanos C, Izmirly PM, et al. Evaluation of fetuses in a study of intravenous immunoglobulin as preventive therapy for congenital heart block: results of a multicenter, prospective, open-label clinical trial. Arthritis Rheum 2010;62:1138-46.
8. Pisoni CN, Brucato A, Ruffatti A, et al. Failure of intravenous immunoglobulin to prevent congenital heart block: findings of a multicenter, prospective, observational study. Arthritis Rheum 2010;62:1147-52.
9. Izmirly PM, Kim MY, Llanos C, et al. Evaluation of the risk of anti-SSA/Ro-SSB/La antibody-associated cardiac manifestations of neonatal lupus in fetuses of mothers with systemic lupus erythematosus exposed to hydroxychloroquine. Ann Rheum Dis 2010;69:1827-30.
10. Clancy RM, Buyon JP, Ikeda K, et al. Maternal antibody responses to the 52-kd SSA/RO p200 peptide and the development of fetal conduction defects. Arthritis Rheum 2005;52:3079-86.
11. Salomonsson S, Dorner T, Theander E, et al. A serologic marker for fetal risk of congenital heart block. Arthritis Rheum 2002;46:1233-41.
12. Clancy RM, Neufing PJ, Zheng P, et al. Impaired clearance of apoptotic cardiocytes is linked to anti-SSA/Ro and -SSB/La antibodies in the pathogenesis of congenital heart block. J Clin Invest 2006;116:2413-22.
13. Miranda-Carus ME, Askanase AD, Clancy RM, et al. Anti-SSA/Ro and anti-SSB/La autoantibodies bind the surface of apoptotic fetal cardiocytes and promote secretion of TNF-alpha by macrophages. J Immunol 2000;165:5345-51.
14. Clancy RM, Askanase AD, Kapur RP, et al. Transdifferentiation of cardiac fibroblasts, a fetal factor in anti-SSA/Ro-SSB/La antibody-mediated congenital heart block. J Immunol 2002;169:2156-63.
15. Nield LE, Silverman ED, Taylor GP, et al. Maternal anti-Ro and anti-La antibody-associated endocardial fibroelastosis. Circulation 2002;105:843-8.
16. Moak JP, Barron KS, Hougen TJ, et al. Congenital heart block: development of late-onset cardiomyopathy, a previously underappreciated sequela. J Am Coll Cardiol 2001; 37:238-42.
17. Cuneo BF, Strasburger JF, Niksch A, et al. An expanded phenotype of maternal SSA/SSB antibody-associated fetal cardiac disease. J Matern Fetal Neonatal Med 2009; 22:233-8.
18. Qu Y, Baroudi G, Yue Y, et al. Novel molecular mechanism involving alpha1D (Cav1.3) L-type calcium channel in autoimmune-associated sinus bradycardia. Circulation 2005;111:3034-41.
19. Mangoni ME, Nargeot J. Genesis and regulation of the heart automaticity. Physiol Rev 2008;88:919-82.
20. Cuneo BF, Fruitman D, Benson DW, et al. Spontaneous rupture of atrioventricular valve tensor apparatus as late manifestation of anti-Ro/SSA antibody-mediated cardiac disease. Am J Cardiol 2011;107:761-6.
21. Llanos C, Chan EK, Li S, et al. Antibody reactivity to alpha-enolase in mothers of children with congenital heart block. J Rheumatol 2009;36:565-9.
22. Clancy RM, Kapur RP, Molad Y, et al. Immunohistologic evidence supports apoptosis, IgG deposition, and novel macrophage/fibroblast crosstalk in the pathologic cascade leading to congenital heart block. Arthritis Rheum 2004;50:173-82.
23. Meckler KA, Kapur RP. Congenital heart block and associated cardiac pathology in neonatal lupus syndrome. Pediatr Dev Pathol 1998;1:136-42.
24. Rivera TL, Izmirly PM, Birnbaum BK, et al. Disease progression in mothers of children enrolled in the Research Registry for Neonatal Lupus. Ann Rheum Dis 2009;68: 828-35.
25. Nield LE, Silverman ED, Smallhorn JF, et al. Endocardial fibroelastosis associated with maternal anti-Ro and anti-La antibodies in the absence of atrioventricular block. J Am Coll Cardiol 2002;40:796-802.
26. Guettrot-Imbert G, Cohen L, Fermont L, et al. A new presentation of neonatal lupus: 5 cases of isolated mild endocardial fibroelastosis associated with maternal anti-SSA/Ro and anti-SSB/La antibodies. J Rheumatol 2010;38:378-86.
27. Bharati S, Swerdlow MA, Vitullo D, et al. Neonatal lupus with congenital atrioventricular block and myocarditis. Pacing Clin Electrophysiol 1987;10:1058-70.
28. Litsey SE, Noonan JA, O'Connor WN, et al. Maternal connective tissue disease and congenital heart block. Demonstration of immunoglobulin in cardiac tissue. N Engl J Med 1985;312:98-100.
29. Lee LA, Coulter S, Erner S, et al. Cardiac immunoglobulin deposition in congenital heart block associated with maternal anti-Ro autoantibodies. Am J Med 1987;83: 793-6.
30. Chameides L, Truex RC, Vetter V, et al. Association of maternal systemic lupus erythematosus with congenital complete heart block. N Engl J Med 1977;297:1204-7.