Egr1: A novel target for ameliorating acute allograft rejection in an experimental lung transplant model

European Journal of Cardio-thoracic Surgery

Volumn 41, Issue 3, 2012, Pages 669-675

  Waki, Naohisa ^a   Yamane, Masaomi ^a   Yamamoto, Sumiharu ^a   Okazaki, Mikio ^a   Sugimoto, Seiichiro ^a   Matsukawa, Akihiro ^a   Oto, Takahiro Oto ^a   Miyoshi, Shinichiro ^a  

^a OKAYAMA UNIVERSITY   (Japan)

Author keywords

Acute rejection; Egr 1; Inflammatory cytokines; Lung transplantation

Indexed keywords

EARLY GROWTH RESPONSE FACTOR 1; INTERLEUKIN 1BETA; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; PLASMINOGEN ACTIVATOR INHIBITOR 1; EGR1 PROTEIN, MOUSE;

ACUTE GRAFT REJECTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; DISEASE SEVERITY; GENE DELETION; GENE EXPRESSION; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; LUNG GRAFT REJECTION; LUNG TRANSPLANTATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION; WILD TYPE; ACUTE DISEASE; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; CD4 CD8 RATIO; DISEASE MODEL; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GENETICS; GRAFT REJECTION; IMMUNOLOGY; METABOLISM; METHODOLOGY; MOUSE MUTANT; PATHOLOGY; PHYSIOLOGY;

ACUTE DISEASE; ANIMALS; CD4-CD8 RATIO; DISEASE MODELS, ANIMAL; EARLY GROWTH RESPONSE PROTEIN 1; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GRAFT REJECTION; LUNG TRANSPLANTATION; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 84861433492     PISSN: 10107940     EISSN: 1873734X     Source Type: Journal    
DOI: 10.1093/ejcts/ezr030     Document Type: Article

References (24)

1. Christie JD, Edwards LB, Kucheryavaya AY, Aurora P, Dobbels F, Kirk R et al. The Registry of the International Society for Heart and Lung Transplantation: twenty-seventh official adult lung and heart-lung transplant report-2010. J Heart Lung Transplant 2010;29:1104-18.
2. DeMeo D, Ginns L. Lung transplantation at the turn of the century. Annu Rev Med 2001;52:185-201.
3. Bando K, Paradis I, Similo S, Konishi H, Komatsu K, Zullo T et al. Obliterative bronchiolitis after lung and heart-lung transplantation. An analysis of risk factors and management. J Thorac Cardiovasc Surg 1995; 110:4-13; discussion 13-14.
4. Yousem S, Dauber J, Keenan R, Paradis I, Zeevi A, Griffith B. Does histologic acute rejection in lung allografts predict the development of bronchiolitis obliterans? Transplantation 1991;52:306-9.
5. Reichenspurner H, Girgis R, Robbins R, Yun K, Nitschke M, Berry G et al. Stanford experience with obliterative bronchiolitis after lung and heart- lung transplantation. Ann Thorac Surg 1996;62:1467-72; discussion 1472-1463.
6. Sharples L, Tamm M, McNeil K, Higenbottam T, Stewart S, Wallwork J. Development of bronchiolitis obliterans syndrome in recipients of heart-lung transplantation-early risk factors. Transplantation 1996;61: 560-6.
7. Chamberlain D, Maurer J, Chaparro C, Idolor L. Evaluation of transbronchial lung biopsy specimens in the diagnosis of bronchiolitis obliterans after lung transplantation. J Heart Lung Transplant 1994;13:963-71.
8. Estenne M, Hertz M. Bronchiolitis obliterans after human lung transplantation. Am J Respir Crit Care Med 2002;166:440-4.
9. Boehler A, Kesten S, Weder W, Speich R. Bronchiolitis obliterans after lung transplantation: a review. Chest 1998;114:1411-26.
10. Gashler A, Sukhatme V. Early growth response protein 1 (Egr-1): prototype of a zinc-finger family of transcription factors. Prog Nucleic Acid Res Mol Biol 1995;50:191-224.
11. Yan S, Fujita T, Lu J, Okada K, Shan Zou Y, Mackman N et al. Egr-1, a master switch coordinating upregulation of divergent gene families underlying ischemic stress. Nat Med 2000;6:1355-61.
12. Yan S, Lu J, Xu L, Zou Y, Tongers J, Kisiel W et al. Pulmonary expression of early growth response-1: biphasic time course and effect of oxygen concentration. J Appl Physiol 2000;88:2303-9.
13. Copland I, Kavanagh B, Engelberts D, McKerlie C, Belik J, Post M. Early changes in lung gene expression due to high tidal volume. Am J Respir Crit Care Med 2003;168:1051-9.
14. Okazaki M, Krupnick A, Kornfeld C, Lai J, Ritter J, Richardson S et al. A mouse model of orthotopic vascularized aerated lung transplantation. Am J Transplant 2007;7:1672-9.
15. Diggle P, Liang K-Y, Zeger SL. Analysis of Longitudinal Data. Oxford: Clarendon Press, 1994.
16. Autieri M, Kelemen S, Gaughan J, Eisen H. Early growth responsive gene (Egr)-1 expression correlates with cardiac allograft rejection. Transplantation 2004;78:107-11.
17. Harada H, Lama V, Badri L, Ohtsuka T, Petrovic-Djergovic D, Liao H et al. Early growth response gene-1 promotes airway allograft rejection. Am J Physiol Lung Cell Mol Physiol 2007;293:L124-30.
18. Oishi H, Okada Y, Kikuchi T, Hoshikawa Y, Sado T, Noda M et al. Transbronchial human interleukin-10 gene transfer reduces acute inflammation associated with allograft rejection and intragraft interleukin-2 and tumor necrosis factor-alpha gene expression in a rat model of lung transplantation. J Heart Lung Transplant 2010;29:360-7.
19. Okada M, Fujita T, Sakaguchi T, Olson K, Collins T, Stern D et al. Extinguishing Egr-1-dependent inflammatory and thrombotic cascades after lung transplantation. FASEB J 2001;15:2757-9.
20. Boros P, Bromberg J. New cellular and molecular immune pathways in ischemia/reperfusion injury. Am J Transplant 2006;6:652-8.
21. Whitehead B, Stoehr C, Finkle C, Patterson G, Theodore J, Clayberger C et al. Analysis of bronchoalveolar lavage from human lung transplant recipients by flow cytometry. Respir Med 1995;89:27-34.
22. Crim C, Keller C, Dunphy C, Maluf H, Ohar J. Flow cytometric analysis of lung lymphocytes in lung transplant recipients. Am J Respir Crit Care Med 1996;153:1041-6.
23. Clelland C, Higenbottam T, Stewart S, Otulana B, Wreghitt T, Gray J et al. Bronchoalveolar lavage and transbronchial lung biopsy during acute rejection and infection in heart-lung transplant patients. Studies of cell counts, lymphocyte phenotypes, and expression of HLA-DR and interleukin-2 receptor. Am Rev Respir Dis 1993;147:1386-92.
24. Gelman A, Okazaki M, Lai J, Kornfeld C, Kreisel F, Richardson S et al. CD4+ T lymphocytes are not necessary for the acute rejection of vascularized mouse lung transplants. J Immunol 2008;180:4754-62.