Biochemical parameters of pregnant rats and their offspring exposed to different doses of inorganic mercury in drinking water

Food and Chemical Toxicology

Volumn 50, Issue 7, 2012, Pages 2382-2387

  Oliveira, Cláudia S ^a   Oliveira, Vitor A ^a   Ineu, Rafael P ^a   Moraes Silva, Lucélia ^a   Pereira, Maria E ^a  

^a FEDERAL UNIVERSITY OF SANTA MARIA   (Brazil)

Author keywords

Fetuses; Mercury; Porphobilinogen synthase; Pregnant rats; Renal function

Indexed keywords

CREATININE; DRINKING WATER; MERCURY; PORPHOBILINOGEN SYNTHASE; UREA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOCHEMICAL COMPOSITION; BLOOD PLACENTA BARRIER; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CREATININE BLOOD LEVEL; ENVIRONMENTAL EXPOSURE; ENZYME ACTIVITY; FEMALE; FLUID INTAKE; KIDNEY INJURY; KIDNEY MASS; MALE; MERCURIALISM; NONHUMAN; PROGENY; RAT; TOXICOKINETICS; TOXIN ANALYSIS; UREA BLOOD LEVEL; WATER ANALYSIS; WEIGHT GAIN;

ANIMALS; FEEDING BEHAVIOR; FEMALE; MATERNAL EXPOSURE; MERCURY; PREGNANCY; RATS; RATS, WISTAR; WATER SUPPLY; WEIGHT GAIN;

RATTUS; RATTUS NORVEGICUS;

EID: 84861430643     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2012.04.046     Document Type: Article

References (56)

1. Agarwal R., Goel S.K., Chandra R., Behari J.R. Role of vitamin E in preventing acute mercury toxicity in rat. Environ. Toxicol. Pharmacol. 2010, 29:70-78.
2. Al-Saleh I., Shinwari N., Mashhour A., Mohamed G.E.D., Rabah A. Heavy metals (lead, cadmium and mercury) in maternal, cord blood and placenta of healthy women. Int. J. Hyg. Environ. Health 2011, 214:79-101.
3. Ask K., Akesson A., Berglund M., Vahter M. Inorganic mercury and methylmercury in placentas of Swedish women. Environ. Health Perspect. 2002, 110:523-526.
4. Atkinson A., Thompson S.J., Khan A.T., Graham T.C., Ali S., Shannon C., Clarke O., Upchurch L. Assessment of a two-generation reproductive and fertility study of mercuric chloride in rats. Food Chem. Toxicol. 2001, 39:73-84.
5. Bernard A., Lauwerys R. Metal-induced alterations of δ-aminolevulinic acid dehydratase. Ann. NY Acad. Sci. 1987, 514:41-47.
6. Bradford M.M. A rapid and sensitive method for quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976, 72:248-254.
7. Brandão R., Santos F.W., Farina M., Zeni G., Bohrer D., Rocha J.B.T., Nogueira C.W. Antioxidants and metallothionein levels in mercury-treated mice. Cell Biol. Toxicol. 2006, 22:429-438.
8. Budtz-Jørgensen E., Grandjean P., Jørgensen P.J., Weihe P., Keiding N. Association between mercury concentrations in blood and hair in methylmercury-exposed subjects at different ages. Environ. Res. 2004, 95:385-393.
9. Clarkson T.W. Mercury: major issues in environmental health. Environ. Health Perspect. 1992, 100:31-38.
10. Corpas I., Castillo M., Marquina D., Benito M.J. Lead intoxication in gestational and lactation periods alters the development of male reproductive organs. Ecotoxicol. Environ. Saf. 2002, 53:259-266.
11. Counter S.A., Buchanan L.H. Mercury exposure in children: a review. Toxicol. Appl. Pharmacol. 2004, 198:209-230.
12. Dabrio M., Rodríguez A.R., Bordin G., Bebianno M.J., De Ley M., Sestáková I., Vasák M., Nordberg M. Recent developments in quantification methods for metallothionein. J. Inorg. Biochem. 2002, 88:123-134.
13. De Rosis F., Anastasio S.P., Selvaggi L., Beltrame A., Moriani G. Female reproductive health in two lamp factories: effects of exposure to inorganic mercury vapour and stress factors. Br. J. Ind. Med. 1985, 42:488-494.
14. Debes F., Budtz-Jørgensen E., Weihe P., White R.F., Grandjean P. Impact of prenatal methylmercury exposure on neurobehavioral function at age 14years. Neurotoxicol. Teratol. 2006, 28:363-375.
15. Ekino S., Susa M., Ninomiya T., Imamura K., Kitamura T. Minamata disease revisited: an update on the acute and chronic manifestations of methyl mercury poisoning. J. Neurol. Sci. 2007, 262:131-144.
16. Ekstrand J., Nielsen J.B., Havarinasab S., Zalups R.K., Söderkvist P., Hultman P. Mercury toxicokinetics-dependency on strain and gender. Toxicol. Appl. Pharmacol. 2010, 243:283-291.
17. Emanuelli T., Rocha J.B.T., Pereira M.E., Porciúncula L.O., Morsch V.M., Martins A.F., Souza D.O. Effect of mercuric chloride intoxication and dimercaprol treatment on α-aminolevulinate dehydratase from brain, liver and kidney of adult mice. Pharmacol. Toxicol. 1996, 79:139-143.
18. Farina M., Brandão R., Lara F.S., Pagliosa L.B., Soares F.A., Souza D.O., Rocha J.B.T. Profile of nonprotein thiols, lipid peroxidation and δ-aminolevulinate dehydratase activity in mouse kidney and liver in response to acute exposure to mercuric chloride and sodium selenite. Toxicology 2003, 184:179-187.
19. Farmanfarmaian A., Pugliese K.A., Sun L.-Z. Mercury inhibits the transport of d-glucose by the intestinal brush border membrane vesicles of fish. Mar. Environ. Res. 1989, 28:247-251.
20. Feng W., Wang M., Li B., Liu J., Chai Z., Zhao J., Deng G. Mercury and trace element distribution in organic tissues and regional brain of fetal rat after in utero and weaning exposure to low dose of inorganic mercury. Toxicol. Lett. 2004, 152:223-234.
21. Filipak Neto F., Zanata S.M., Silva de Assis H.C., Nakao L.S., Randi M.A.F., Oliveira Ribeiro C.A. Toxic effects of DDT and methyl mercury on the hepatocytes from Hoplias malabaricus. Toxicol. in Vitro 2008, 22:1705-1713.
22. 2. Int. J. Dev. Neurosci. 2009, 27:459-468.
23. Franciscato C., Moraes-Silva L., Duarte F.A., Oliveira C.S., Ineu R.P., Flores E.M.M., Dressler V.L., Peixoto N.C., Pereira M.E. Delayed biochemical changes induced by mercury intoxication are prevented by zinc pre-exposure. Ecotoxicol. Environ. Saf. 2011, 74:480-486.
24. Graeme K.A., Pollack C.V. Heavy metal toxicity, part I: arsenic and mercury. J. Emerg. Med. 1998, 16:45-56.
25. Holt D., Webb M. The toxicity and teratogenicity of mercury in the pregnant rat. Arch. Toxicol. 1986, 58:243-248.
26. Klaassen C.D., Liu J., Choudhuri S. Metallothionein: an intracellular protein to protect against cadmium toxicity. Annu. Rev. Pharmacol. Toxicol. 1999, 39:267-294.
27. Kuriwaki J., Nishijo M., Honda R., Tawara K., Nakagawa H., Hori E., Nishijo H. Effects of cadmium exposure during pregnancy on trace elements in fetal rat liver and kidney. Toxicol. Lett. 2005, 156:369-376.
28. Lorschieder F.L., Vimy M.J., Summers A.O. Mercury exposure from " silver" tooth filling: emerging evidence questions a traditional dental paradigm. FASEB J. 1995, 9:504-508.
29. Madsen K.M., Maunsbach A.B. Effects of chronic mercury exposure on the rat kidney cortex as studied morphometrically by light and electron microscopy. Virchows Arch. 1981, 37:137-152.
30. Malagutti K.S., Silva A.P., Braga H.C., Mitozo P.A., Santos A.R.S., Dafre A.L., Bem A.F., Farina M. 17β-estradiol decreases methylmercury-induced neurotoxicity in male mice. Environ. Toxicol. Pharmacol. 2009, 27:293-297.
31. Nath R., Kumar D., Li T., Singal P.K. Metallothioneins, oxidative stress and the cardiovascular system. Toxicology 2000, 155:17-26.
32. Nevado J.J.B., Martín-Doimeadios R.C.R., Bernardo F.J.G., Moreno M.J., Herculano A.M., Nascimento J.L.M., Crespo-López M.E. Mercury in the Tapajós River basin, Brazilian Amazon: a review. Environ. Int. 2010, 36:593-608.
33. Omotayo T.I., Rocha J.B.T., Ibukun E.O., Kade I.J. Inorganic mercury interacts with thiols at the nucleotide and cationic binding sites of the ouabain-sensitive cerebral electrogenic sodium pump. Neurochem. Int. 2011, 58:776-784.
34. Orisakwe O.E., Afonne O.J., Nwbodo E., Asomugha L., Dioka C.E. Low-dose mercury induces testicular damage protected by zinc in mice. Eur. J. Obstet. Gynecol. Reprod. Biol. 2001, 95:92-96.
35. Ornaghi F., Ferrini S., Prati M., Giavani E. The protective effects of N-acetil-l-cysteine against methyl mercury embryotocixity in mice. Fund. Appl. Toxicol. 1993, 20:437-445.
36. Pal M., Ghosh M. Studies on comparative efficacy of α-linolenic acid and α-eleostearic acid on prevention of organic mercury-induced oxidative stress in kidney and liver of rat. Food Chem. Toxicol. 2012, 50:1066-1072.
37. Palheta D., Taylor A. Mercury in environmental and biological samples from a gold mining area in the Amazon region of Brazil. Sci. Total Environ. 1995, 168:63-69.
38. 2 on porphobilinogen-synthase (E. C. 4. 2. 1. 24) activity and on mercury levels in rats exposed during different precocious periods of postnatal life. Cell Biol. Int. 2007, 31:1057-1062.
39. 2 in newborn rats. Ecotoxicol. Environ. Saf. 2007, 66:441-446.
40. 2-δ-ALA-D inhibition and Hg levels in tissues of suckling rats. Toxicol. Lett. 2003, 146:17-25.
41. 2 depend on the postnatal period of exposure. Int. J. Dev. Neurosci. 2007, 25:39-46.
42. Peixoto N.C., Roza T., Pereira M.E. Sensitivity of δ-ALA-D (E.C.4.2.1.24) of rats to metals in vitro depends on the stage of postnatal growth and tissue. Toxicol. in Vitro 2004, 18:805-809.
43. Risher J.F., Nickle R.A., Amler S.N. Elemental mercury poisoning in occupational and residential settings. Int. J. Hyg. Environ. Health 2003, 206:371-379.
44. Rocha J.B.T., Pereira M.E., Emanuelli T., Christofari S.R., Souza D.D. Effect of treatment with mercury chloride and lead acetate during the second stage of rapid postnatal brain growth on δ-aminolevulinic acid dehydratase (ALA-D) activity in brain, liver, kidney and blood of suckling rats. Toxicology 1995, 100:27-37.
45. 2. Basic Clin. Pharmacol. Toxicol. 2005, 96:302-308.
46. Salehi Z., Esmaili-Sari A. Hair mercury levels in pregnant women in Mahshahr, Iran: fish consumption as a determinant of exposure. Sci. Total Environ. 2010, 408:4848-4854.
47. Sassa S. Delta-aminolevulinic acid dehydratase assay. Enzyme 1982, 28:133-145.
48. Sastry K.V., Rao D.R., Singh S.K. Mercury induced alterations in the intestinal, absorption of nutrients in the fresh water murrel, Channa punctatus. Chemosphere 1982, 11:613-619.
49. Shuurs A.H.B. Reproductive toxicity of occupational mercury. a review of the literature. J. Dent. 1999, 27:249-256.
50. Stringari J., Nunes A.K.C., Franco J.L., Bohrer D., Garcia S.C., Dafre A.L., Milatovic D., Souza D.O., Rocha J.B.T., Aschner M., Farina M. Prenatal methylmercury exposure hampers glutathione antioxidant system ontogenesis and causes long-lasting oxidative stress in the mouse brain. Toxicol. Appl. Pharmacol. 2008, 227:147-154.
51. Vicente E., Boer M., Netto C., Fochesatto C., Dalmaz C., Siqueira I.R., Gonçalves C.-A. Hippocampal antioxidant system in neonates from methylmercury-intoxicated rats. Neurotoxicol. Teratol. 2004, 26:817-823.
52. Walker J.B., Houseman J., Seddon L., McMullen E., Tofflemire K., Mills C., Corriveau A., Weber J.-P., LeBlanc A., Walker M., Donaldson S.G., Oostdam J.V. Maternal and umbilical cord blood levels of mercury, lead, cadmium, and essential trace elements in Artic Canada. Environ. Res. 2006, 100:295-318.
53. Weihe P., Grandjean P., Jørgensen P.J. Application of hair-mercury analysis to determine the impact of a seafood advisory. Environ. Res. 2005, 97:201-208.
54. WHO Inorganic Mercury, Environmental Health Criteria 118 2003, World Health Organization, Geneva.
55. Yoshida M., Satoh M., Shimada A., Yamamoto E., Yasutake A., Tohyama C. Maternal-to-fetus transfer of mercury in metallothionein-null pregnant mice after to mercury vapor. Toxicology 2002, 175:215-222.
56. Zahir F., Rizwi S.J., Haq S.K., Khan R.H. Low dose mercury toxicity and human health. Environ. Toxicol. Pharmacol. 2005, 20:351-360.