Ethical issues in brain-computer interface research, development, and dissemination

Journal of Neurologic Physical Therapy

Volumn 36, Issue 2, 2012, Pages 94-99

  Vlek, Rutger J ^a   Steines, David ^b   Szibbo, Dyana ^c   Kübler, Andrea ^d   Schneider, Mary Jane ^e,f   Haselager, Pim ^a   Nijboer, Femke ^g  

^a RADBOUD UNIVERSITY   (Netherlands)

^b University of Illinois at Urbana Champaign   (United States)

^c NeuroSky Brain Computer Interface Technologies   (United States)

^d UNIVERSITY OF WÜRZBURG   (Germany)

^e WADSWORTH CENTER   (United States)

^f STATE UNIVERSITY OF NEW YORK   (United States)

^g UNIVERSITY OF TWENTE   (Netherlands)

Author keywords

brain computer interface; ethics; locked in syndrome; neuroethics

Indexed keywords

BRAIN DISEASE; CASE REPORT; COMMUNICATION AID; COMPUTER INTERFACE; EDUCATION; ETHICS; HUMAN; INSTRUMENTATION; MEDICAL RESEARCH; METHODOLOGY; REVIEW;

BIOMEDICAL RESEARCH; BRAIN DISEASES; COMMUNICATION AIDS FOR DISABLED; EDUCATION; HUMANS; USER-COMPUTER INTERFACE;

EID: 84861419397     PISSN: 15570576     EISSN: 15570584     Source Type: Journal    
DOI: 10.1097/NPT.0b013e31825064cc     Document Type: Review

References (55)

1. Dornhege G, del R, Millán J, Hinterberger T, McFarland D, Müller KR, eds. Toward Brain-Computer Interfacing. Cambridge, MA: MIT Press; 2007.
2. Van GervenM, Farquhar J, Schaefer R, et al. The brain-computer interface cycle. J Neural Eng. 2009; 6 (4): 041001.
3. Daly J, Wolpaw J. Brain-computer interfaces in neurological rehabilitation. Lancet Neural. 2008; 7: 1032-1043.
4. Wessberg J, Stambaugh C, Kralik J, et al. Real-time prediction of hand trajectory by ensembles of cortical neurons in primates. Nature. 2000; 408: 361-365.
5. Carmena J, Lebedev M, Crist R, et al. Learning to control a brain-machine interface for reaching and grasping by primates. PLoS Biol. 2003; 1 (2): 0000042.
6. Serruya M, Hatsopoulos N, Paninski L, Fellows M, Donoghue J. Brainmachine interface: Instant neural control of a movement signal. Nature. 2002; 416: 141-142. (Pubitemid 34246464)
7. Kim S, Simeral J, Hochberg L, Donoghue J. Neural control of computer cursor velocity by decoding motor cortical spiking activity in humans with tetraplegia. J Neural Eng. 2008; 5 (4): 455-476.
8. Sellers E, Donchin E. A P300-based brain-computer interface: initial tests by ALS patients. Clin Neurophysiol. 2006; 117: 538-548. (Pubitemid 43343986)
9. Nijboer F, Sellers E, Mellinger J, et al. A brain-computer interface (BCI) for people with amyotrophic lateral sclerosis (ALS). Clin Neurophysiol. 2008; 119 (8): 1909-1916.
10. Schreuder M, Blankertz B, Tangermann M. A new auditory multi-class brain-computer interface paradigm: spatial hearing as an informative cue. PLoS One. 2010; 5 (4): e9813.
11. Zickler C, Riccio A, Leotta F, et al. A brain-computer interface as input channel for a standard assistive technology software. Clin EEG Neurosci. 2011; 42 (4): 222-230.
12. Ahi S, Kambara H, Koike Y. A dictionary-driven p300 speller with a modified interface. IEEE Trans Neural Syst Rehabil Eng. 2011; 19 (1): 6-14.
13. Geuze J, Desain P, Ringelberg J. Re-phrase: chat-by-click: a fundamental new mode of human communication over the Internet. In: CHI '08 extended abstracts on Human factors in computing systems. CHI EA '08; New York, NY: ACM; 2008: 3345-3350.
14. Vanacker G, del R, Millán J, et al. Context-based filtering for assisted brain-actuated wheelchair driving. Comput Intel Neurosci. 2007; 25130.
15. McFarland D, Sarnacki W, Wolpaw J. Electroencephalographic (EEG) control of three-dimensional movement. J Neural Eng. 2011; 7 (3): 036007.
16. Buch E, Weber C, Cohen L, et al. Think to move: a neuromagnetic braincomputer interface (BCI) system for chronic stroke. Stroke. 2008; 39: 910-917. (Pubitemid 351619582)
17. Daly J, Cheng R, Rogers J, Litinas K, Hrovat K, DohringM. Feasibility of a new application of noninvasive brain computer interface (BCI): a case study of training for recovery of volitional motor control after stroke. J Neurol Phys Ther. 2009; 33 (4): 203-211.
18. Rodriguez MG, Grosse-Wentrup M, Hill J, Gharabaghi A, Schölkopf B, Peters J. Towards brain-robot interfaces in stroke rehabilitation. In: Proceedings of 12th International Conference on Rehabilitation Robotics. 2011: 1-6.
19. DeCharms R, Maeda F, Glover G, et al. Control over brain activation and pain learned by using real-time functional MRI. Proc Natl Acad Sci U S A.2005; 102: 18626-18631. (Pubitemid 43011276)
20. Weiskopf N. Real-time fMRI and its application to neurofeedback [published online ahead of print October 14, 2011]. Neuroimage. In press. doi: 10.1016/j.neuroimage.2011.10.009.
21. Zotev V, Krueger F, Phillips R, et al. Self-regulation of amygdala activation using real-time fMRI neurofeedback. PLoS One. 2011; 6 (9): e24522.
22. Nijholt A, Bos DPO, Reuderink B. Turning shortcomings into challenges: brain-computer interfaces for games. Entertain Comput. 2009; 1 (2): 85-94.
23. Münssinger JI, Halder S, Kleih S, et al. Brain painting: evaluation of a new brain-computer interface application with ALS patients and healthy volunteers. Front Neurosci. 2010; 4 (182).
24. Clausen J. Man, machine and in between. Nature. 2009; 457: 1080-1081.
25. Haselager P, Vlek R, Hill J, Nijboer F. A note on ethical aspects of BCI. Neural Netw. 2009; 22 (9): 1352-1357.
26. Tamburrini G. Brain to computer communication: ethical perspectives on interaction models. Neuroethics. 2009; 2: 137-149.
27. Tamburrini G, Mattia D. Disorders of consciousness and communication: ethical motivations and communication-enabling attributes of consciousness. Funct Neurol. 2011; 26 (1): 51-54.
28. Fenton A, Alpert S. Extending our view on using BCIs for locked-in syndrome. Neuroethics. 2008; 1 (2): 119-132.
29. Walter S. Locked-in syndrome, BCI, and confusion about embodied, embedded, extended and enacted cognition. Neuroethics. 2010; 3: 61-72.
30. Farah M. Emerging ethical issues in neuroscience. Nat Neurosci. 2002; 5: 1123-1129. (Pubitemid 35247170)
31. Nadelhoffer T. The law and neuroscience blog. http: //lawneuro.typepad. com/the-law-and-neuroscience-blog/2010/06/call-for-.html. Published July 16, 2010.
32. Kübler A, Winter S, Ludolph A, Hautzinger M, Birbaumer N. Severity of depressive symptoms and quality of life in patients with amyotrophic lateral sclerosis. Neurorehabil Neural Repair. 2005; 19 (3): 182-193. (Pubitemid 41216294)
33. Beauchamp T,Childress J. Principles of Biomedical Ethics. 6th ed. Oxford New York: University Press; 2008: 129.
34. Richman D. Public access to experimental drug therapy: AIDS raises yet another conflict between freedom of the individual and welfare of the individual and public. J Infect Dis. 1989; 159: 412-415. (Pubitemid 19065885)
35. Leonard E. Right to experimental treatment: FDA new drug approval, constitutional rights, and the public's health. J Law Med Ethics. 2009; 37: 269-279.
36. World Medical Association. Declaration of Helsinki: Ethical principles for medical research involving human subjects (6th revision). http: //www.wma.net/en/30publications/10policies/b3/17c.pdf. Published June 23, 2010.
37. Kübler A, Birbaumer N. Brain-computer interfaces and communication in paralysis: extinction of goal directed thinking in completely paralysed patients? Clin Neurophysiol. 2008; 19 (11): 2658-2666.
38. Borasio G, Sloan R, Pongratz D. Breaking the news in amyotrophic lateral sclerosis. J Neurol Sci. 1998; 160 (1): S127-S133. (Pubitemid 28522531)
39. Nijboer F, Clausen J, Allison B, Haselager P. The Asilomar survey: stakeholders' opinions on ethical issues related to brain-computer interfacing [published online ahead of print October 20, 2011]. Neuroethics. DOI: 10.1007/s12152-011-9132-6.
40. Nijboer F, Kleih S, Kübler A. Das technisierte Gehirn; chap. Gehirn-Computer Schnittstellen Fuer Schwerstgelaehmte Menschen - klinische Moeglichkeiten, Technische Grenzen Und Etische Fragen. Paderborn: Mentis Verlag GmbH; 2009: 51-64.
41. Nijboer F, Birbaumer N, Kübler A. The influence of psychological state and motivation on brain-computer interface performance in patients with amyotrophic lateral sclerosis-a longitudinal study. Front Neuroprosthet. 2010; 4: 55.
42. Rozelle G, Budzynski T. Neurotherapy for stroke rehabilitation: a single case study. Biofeedback Self Regul. 1995; 20 (3): 211-228.
43. Pfurtscheller G, Neuper C. Future prospects of ERD/ERS in the context of brain-computer interface (BCI) developments. Prog Brain Res. 2006; 159: 433-437. (Pubitemid 44634659)
44. Prasad G, Herman P, Coyle D, McDonough S, Crosbie J. Using a motor imagery based brain-computer interface for post-stroke rehabilitation. In: Proceedings of 4th international IEEE/EMB conference on Neural Engineering. 2009: 258-262.
45. Slyter H. Ethical challenges in stroke research. Stroke. 1998; 29: 1725-1729. (Pubitemid 28365599)
46. Rain S, Williams V, Robbins P, Monahan J, Steadman H, Vesselinov R. Perceived coercion at hospital admission and adherence to mental health treatment after discharge. Psychiatr Serv. 2003; 54 (1): 103-105. (Pubitemid 36043855)
47. Hoedlmoser K, Pecherstorfer T,GruberG, et al. Instrumental conditioning of human sensorimotor rhythm (12-15 Hz) and its impact on sleep as well as declarative learning. Sleep. 2008; 31 (10): 1401-1408.
48. Nijboer F, Furdea A, Gunst I, et al. An auditory brain-computer interface (BCI). J Neurosci Methods. 2008; 167: 43-50. (Pubitemid 350186060)
49. McFarland D, Miner L, Vaughan T, Wolpaw J. Mu and beta rhythm topographies during motor imagery and actual movements. Brain Topogr. 2000; 12: 177-186. (Pubitemid 30232659)
50. Hildt E. Brain-computer interaction and medical access to the brain: individual, social and ethical implications. Stud Ethics Law Technol. 2010; 4 (3): 1-20. doi: 10.2202/1941-6008.1143.
51. Klaming L, Haselager P. Did my brain implant make me do it? Questions raised by DBS regarding psychological continuity, responsibility for action and mental competence. Neuroethics. September 16th, 2010. DOI 10.1007/s12152-010- 9093-1.
52. Clausen J. Conceptual and ethical issues with brain-hardware interfaces. Curr Opin Psychiatry. 2011; 24 (6): 495-501.
53. Farah M. Neuroethics: the practical and the philosophical. Trends Cogn Sci. 2005; 9 (1): 34-40. (Pubitemid 40091931)
54. Caplan A, Elliott C. Is it ethical to use enhancement technologies to make us better than well? PLoS Med. 2004; 1 (3).
55. Forlini C, Racine E. Autonomy and coercion in academic "cognitive enhancement" using methylphenidate: perspectives of key stakeholders. Neuroethics. 2009; 2: 163-177.